Results 201 to 210 of about 32,587 (229)
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A DEAD-box RNA helicase in the Escherichia coli RNA degradosome
Nature, 1996The Escherichia coli RNA degradosome is a multi-enzyme complex that contains the exoribonuclease polynucleotide phosphorylase (PNPase) and the endoribonuclease RNase E. Both enzymes are important in RNA processing and messenger RNA degradation. Here we report that enolase and RhlB are two other major components of the degradosome.
B, Py +3 more
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DEAD-Box RNA helicases in animal gametogenesis
Molecular Biology, 2014This review analyzes and summarizes a current knowledge about a role of RNA helicases in the development and maintenance of gametogenesis of eukaryotic organisms. Here we focused on three representatives of RNA helicase family containing the characteristic motifs in the amino acid sequence (DEAD-box) and carrying substantial and conservative functions ...
A A, Kotov +3 more
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The DEAD-box protein family of RNA helicases
Gene, 2006RNA helicases of the DEAD-box protein family have been shown to participate in every aspect of RNA metabolism. They are present in most organisms where they work as RNA helicases or RNPases. The properties of these enzymes in vivo remains poorly described, however some were extensively characterized in vitro, and the solved crystal structures of a few ...
Cordin, Olivier +3 more
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DEAD-Box RNA Helicases as Transcription Cofactors
2012It is established that several DEAD box RNA helicases perform multiple functions in the cell, often through interactions with different partner proteins in a context-dependent manner. Several studies have shown that some DEAD box proteins play important roles as regulators of transcription, particularly as coactivators or cosuppressors of transcription
Fuller-Pace, Frances V. +1 more
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Hydrodynamic Characterization of the DEAD-box RNA Helicase DbpA
Journal of Molecular Biology, 2006The Escherichia coli DEAD-box protein A (DbpA) belongs to the highly conserved superfamily-II of nucleic acid helicases that play key roles in RNA metabolism. A central question regarding helicase activity is whether the process of coupling ATP hydrolysis to nucleic acid unwinding requires an oligomeric form of the enzyme.
Miguel A, Talavera +6 more
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Signaling to the DEAD box—Regulation of DEAD-box p68 RNA helicase by protein phosphorylations
Cellular Signalling, 2005P68 nuclear RNA helicase is essential for normal cell growth. The protein plays a very important role in cell development and proliferation. However, the molecular mechanism by which the p68 functions in cell developmental program is not clear. We previously observed that bacterially expressed his-p68 was phosphorylated at multiple sites including ...
Liuqing, Yang, Chunru, Lin, Zhi-Ren, Liu
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Looking back on the birth of DEAD-box RNA helicases
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013DEAD-box proteins represent the largest family of RNA helicases, present in all three kingdoms of life. They are involved in a variety of processes involving RNA metabolism and in some instances also in processes that use guide RNAs. Since their first descriptions in the late 1980s, the perception of their molecular activities has dramatically changed.
Linder, Patrick, Fuller-Pace, Frances
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The DEAD-Box RNA Helicase Dbp5 Functions in Translation Termination
Science, 2007In eukaryotes, termination of messenger RNA (mRNA) translation is mediated by the release factors eRF1 and eRF3. Using Saccharomyces cerevisiae as a model organism, we have identified a member of the DEAD-box protein (DBP) family, the DEAD-box RNA helicase and mRNA export factor Dbp5, as a ...
Thomas, Gross +7 more
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DEAD-Box Helicases Form Nucleotide-Dependent, Long-Lived Complexes with RNA
Biochemistry, 2014DEAD-box RNA helicases bind and remodel RNA and RNA-protein complexes in an ATP-dependent fashion. Several lines of evidence suggest that DEAD-box RNA helicases can also form stable, persistent complexes with RNA in a process referred to as RNA clamping. The molecular basis of RNA clamping is not well understood.
Fei, Liu +2 more
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A Novel Human Homolog of a Dead-Box RNA Helicase Family
Biochemical and Biophysical Research Communications, 1994Putative cDNA clones for a nuclear antigen that cross-reacts with anti-human aldolase A monoclonal antibody MAb1A2 were isolated from the HeLa lambda gt11 cDNA library and a candidate clone (clone 3) was analyzed. The cDNA has an open reading frame (ORF) of 1,317 bp encoding a novel RNA helicase belonging to the DEAD RNA helicase family.
Y, Kitajima +4 more
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