Selective pharmacological targeting of a DEAD box RNA helicase. [PDF]
PLoS ONE, 2008 RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected
Lisa Lindqvist +11 more
doaj +7 more sources
DEAD-Box Helicase 17 Promotes Amyloidogenesis by Regulating BACE1 Translation [PDF]
Brain Sciences, 2023 Amyloidogenesis is one of the key pathophysiological changes in Alzheimer’s disease (AD). Accumulation of the toxic Aβ results from the catalytic processing of β-amyloid precursor protein (APP) associated β-amyloid converting enzyme 1 (BACE1) activity ...
Yue Liu +10 more
doaj +4 more sources
DEAD-box helicase proteins disrupt RNA tertiary structure through helix capture. [PDF]
PLoS Biology, 2014 DEAD-box helicase proteins accelerate folding and rearrangements of highly structured RNAs and RNA-protein complexes (RNPs) in many essential cellular processes. Although DEAD-box proteins have been shown to use ATP to unwind short RNA helices, it is not
Cynthia Pan +6 more
doaj +6 more sources
DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Previous studies have shown that DEAD (Asp-Glu-Ala-Asp)-box RNA helicases play important roles in viral infection, either as cytosolic sensors of pathogenic molecules or as essential host factors against viral infection.
Rui Zhang +9 more
doaj +2 more sources
A DEAD-box helicase drives the partitioning of a pro-differentiation NAB protein into nuclear foci [PDF]
Nature Communications, 2023 How cells regulate gene expression in a precise spatiotemporal manner during organismal development is a fundamental question in biology. Although the role of transcriptional condensates in gene regulation has been established, little is known about the ...
Akiko Doi +3 more
doaj +2 more sources
DEAD-box helicase family proteins: emerging targets in digestive system cancers and advances in targeted drug development [PDF]
Journal of Translational MedicineCancer has become one of the major diseases threatening human health in the twenty-first century due to its incurability. In 2022, new cases of esophageal and gastrointestinal cancers accounted for 17.1% of all newly diagnosed cancer cases worldwide ...
Xiaochao Ma +6 more
doaj +2 more sources
High-resolution fleezers reveal duplex opening and stepwise assembly by an oligomer of the DEAD-box helicase Ded1p [PDF]
Nature CommunicationsDEAD-box RNA-dependent ATPases are ubiquitous in all domains of life where they bind and remodel RNA and RNA-protein complexes. DEAD-box ATPases with helicase activity unwind RNA duplexes by local opening of helical regions without directional movement ...
Eric M. Patrick +6 more
doaj +2 more sources
The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X [PDF]
Nature Communications, 2019 DEAD-box helicases (DDXs) function in an ATP-dependent, non-processive manner and the conserved helicase core is composed of two RecA-like domains D1 and D2.
He Song, Xinhua Ji
doaj +2 more sources
DEAD-box Helicase 27 Promotes Hepatocellular Carcinoma Progression Through ERK Signaling [PDF]
Technology in Cancer Research & Treatment, 2021 Introduction: DEAD-box helicase 27 (DDX27) belongs to DEAD-Box nucleic acid helicase family. The function of DDX27 in hepatocellular carcinoma (HCC) remain enigmatic.
Wang Xiaoqian +10 more
doaj +2 more sources
DDX5 facilitates HIV-1 replication as a cellular co-factor of Rev. [PDF]
PLoS ONE, 2013 HIV-1 Rev plays an important role in the late phase of HIV-1 replication, which facilitates export of unspliced viral mRNAs from the nucleus to cytoplasm in infected cells. Recent studies have shown that DDX1 and DDX3 are co-factors of Rev for the export
Xiuxia Zhou +9 more
doaj +6 more sources