Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer [PDF]
Frontiers in Oncology, 2023 Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately, this disease is changing rapidly to a younger age, and in a more advanced stage
Bichun Zheng +4 more
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DEAD-Box Helicase 17 Promotes Amyloidogenesis by Regulating BACE1 Translation [PDF]
Brain Sciences, 2023 Amyloidogenesis is one of the key pathophysiological changes in Alzheimer’s disease (AD). Accumulation of the toxic Aβ results from the catalytic processing of β-amyloid precursor protein (APP) associated β-amyloid converting enzyme 1 (BACE1) activity ...
Yue Liu +10 more
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DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Previous studies have shown that DEAD (Asp-Glu-Ala-Asp)-box RNA helicases play important roles in viral infection, either as cytosolic sensors of pathogenic molecules or as essential host factors against viral infection.
Rui Zhang +9 more
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A DEAD-box helicase drives the partitioning of a pro-differentiation NAB protein into nuclear foci [PDF]
Nature Communications, 2023 How cells regulate gene expression in a precise spatiotemporal manner during organismal development is a fundamental question in biology. Although the role of transcriptional condensates in gene regulation has been established, little is known about the ...
Akiko Doi +3 more
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DEAD-box helicase family proteins: emerging targets in digestive system cancers and advances in targeted drug development [PDF]
Journal of Translational MedicineCancer has become one of the major diseases threatening human health in the twenty-first century due to its incurability. In 2022, new cases of esophageal and gastrointestinal cancers accounted for 17.1% of all newly diagnosed cancer cases worldwide ...
Xiaochao Ma +6 more
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High-resolution fleezers reveal duplex opening and stepwise assembly by an oligomer of the DEAD-box helicase Ded1p [PDF]
Nature CommunicationsDEAD-box RNA-dependent ATPases are ubiquitous in all domains of life where they bind and remodel RNA and RNA-protein complexes. DEAD-box ATPases with helicase activity unwind RNA duplexes by local opening of helical regions without directional movement ...
Eric M. Patrick +6 more
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DEAD-box Helicase 27 Promotes Hepatocellular Carcinoma Progression Through ERK Signaling [PDF]
Technology in Cancer Research & Treatment, 2021 Introduction: DEAD-box helicase 27 (DDX27) belongs to DEAD-Box nucleic acid helicase family. The function of DDX27 in hepatocellular carcinoma (HCC) remain enigmatic.
Wang Xiaoqian +10 more
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The emerging role of DEAD/H-box helicases in hepatitis B virus infection
Frontiers in Cellular and Infection Microbiology, 2022 DEAD/H-box helicases are an essential protein family with a conserved motif containing unique amino acid sequences (Asp-Glu-Ala-Asp/His). Current evidence indicates that DEAD/H-box helicases regulate RNA metabolism and innate immune responses.
Hongjuan You +11 more
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Journal of Plant Interactions, 2022 The DEAD-box family has been shown to play an important role in a variety of abiotic stresses, but little is known in studies of mangrove plants. Here, the effects of cold stress on various physiological changes and the role of the DEAD-box RNA helicase ...
LuLu Hao +6 more
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The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity
iScience, 2020 Summary: Members of the DEAD-box helicase family are involved in all fundamental processes of RNA metabolism, and as such, their malfunction is associated with various diseases.
Maria J. Marcaida +8 more
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