Results 1 to 10 of about 20,358 (251)

DEAD-box helicase proteins disrupt RNA tertiary structure through helix capture. [PDF]

PLoS Biology, 2014
DEAD-box helicase proteins accelerate folding and rearrangements of highly structured RNAs and RNA-protein complexes (RNPs) in many essential cellular processes. Although DEAD-box proteins have been shown to use ATP to unwind short RNA helices, it is not
Cynthia Pan, Jeffrey P Potratz, Brian Cannon, Zachary B Simpson, Jessica L Ziehr, Pilar Tijerina, Rick Russell   +6 more
doaj   +2 more sources

DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense [PDF]

Viruses, 2020
DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family have roles throughout cellular RNA metabolism from biogenesis to decay ...
Frances Taschuk, Sara Cherry
doaj   +3 more sources

Comprehensive comparative analysis and expression profiles and effects on physiological response of DEAD-box RNA helicase genes in Lumnitzera littorea (Jack) Voigt under cold stress

Journal of Plant Interactions, 2022
The DEAD-box family has been shown to play an important role in a variety of abiotic stresses, but little is known in studies of mangrove plants. Here, the effects of cold stress on various physiological changes and the role of the DEAD-box RNA helicase ...
LuLu Hao, Ying Zhang, Yin Li, Linxia Bai, Danfei Yue, Huiyu Zhang, Chunfang Zheng   +6 more
doaj   +1 more source

The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity

iScience, 2020
Summary: Members of the DEAD-box helicase family are involved in all fundamental processes of RNA metabolism, and as such, their malfunction is associated with various diseases.
Maria J. Marcaida, Annamaria Kauzlaric, Alice Duperrex, Jenny Sülzle, Martin C. Moncrieffe, Damilola Adebajo, Suliana Manley, Didier Trono, Matteo Dal Peraro   +8 more
doaj   +1 more source

DDX19A Promotes Metastasis of Cervical Squamous Cell Carcinoma by Inducing NOX1-Mediated ROS Production

Frontiers in Oncology, 2021
The major obstacle to treat cervical squamous cell carcinoma (CSCC) is the high prevalence of metastasis, which severely affects 5-year survival rate and quality of life for cancer patients. The DEAD-box helicase family has been reported to be a critical
Yanhui Jiang, Yanhui Jiang, Baibin Wang, Yongliang Li, Jiahui Shen, Yutao Wei, Hanjie Li, Hanjie Li, Shangqiu Chen, Hua Yang, Famin Zeng, Changqing Liu, Feng Wang, Huanhuan He, Yong Chen, Jihong Liu, Jihong Liu   +16 more
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Genome-Wide Analysis of DEAD-box RNA Helicase Family in Wheat (Triticum aestivum) and Functional Identification of TaDEAD-box57 in Abiotic Stress Responses

Frontiers in Plant Science, 2021
DEAD-box RNA helicases constitute the largest subfamily of RNA helicase superfamily 2 (SF2), and play crucial roles in plant growth, development, and abiotic stress responses.
Jing-Na Ru, Jing-Na Ru, Ze-Hao Hou, Lei Zheng, Qi Zhao, Feng-Zhi Wang, Jun Chen, Yong-Bin Zhou, Ming Chen, You-Zhi Ma, Ya-Jun Xi, Zhao-Shi Xu   +11 more
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Genome-wide comparative in silico analysis of the RNA helicase gene family in Zea mays and Glycine max: a comparison with Arabidopsis and Oryza sativa. [PDF]

PLoS ONE, 2013
RNA helicases are enzymes that are thought to unwind double-stranded RNA molecules in an energy-dependent fashion through the hydrolysis of NTP. RNA helicases are associated with all processes involving RNA molecules, including nuclear transcription ...
Ruirui Xu, Shizhong Zhang, Jinguang Huang, Chengchao Zheng   +3 more
doaj   +1 more source

Role reversal of functional identity in host factors: Dissecting features affecting pro-viral versus antiviral functions of cellular DEAD-box helicases in tombusvirus replication.

PLoS Pathogens, 2020
Positive-stranded (+)RNA viruses greatly exploit host cells to support viral replication. However, unlike many other pathogens, (+)RNA viruses code for only a limited number of genes, making them highly dependent on numerous co-opted host factors for ...
Cheng-Yu Wu, Peter D Nagy
doaj   +1 more source

Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12

Brazilian Journal of Medical and Biological Research, 2001
DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension
A.A. Camargo, D.N. Nunes, H.B. Samaia, L. Liu, V.P. Collins, A.J.G. Simpson, E. Dias-Neto   +6 more
doaj   +1 more source

Allosteric activation of RhlB by RNase E induces partial duplex opening in substrate RNA

Frontiers in Molecular Biosciences, 2023
The E. coli DEAD-Box helicase RhlB is responsible for ATP-dependent unwinding of structured mRNA to facilitate RNA degradation by the protein complex degradosome.
Heidi Zetzsche, Laura Raschke, Boris Fürtig   +2 more
doaj   +1 more source