Results 11 to 20 of about 1,397,424 (256)
Selective pharmacological targeting of a DEAD box RNA helicase. [PDF]
PLoS ONE, 2008 RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected
Lisa Lindqvist +11 more
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DEAD box RNA helicase functions in cancer [PDF]
RNA Biology, 2013 Members of the DEAD box family of RNA helicases are known to be involved in most cellular processes that require manipulation of RNA structure and, in many cases, exhibit other functions in addition to their established ATP-dependent RNA helicase activities.
Fuller-Pace, Frances V.
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DEAD-box helicase proteins disrupt RNA tertiary structure through helix capture. [PDF]
PLoS Biology, 2014 DEAD-box helicase proteins accelerate folding and rearrangements of highly structured RNAs and RNA-protein complexes (RNPs) in many essential cellular processes. Although DEAD-box proteins have been shown to use ATP to unwind short RNA helices, it is not
Cynthia Pan +6 more
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PLoS Pathogens, 2019 Positive-stranded RNA viruses replicate inside cells and depend on many co-opted cellular factors to complete their infection cycles. To combat viruses, the hosts use conserved restriction factors, such as DEAD-box RNA helicases, which can function as ...
Cheng-Yu Wu, Peter D Nagy
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mBio, 2018 Present in every kingdom of life, generally in multiple copies, DEAD-box RNA helicases are specialized enzymes that unwind RNA secondary structures. They play major roles in mRNA decay, ribosome biogenesis, and adaptation to cold temperatures.
Lamya El Mortaji +7 more
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Investigations of the DEAD-box helicase eIF4A [PDF]
, 2011 Eukaryotic Initiation Factor (eIF) 4A is the most abundant initiation factor and the prototypical member of the DEAD-box family of helicases. Once recruited to the cap-binding complex, eIF4F, eIF4A unwinds inhibitory RNA secondary structure in the 5’ untranslated region (UTR) of mRNAs, promoting efficient ribosomal scanning to the start codon.
Phillips, Nicola Marie
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DEAD-Box RNA Helicases and Genome Stability [PDF]
Genes, 2021 DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome. Current studies have provided insight into the connection between genomic stability and several DEAD-box ...
Michael Cargill +2 more
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‘DEAD-box’ helicase from Plasmodium falciparum is active at wide pH and is schizont stage-specific [PDF]
Journal of Vector Borne Diseases, 2007 Background & objectives: DNA helicases catalyse unwinding of duplex DNA in an ATP-dependentmanner and are involved in all the basic genetic processes.
Arun Pradhan, +2 more
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AMP Sensing by DEAD-Box RNA Helicases [PDF]
Journal of Molecular Biology, 2013 In eukaryotes, cellular levels of adenosine monophosphate (AMP) signal the metabolic state of the cell. AMP concentrations increase significantly upon metabolic stress, such as glucose deprivation in yeast. Here, we show that several DEAD-box RNA helicases are sensitive to AMP, which is not produced during ATP hydrolysis by these enzymes.
Andrea A, Putnam, Eckhard, Jankowsky
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Wait and capture: unwinding the strategy of a DEAD-box helicase. [PDF]
PLoS Biology, 2014 RNA plays a wide variety of roles in every cell, from structural to informational to catalytic. That variety depends in large part on its ability to adopt a three-dimensional conformation suited to each application, often in tight association with protein or other polynucleotides.
Richard Robinson
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