Results 11 to 20 of about 20,358 (251)
Selective pharmacological targeting of a DEAD box RNA helicase. [PDF]
PLoS ONE, 2008 RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected
Lisa Lindqvist +11 more
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Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer [PDF]
Frontiers in Oncology, 2023 Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately, this disease is changing rapidly to a younger age, and in a more advanced stage
Bichun Zheng +4 more
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DEAD box RNA helicase functions in cancer [PDF]
RNA Biology, 2013 Members of the DEAD box family of RNA helicases are known to be involved in most cellular processes that require manipulation of RNA structure and, in many cases, exhibit other functions in addition to their established ATP-dependent RNA helicase ...
Fuller-Pace, Frances V.
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DEAD-Box Helicase 17 Promotes Amyloidogenesis by Regulating BACE1 Translation [PDF]
Brain Sciences, 2023 Amyloidogenesis is one of the key pathophysiological changes in Alzheimer’s disease (AD). Accumulation of the toxic Aβ results from the catalytic processing of β-amyloid precursor protein (APP) associated β-amyloid converting enzyme 1 (BACE1) activity ...
Yue Liu +10 more
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DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Previous studies have shown that DEAD (Asp-Glu-Ala-Asp)-box RNA helicases play important roles in viral infection, either as cytosolic sensors of pathogenic molecules or as essential host factors against viral infection.
Rui Zhang +9 more
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A DEAD-box helicase drives the partitioning of a pro-differentiation NAB protein into nuclear foci [PDF]
Nature Communications, 2023 How cells regulate gene expression in a precise spatiotemporal manner during organismal development is a fundamental question in biology. Although the role of transcriptional condensates in gene regulation has been established, little is known about the ...
Akiko Doi +3 more
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mBio, 2018 Present in every kingdom of life, generally in multiple copies, DEAD-box RNA helicases are specialized enzymes that unwind RNA secondary structures. They play major roles in mRNA decay, ribosome biogenesis, and adaptation to cold temperatures.
Lamya El Mortaji +7 more
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DEAD-box helicase family proteins: emerging targets in digestive system cancers and advances in targeted drug development [PDF]
Journal of Translational MedicineCancer has become one of the major diseases threatening human health in the twenty-first century due to its incurability. In 2022, new cases of esophageal and gastrointestinal cancers accounted for 17.1% of all newly diagnosed cancer cases worldwide ...
Xiaochao Ma +6 more
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PLoS Pathogens, 2019 Positive-stranded RNA viruses replicate inside cells and depend on many co-opted cellular factors to complete their infection cycles. To combat viruses, the hosts use conserved restriction factors, such as DEAD-box RNA helicases, which can function as ...
Cheng-Yu Wu, Peter D Nagy
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High-resolution fleezers reveal duplex opening and stepwise assembly by an oligomer of the DEAD-box helicase Ded1p [PDF]
Nature CommunicationsDEAD-box RNA-dependent ATPases are ubiquitous in all domains of life where they bind and remodel RNA and RNA-protein complexes. DEAD-box ATPases with helicase activity unwind RNA duplexes by local opening of helical regions without directional movement ...
Eric M. Patrick +6 more
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