Results 11 to 20 of about 34,246 (233)
The DEAD-box helicase eIF4A [PDF]
RNA Biology, 2013 DEAD-box helicases catalyze the ATP-dependent unwinding of RNA duplexes. They share a helicase core formed by two RecA-like domains that carries a set of conserved motifs contributing to ATP binding and hydrolysis, RNA binding and duplex unwinding. The translation initiation factor eIF4A is the founding member of the DEAD-box protein family, and one of
Alexandra Z, Andreou +1 more
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DEAD box RNA helicase functions in cancer [PDF]
RNA Biology, 2013 Members of the DEAD box family of RNA helicases are known to be involved in most cellular processes that require manipulation of RNA structure and, in many cases, exhibit other functions in addition to their established ATP-dependent RNA helicase activities.
Frances V Fuller-Pace
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Comparative structural analysis of human DEAD-box RNA helicases. [PDF]
PLoS ONE, 2010 DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections.
Patrick Schütz +12 more
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DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense [PDF]
Viruses, 2020 DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family have roles throughout cellular RNA metabolism from biogenesis to decay ...
Frances Taschuk, Sara Cherry
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From unwinding to clamping — the DEAD box RNA helicase family
Nature Reviews Molecular Cell Biology, 2011 RNA helicases of the DEAD box family are present in all eukaryotic cells and in many bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism from transcription to degradation and are therefore important players in gene expression.
Linder Patrick, Jankowsky Eckhard
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DEAD-Box RNA Helicases and Genome Stability [PDF]
Genes, 2021 DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome. Current studies have provided insight into the connection between genomic stability and several DEAD-box ...
Michael Cargill +2 more
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The emerging role of DEAD/H-box helicases in hepatitis B virus infection
Frontiers in Cellular and Infection Microbiology, 2022 DEAD/H-box helicases are an essential protein family with a conserved motif containing unique amino acid sequences (Asp-Glu-Ala-Asp/His). Current evidence indicates that DEAD/H-box helicases regulate RNA metabolism and innate immune responses.
Hongjuan You +11 more
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Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer
Frontiers in Oncology, 2023 Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately, this disease is changing rapidly to a younger age, and in a more advanced stage
Bichun Zheng +4 more
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Bacterial versatility requires DEAD-box RNA helicases [PDF]
FEMS Microbiology Reviews, 2015 RNA helicases of the DEAD-box and DEAH-box families are important players in many processes involving RNA molecules. These proteins can modify RNA secondary structures or intermolecular RNA interactions and modulate RNA-protein complexes. In bacteria, they are known to be involved in ribosome biogenesis, RNA turnover and translation initiation.
Redder P. +4 more
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AMP Sensing by DEAD-Box RNA Helicases [PDF]
Journal of Molecular Biology, 2013 In eukaryotes, cellular levels of adenosine monophosphate (AMP) signal the metabolic state of the cell. AMP concentrations increase significantly upon metabolic stress, such as glucose deprivation in yeast. Here, we show that several DEAD-box RNA helicases are sensitive to AMP, which is not produced during ATP hydrolysis by these enzymes.
Andrea A, Putnam, Eckhard, Jankowsky
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