The RNA helicase domain of NAT10 promotes the biogenesis of hypomodified ribosomes to enhance cancer cell proliferation [PDF]
Nature CommunicationsN-acetyltransferase 10 (NAT10) is a multifunctional enzyme that harbors RNA acetyltransferase and RNA helicase domains and has emerged as a therapeutic vulnerability in solid and hematological malignancies.
Mahmood H. Dalhat +23 more
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Viruses, 2022 Dengue virus replicates its single-stranded RNA genome in membrane-bound complexes formed on the endoplasmic reticulum, where viral non-structural proteins (NS) and RNA co-localize.
Satyamurthy Kundharapu +1 more
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Genome-wide comparative in silico analysis of the RNA helicase gene family in Zea mays and Glycine max: a comparison with Arabidopsis and Oryza sativa. [PDF]
PLoS ONE, 2013 RNA helicases are enzymes that are thought to unwind double-stranded RNA molecules in an energy-dependent fashion through the hydrolysis of NTP. RNA helicases are associated with all processes involving RNA molecules, including nuclear transcription ...
Ruirui Xu +3 more
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Structural basis of the T4 bacteriophage primosome assembly and primer synthesis
Nature Communications, 2023 The T4 bacteriophage gp41 helicase and gp61 primase assemble into a primosome to couple DNA unwinding with RNA primer synthesis for DNA replication. How the primosome is assembled and how the primer length is defined are unclear.
Xiang Feng +4 more
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The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity
iScience, 2020 Summary: Members of the DEAD-box helicase family are involved in all fundamental processes of RNA metabolism, and as such, their malfunction is associated with various diseases.
Maria J. Marcaida +8 more
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HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete. [PDF]
PLoS Pathogens, 2013 The Lyme disease spirochete Borrelia burgdorferi must differentially express genes and proteins in order to survive in and transit between its tick vector and vertebrate reservoir. The putative DEAH-box RNA helicase, HrpA, has been recently identified as
Aydan Salman-Dilgimen +4 more
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RNA helicase domains of viral origin in proteins of insect retrotransposons: possible source for evolutionary advantages [PDF]
PeerJ, 2017 Recently, a novel phenomenon of horizontal gene transfer of helicase-encoding sequence from positive-stranded RNA viruses to LINE transposons in insect genomes was described.
Sergey Y. Morozov +2 more
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The EuroBiotech Journal, 2022 The pathogenic RNA virus that infects human beings contains the RNA helicase enzyme, responsible for the replication of the viral genome. The enzyme is used as a suitable target against which the drug molecule acts.
Satpathy R, Acharya S
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Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer
Frontiers in Oncology, 2023 Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately, this disease is changing rapidly to a younger age, and in a more advanced stage
Bichun Zheng +4 more
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Helicase: A genetic tool for providing stress tolerance in plants
Plant Stress, 2023 Alteration of stress (abiotic and biotic) constitutes one of the major problems for normal plants health. In the present scenario, new molecular tools are broadly utilized to improve stress tolerance and high-yielding crop plants.
Monalisha Das Mohapatra +3 more
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