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Architecture of a SARS-CoV-2 mini replication and transcription complex
Nature Communications, 2020 SARS-CoV-2 virus replication and transcription is mediated by the replication and transcription complex (RTC) that is composed of 16 non-structural proteins (nsp). Here, the authors present the cryo-EM structure of a SARS-CoV-2 mini RTC consisting of the
Liming Yan +12 more
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DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection
Frontiers in Cellular and Infection Microbiology, 2021 Previous studies have shown that DEAD (Asp-Glu-Ala-Asp)-box RNA helicases play important roles in viral infection, either as cytosolic sensors of pathogenic molecules or as essential host factors against viral infection.
Rui Zhang +9 more
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, 2013 EC number 3.6.4.13 Systematic name ATP phosphohydrolase (RNA helix unwinding) Recommended name RNA helicase Synonyms 1a NTPase/helicase [5] ATP/dATP-dependent RNA helicase [32] ATPase [1,36] ATPase/RNA helicase [32] ATPase/helicase [36,41] BMV 1a protein [5] BmL3-helicase [32] Brr2p [50] DBP2 [30] DDX17 [12] DDX19 [56] DDX25 [
Schomburg, Dietmar, Schomburg, Ida
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Frontiers in Oncology, 2022 BackgroundLiver hepatocellular carcinoma (LIHC), one of the most common primary malignancies, exhibits high levels of molecular and clinical heterogeneity.
Xi Chen +22 more
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RNA helicase A is essential for normal gastrulation [PDF]
Proceedings of the National Academy of Sciences, 1998 RNA helicase A (RHA) is the human homologue of the Drosophila maleless protein, an essential factor for the development of male flies. Recently, it was shown that RHA cooperates with the cAMP-responsive element in mediating the cAMP-dependent transcriptional activation of a number of genes.
C G, Lee +5 more
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Docking studies of Pakistani HCV NS3 helicase: a possible antiviral drug target.
PLoS ONE, 2014 The nonstructural protein 3 (NS3) of hepatitis C virus (HCV) helicase is believed to be essential for viral replication and has become an attractive target for the development of antiviral drugs.
Kaneez Fatima +6 more
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Structure of frequency-interacting RNA helicase from Neurospora crassa reveals high flexibility in a domain critical for circadian rhythm and RNA surveillance. [PDF]
PLoS ONE, 2018 The FRH (frequency-interacting RNA helicase) protein is the Neurospora crassa homolog of yeast Mtr4, an essential RNA helicase that plays a central role in RNA metabolism as an activator of the nuclear RNA exosome. FRH is also a required component of the
Yalemi Morales +3 more
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RNA helicases and remodeling proteins
Current Opinion in Chemical Biology, 2011 It is becoming increasingly clear that RNA molecules play a major role in all aspects of metabolism. The conformational state and stability of RNA are controlled by RNA remodeling proteins, which are ubiquitous motor proteins in the cell. Here, we review advances in our understanding of the structure and function of three major structural families of ...
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The RNA helicase DDX5 is a reprogramming roadblock [PDF]
Stem Cell Investigation, 2017 The reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is a major challenge for medical applications such as regenerative medicine since iPSCs can be used to generate different types of functional differentiated cells. Up to now, strategies aiming at reprogramming somatic cells have been mainly conducted toward the targeting of ...
Cyril F, Bourgeois, Didier, Auboeuf
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PLoS ONE, 2019 Yersinia pseudotuberculosis is an important foodborne pathogen threatening modern food safety due to its ability to survive and grow at low temperatures. DEAD-box RNA helicase CsdA has been shown to play an important role in the low-temperature growth of
Xiaojie Jiang +3 more
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