Results 1 to 10 of about 1,270,992 (292)
DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy [PDF]
Cells, 2021 Cell cycle is regulated through numerous signaling pathways that determine whether cells will proliferate, remain quiescent, arrest, or undergo apoptosis. Abnormal cell cycle regulation has been linked to many diseases.
Lu Zhang, Xiaogang Li
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Regulation and mechanisms of action of RNA helicases [PDF]
RNA BiologyRNA helicases are an evolutionary conserved class of nucleoside triphosphate dependent enzymes found in all kingdoms of life. Their cellular functions range from transcription regulation up to maintaining genomic stability and viral defence.
Nina Lang +2 more
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DEAD-Box RNA Helicases and Genome Stability. [PDF]
Genes (Basel), 2021 DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome ...
Cargill M, Venkataraman R, Lee S.
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RNA folding and functions of RNA helicases in ribosome biogenesis [PDF]
RNA Biology, 2022 Eukaryotic ribosome biogenesis involves the synthesis of ribosomal RNA (rRNA) and its stepwise folding into the unique structure present in mature ribosomes.
Valentin Mitterer, Brigitte Pertschy
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RNA helicases in RNA decay. [PDF]
Biochem Soc Trans, 2018 RNA molecules have the tendency to fold into complex structures or to associate with complementary RNAs that exoribonucleases have difficulties processing or degrading.
Khemici V, Linder P.
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Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly. [PDF]
Nat Commun, 2023 The U2 snRNP recognizes the intron during spliceosome assembly. Here the authors report the high-resolution structures of two assembly precursors of human U2 snRNP and reveal that the RNA helicases DDX42 and DDX46 are mutually exclusive in terms of SF3B1-
Yang F +7 more
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Host Cellular RNA Helicases Regulate SARS-CoV-2 Infection. [PDF]
J Virol, 2022 SARS-CoV-2 has a large RNA genome, of approximately 30 kb. To regulate and maintain such a large viral RNA genome, host RNA helicases may be involved in SARS-CoV-2 replication. ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the
Ariumi Y.
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DDX RNA helicases: key players in cellular homeostasis and innate antiviral immunity. [PDF]
J VirolRNA helicases are integral in RNA metabolism, performing important roles in cellular homeostasis and stress responses. In particular, the DExD/H-box (DDX) helicase family possesses a conserved catalytic core that binds structural features rather than ...
Tapescu I, Cherry S.
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Untangling the roles of RNA helicases in antiviral innate immunity. [PDF]
PLoS Pathog, 2021 One of the first layers of protection that metazoans put in place to defend themselves against viruses rely on the use of proteins containing DExD/H-box helicase domains.
Baldaccini M, Pfeffer S.
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