Results 1 to 10 of about 27,859 (170)

Genome-wide identification, in silico characterization and expression analysis of the RNA helicase gene family in chickpea (C. arietinum L.)

Scientific Reports, 2022
The RNA helicases are an important class of enzymes which are known to influence almost every aspect of RNA metabolism. The majority of RNA helicases belong to the SF2 (superfamily 2) superfamily, members of which are further categorized into three ...
Sheel Yadav, Yashwant K. Yadava, Deshika Kohli, Shashi Meena, Gopal Kalwan, C. Bharadwaj, Kishor Gaikwad, Ajay Arora, P. K. Jain   +8 more
doaj   +1 more source

Caspase-mediated DDX46 cleavage unchains antiviral immunity

mBio
DEAD/H-box RNA helicases are critical regulators of host antiviral innate immunity. In this study, we utilized an RNA-binding protein knockout sub-library to identify DDX46, a member of the DEAD/H-box RNA helicase family, as an essential proviral host ...
Yanfeng Liu, Zhongyuan Liu, Xiaoqing Ou, Feiyang Zhao, Jingrui Wang, Yang Qu, Xusheng Qiu, Ying Liao, Lei Tan, Cuiping Song, Chan Ding, Yingjie Sun   +11 more
doaj   +1 more source

Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis

Cell Reports, 2015
Cytoplasmic RNA granules play a central role in mRNA metabolism, but the importance of mitochondrial RNA granules remains relatively unexplored. We characterized their proteome and found that they contain a large toolbox of proteins dedicated to RNA ...
Hana Antonicka, Eric A. Shoubridge
doaj   +1 more source

Role of DEAD/DEAH-box helicases in immunity, infection and cancers

Cell Communication and Signaling
DEAD/DEAH-box helicases (DDX) are integral RNA-binding proteins within the RNA helicase superfamily 2 (SF2), characterized by distinct DEAD (Asp-Glu-Ala-Asp) and DEAH (Asp-Glu-Ala-His) motifs.
Rex Devasahayam Arokia Balaya, Saptami Kanekar, Shreya Kumar, Richard K. Kandasamy   +3 more
doaj   +1 more source

Structural insights into the mechanism of the DEAH-box RNA helicase Prp43

eLife, 2017
The DEAH-box helicase Prp43 is a key player in pre-mRNA splicing as well as the maturation of rRNAs. The exact modus operandi of Prp43 and of all other spliceosomal DEAH-box RNA helicases is still elusive.
Marcel J Tauchert, Jean-Baptiste Fourmann, Reinhard Lührmann, Ralf Ficner   +3 more
doaj   +1 more source

Orchestrating innate immunity through RNA editing and helicase activity: ADAR1, dsRNA sensors, and tumor immune evasion

Frontiers in Cell and Developmental Biology
Dysregulated dsRNA editing and RNA metabolism in cancer contribute to immune evasion, highlighting the critical role of RNA structural regulation in disease.
Moeko Minakuchi, Joseph M. Salvino, Jessie Villanueva   +2 more
doaj   +1 more source

Zebrafish P54 RNA helicases are cytoplasmic granule residents that are required for development and stress resilience

Biology Open, 2016
Stress granules are cytoplasmic foci that directly respond to the protein synthesis status of the cell. Various environmental insults, such as oxidative stress or extreme heat, block protein synthesis; consequently, mRNA will stall in translation, and ...
Cecilia Zampedri, Maryana Tinoco-Cuellar, Samantha Carrillo-Rosas, Abigail Diaz-Tellez, Jose Luis Ramos-Balderas, Francisco Pelegri, Ernesto Maldonado   +6 more
doaj   +1 more source

MOV10L1 Binds RNA G-Quadruplex in a Structure-Specific Manner and Resolves It More Efficiently Than MOV10

iScience, 2019
Summary: MOV10L1 and its paralog MOV10 are evolutionally conserved RNA helicases involved in distinct RNA regulatory pathways. The testis-specific MOV10L1 is essential for spermatogenesis and PIWI-interacting RNAs biogenesis, whereas MOV10 is ubiquitous ...
Xia Zhang, Lina Yu, Shasha Ye, Jie Xie, Xingxu Huang, Ke Zheng, Bo Sun   +6 more
doaj   +1 more source

RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers

Frontiers in Genetics, 2015
RECQL1 and WRN helicases in the human RecQ helicase family participate in maintaining genome stability, DNA repair, replication and recombination pathways in the cell cycle.
Kazunobu eFutami, Yasuhiro eFuruichi
doaj   +1 more source

Split-APEX implicates splicing factor SRSF1 and splicing helicases in ribosomal biogenesis

Frontiers in Molecular Biosciences
SR proteins are RNA-binding proteins with one or two RNA recognition motif (RRM)-type RNA-binding domains and a C-terminal region rich in arginine-serine dipeptides. They function in cellular processes ranging from transcription to translation.
Vasileios Paschalis, Vasileios Paschalis, Max F. K. Wills, Max F. K. Wills, Philippe De Gusmao Araujo, Philippe De Gusmao Araujo, Christian Lucas, Christian Lucas, Sumera Tubasum, Sumera Tubasum, Shijie Cui, Shijie Cui, Hesna Kara, Hesna Kara, Carlos Bueno-Alejo, Carlos Bueno-Alejo, Marina Santana-Vega, Andrea Taladriz-Sender, Zhengyun Zhao, Alexander Axer, Cyril Dominguez, Cyril Dominguez, Alasdair W. Clark, Glenn A. Burley, Andrew J. Hudson, Andrew J. Hudson, Ian C. Eperon, Ian C. Eperon   +27 more
doaj   +1 more source