Results 1 to 10 of about 25,401,718 (281)
TRIM24 is an insulin-responsive regulator of P-bodies [PDF]
Nature Communications, 2022 Insulin promotes hepatic lipogenesis, though underlying regulation remains unclear. Here the authors show that insulin translocates TRIM24 from the nucleus into cytosolic P-bodies to stabilise hepatic Pparγ mRNA, and that inactivation of TRIM24 promotes ...
Wen Wei +13 more
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Composition and function of P bodies in Arabidopsis thaliana [PDF]
Frontiers in Plant Science, 2014 mRNA accumulation is tightly regulated by diverse molecular pathways. The identification and characterization of enzymes and regulatory proteins involved in controlling the fate of mRNA offers the possibility to broaden our understanding of ...
Luis David Maldonado-Bonilla
doaj +5 more sources
Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies [PDF]
Journal of Extracellular Vesicles, 2020 Pregnancy is a unique situation, in which placenta-derived small extracellular vesicles (sEVs) may communicate with maternal and foetal tissues. While relevant to homoeostatic and pathological functions, the mechanisms underlying sEV entry and cargo ...
Hui Li +6 more
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Context-dependent deposition and regulation of mRNAs in P-bodies [PDF]
eLife, 2018 Cells respond to stress by remodeling their transcriptome through transcription and degradation. Xrn1p-dependent degradation in P-bodies is the most prevalent decay pathway, yet, P-bodies may facilitate not only decay, but also act as a storage ...
Congwei Wang +5 more
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Energy stress promotes P-bodies formation via lysine-63-linked polyubiquitination of HAX1 [PDF]
The EMBO JournalEnergy stress, characterized by the reduction of intracellular ATP, has been implicated in various diseases, including cancer. Here, we show that energy stress promotes the formation of P-bodies in a ubiquitin-dependent manner. Upon ATP depletion, the E3
Wanqi Zhan +13 more
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Prolonged Pseudohypoxia Targets Ambra1 mRNA to P-Bodies for Translational Repression. [PDF]
PLoS ONE, 2015 Hypoxia has been associated with several pathological conditions ranging from stroke to cancer. This condition results in the activation of autophagy, a cyto-protective response involving the formation of double-membraned structures, the autophagosomes ...
Somayeh Pourpirali +5 more
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P439: RNA SEQUESTRATION IN P-BODIES PROMOTES LEUKEMIA ONSET AND PROGRESSION [PDF]
HemaSphere, 2023 Ludovica Proietti +13 more
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Disease Models & Mechanisms, 2022 RNA regulation in mammalian cells requires complex physical compartmentalisation, using structures thought to be formed by liquid-liquid phase separation. Disruption of these structures is implicated in numerous degenerative diseases.
Selma Gulyurtlu +6 more
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Phytochrome A Mediates the Disassembly of Processing Bodies in Far-Red Light
Frontiers in Plant Science, 2022 Phytochromes are red- and far-red light receptors that control the growth and development of plants, enabling them to respond adequately to changing light conditions. It has been shown that halted mRNAs stored in RNA granules called processing bodies are
Philipp Schwenk +3 more
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Cells, 2022 Cells possess membraneless ribonucleoprotein (RNP) granules, including stress granules, processing bodies, Cajal bodies, or paraspeckles, that play physiological or pathological roles.
Pureum Jeon +3 more
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