Results 1 to 10 of about 645,325 (150)
TRIM24 is an insulin-responsive regulator of P-bodies [PDF]
Nature Communications, 2022 Insulin promotes hepatic lipogenesis, though underlying regulation remains unclear. Here the authors show that insulin translocates TRIM24 from the nucleus into cytosolic P-bodies to stabilise hepatic Pparγ mRNA, and that inactivation of TRIM24 promotes ...
Wen Wei +13 more
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Composition and function of P bodies in Arabidopsis thaliana [PDF]
Frontiers in Plant Science, 2014 mRNA accumulation is tightly regulated by diverse molecular pathways. The identification and characterization of enzymes and regulatory proteins involved in controlling the fate of mRNA offers the possibility to broaden our understanding of ...
Luis David Maldonado-Bonilla
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Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies [PDF]
Journal of Extracellular Vesicles, 2020 Pregnancy is a unique situation, in which placenta-derived small extracellular vesicles (sEVs) may communicate with maternal and foetal tissues. While relevant to homoeostatic and pathological functions, the mechanisms underlying sEV entry and cargo ...
Hui Li +6 more
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Deadenylation and P-bodies. [PDF]
Adv Exp Med Biol, 2013 Deadenylation is the major step in triggering mRNA decay and results in mRNA translation inhibition in eukaryotic cells. Therefore, it is plausible that deadenylation also induces the mRNP remodeling required for formation of GW bodies or RNA processing bodies (P-bodies), which harbor translationally silenced mRNPs.
Chen CY, Shyu AB.
europepmc +4 more sources
Mammalian stress granules and P bodies at a glance. [PDF]
J Cell Sci, 2020 ABSTRACT Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-based cellular compartments that assemble in response to stress. SGs and PBs form through liquid–liquid phase separation that is driven by high local concentrations of key proteins and RNAs, both of which dynamically shuttle between the granules
Riggs CL +3 more
europepmc +3 more sources
P-Bodies: Composition, Properties, and Functions. [PDF]
Biochemistry, 2018 Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid droplets.
Luo Y, Na Z, Slavoff SA.
europepmc +4 more sources
Stress granules, P-bodies and cancer. [PDF]
Biochim Biophys Acta, 2015 Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize post-transcriptional control mechanisms to re-program gene expression in ways that enhance cell survival. Stress granules and processing bodies are RNA-containing granules that contribute to this process by modulating cellular signaling pathways, metabolic ...
Anderson P, Kedersha N, Ivanov P.
europepmc +4 more sources
Context-dependent deposition and regulation of mRNAs in P-bodies [PDF]
eLife, 2018 Cells respond to stress by remodeling their transcriptome through transcription and degradation. Xrn1p-dependent degradation in P-bodies is the most prevalent decay pathway, yet, P-bodies may facilitate not only decay, but also act as a storage ...
Congwei Wang +5 more
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Energy stress promotes P-bodies formation via lysine-63-linked polyubiquitination of HAX1 [PDF]
The EMBO JournalEnergy stress, characterized by the reduction of intracellular ATP, has been implicated in various diseases, including cancer. Here, we show that energy stress promotes the formation of P-bodies in a ubiquitin-dependent manner. Upon ATP depletion, the E3
Wanqi Zhan +13 more
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GW-Bodies and P-Bodies Constitute Two Separate Pools of Sequestered Non-Translating RNAs. [PDF]
PLoS ONE, 2016 Non-translating RNAs that have undergone active translational repression are culled from the cytoplasm into P-bodies for decapping-dependent decay or for sequestration.
Prajal H Patel +2 more
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