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RNA Granules: A View from the RNA Perspective
Molecules, 2020 RNA granules are ubiquitous. Composed of RNA-binding proteins and RNAs, they provide functional compartmentalization within cells. They are inextricably linked with RNA biology and as such are often referred to as the hubs for post-transcriptional ...
Siran Tian +2 more
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Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates
eLife, 2021 Exosomes may mediate cell-to-cell communication by transporting various proteins and nucleic acids to neighboring cells. Some protein and RNA cargoes are significantly enriched in exosomes.
Xiao-Man Liu, Liang Ma, Randy Schekman
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Intracellular trafficking and dynamics of P bodies [PDF]
Prion, 2008 RNAs are exported from the nucleus to the cytoplasm, where they undergo translation and produce proteins needed for the cellular life cycle. Some mRNAs are targeted by different RNA decay mechanisms and thereby undergo degradation. The 5'-->3' degradation machinery localizes to cytoplasmic complexes termed P bodies (PBs). They function in RNA turnover,
Adva, Aizer, Yaron, Shav-Tal
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Correction: Context-dependent deposition and regulation of mRNAs in P-bodies
eLife, 2018 Congwei Wang +5 more
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Close-In Substellar Companions and the Formation of sdB-Type Close Binary Stars
Acta Polytechnica CTU Proceedings, 2015 The sdB-type close binaries are believed to have experienced a common-envelope phase and may evolve into cataclysmic binaries (CVs). About 10% of all known sdB binaries are eclipsing binaries consisting of very hot subdwarf primaries and low-mass ...
L. Y. Zhu +4 more
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Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation
Biomolecules, 2020 Stress granules (SGs) are hypothesized to facilitate TAR DNA-binding protein 43 (TDP-43) cytoplasmic mislocalization and aggregation, which may underly amyotrophic lateral sclerosis pathology.
Nikita Fernandes +6 more
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Characterization of Hantavirus N Protein Intracellular Dynamics and Localization
Viruses, 2022 Hantaviruses are enveloped viruses that possess a tri-segmented, negative-sense RNA genome. The viral S-segment encodes the multifunctional nucleocapsid protein (N), which is involved in genome packaging, intracellular protein transport, immunoregulation,
Robert-William Welke +9 more
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Hepatitis C Virus Infection Alters P-Body Composition but Is Independent of P-Body Granules [PDF]
Journal of Virology, 2012 ABSTRACTProcessing bodies (P-bodies) are highly dynamic cytoplasmic granules conserved among eukaryotes. They are present under normal growth conditions and contain translationally repressed mRNAs together with proteins from the mRNA decay and microRNA (miRNA) machineries.
Gemma, Pérez-Vilaró +3 more
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Frontiers in Cell and Developmental Biology, 2021 The hypoxic microenvironment is beneficial to the metastasis but not to the proliferation of cancer cells. However, the mechanisms regarding to hypoxia differentially regulating cancer metastasis and proliferation are largely unknown.
Mingjiao Weng +20 more
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1st International Symposium on Stress-Associated RNA Granules in Human Disease and Viral Infection
Viruses, 2014 In recent years, important linkages have been made between RNA granules and human disease processes. On June 8-10 of this year, we hosted a new symposium, dubbed the 1st International Symposium on Stress-Associated RNA Granules in Human Disease and Viral
Bruce W. Banfield +2 more
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