Results 21 to 30 of about 645,423 (346)

Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates

eLife, 2021
Exosomes may mediate cell-to-cell communication by transporting various proteins and nucleic acids to neighboring cells. Some protein and RNA cargoes are significantly enriched in exosomes.
Xiao-Man Liu, Liang Ma, Randy Schekman
doaj   +1 more source

Correction: Context-dependent deposition and regulation of mRNAs in P-bodies

eLife, 2018
Congwei Wang, Fabian Schmich, Sumana Srivatsa, Julie Weidner, Niko Beerenwinkel, Anne Spang   +5 more
doaj   +2 more sources

Hepatitis C Virus Infection Alters P-Body Composition but Is Independent of P-Body Granules [PDF]

Journal of Virology, 2012
ABSTRACTProcessing bodies (P-bodies) are highly dynamic cytoplasmic granules conserved among eukaryotes. They are present under normal growth conditions and contain translationally repressed mRNAs together with proteins from the mRNA decay and microRNA (miRNA) machineries.
Gemma, Pérez-Vilaró, Nicoletta, Scheller, Verónica, Saludes, Juana, Díez   +3 more
openaire   +2 more sources

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis [PDF]

, 2019
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored.
Aigner, S., Anselmo, A., Brumbaugh, J., Charlton, J., Clement, K., Clowers, K., de Kort, M., Di Stefano, B., Gerli, M., Gu, H., Gygi, S., Haggerty, C., Hochedlinger, K., Huebner, A., Ji, F., Lipchina, I., Luo, E., Meissner, A., Pulice, J., Rabano Jiménez, I., Sadreyev, R., Yeo, G.   +21 more
core   +3 more sources

Close-In Substellar Companions and the Formation of sdB-Type Close Binary Stars

Acta Polytechnica CTU Proceedings, 2015
The sdB-type close binaries are believed to have experienced a common-envelope phase and may evolve into cataclysmic binaries (CVs). About 10% of all known sdB binaries are eclipsing binaries consisting of very hot subdwarf primaries and low-mass ...
L. Y. Zhu, S. B. Qian, E.-G. Zhao, E. Fernández Lajús, Z.-T. Han   +4 more
doaj   +1 more source

Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation

Biomolecules, 2020
Stress granules (SGs) are hypothesized to facilitate TAR DNA-binding protein 43 (TDP-43) cytoplasmic mislocalization and aggregation, which may underly amyotrophic lateral sclerosis pathology.
Nikita Fernandes, Luke Nero, Shawn M. Lyons, Pavel Ivanov, Telsa M. Mittelmeier, Timothy A. Bolger, J. Ross Buchan   +6 more
doaj   +1 more source

Characterization of Hantavirus N Protein Intracellular Dynamics and Localization

Viruses, 2022
Hantaviruses are enveloped viruses that possess a tri-segmented, negative-sense RNA genome. The viral S-segment encodes the multifunctional nucleocapsid protein (N), which is involved in genome packaging, intracellular protein transport, immunoregulation,
Robert-William Welke, Hannah Sabeth Sperber, Ronny Bergmann, Amit Koikkarah, Laura Menke, Christian Sieben, Detlev H. Krüger, Salvatore Chiantia, Andreas Herrmann, Roland Schwarzer   +9 more
doaj   +1 more source

A role for Q/N-rich aggregation-prone regions in P-body localization [PDF]

, 2008
P-bodies are cytoplasmic foci that are sites of mRNA degradation and translational repression. It is not known what causes the accumulation of RNA degradation factors in P-bodies, although RNA is required.
Alexander, R.D., Beggs, J.D., Reijns, M.A.M., Spiller, M.P.   +3 more
core   +1 more source

Hypoxia-Induced LIN28A mRNA Promotes the Metastasis of Colon Cancer in a Protein-Coding-Independent Manner

Frontiers in Cell and Developmental Biology, 2021
The hypoxic microenvironment is beneficial to the metastasis but not to the proliferation of cancer cells. However, the mechanisms regarding to hypoxia differentially regulating cancer metastasis and proliferation are largely unknown.
Mingjiao Weng, Yukuan Feng, Yan He, Weiwei Yang, Jing Li, Yuanyuan Zhu, Tianzhen Wang, Chuhan Wang, Xiao Zhang, Yu Qiao, Qi Li, Lingyu Zhao, Shuangshu Gao, Lei Zhang, Yiqi Wu, Ran Zhao, Guangyu Wang, Zhiwei Li, Xiaoming Jin, Tongsen Zheng, Xiaobo Li   +20 more
doaj   +1 more source

Defects in the Secretory Pathway and High Ca2+ Induce Multiple P-bodies [PDF]

, 2010
Monitoring Editor: Reid Gilmore mRNA is sequestered and turned over in cytoplasmic processing bodies (PBs), which are induced by various cellular stresses. Unexpectedly, in S.
Cornelia Kilchert, Julie Weidner, Cristina Prescianotto-Baschong, Anne Spang, Reid Gilmore, Anderson J. R., Andrei M. A., Aronov S., Batiza A. F., Bi J., Bouveret E., Buchan J. R., Chowdhury A., Coller J., Cox J. S., De Filippi L., de la Cruz J., Decker C. J., Decker C. J., Deloche O., Dunckley T., Erdeniz N., Eulalio A., Ferraiuolo M. A., Franks T. M., Geiser J. R., Grousl T., Gueldener U., Hayashi M., Heath V. L., Hohmann S., Hoyle N. P., Kedersha N., Kimata Y., Knop M., Lee K. S., Matsumoto T. K., Nelson K. K., Ohya Y., Parker R., Patil C. K., Prescianotto-Baschong C., Reijns M. A., Romero-Santacreu L., Salgado-Garrido J., Schmelzle T., Schmid M., Sherman F., Sheth U., Sidrauski C., Sikorski R. S., Spang A., Swisher K.D., Teixeira D., Tharun S., Tharun S., Tharun S., Van Wuytswinkel O., Wilczynska Z., Wilhelm J. E.   +59 more
core   +1 more source