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1st International Symposium on Stress-Associated RNA Granules in Human Disease and Viral Infection

Viruses, 2014
In recent years, important linkages have been made between RNA granules and human disease processes. On June 8-10 of this year, we hosted a new symposium, dubbed the 1st International Symposium on Stress-Associated RNA Granules in Human Disease and Viral
Bruce W. Banfield, Andrew J. Mouland, Craig McCormick   +2 more
doaj   +1 more source

General (p,q)-mixed projection bodies

Open Mathematics, 2020
In this article, the general (p,q)-mixed projection bodies are introduced. Then, some basic properties of the general (p,q)-mixed projection bodies are discussed, and the extreme values of volumes of the general (p,q)-mixed projection bodies and their ...
Feng Yibin, Zhou Yanping
doaj   +1 more source

Quantifying argonaute proteins in and out of GW/P-bodies: Implications in microRNA activities [PDF]

, 2018
MicroRNAs (miRNAs) are a class of ∼22nt non-coding RNAs that regulate the translational potential and stability of mRNAs. Though constituting only 1-4% of human genes, miRNAs are predicted to regulate more than 60% of all mRNAs.
Leung, Anthony K. L., Sharp, Phillip A.
core   +1 more source

RNA sequestration in P-bodies sustains myeloid leukaemia. [PDF]

Nat Cell Biol
Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through genome-wide CRISPR screens in normal and malignant haematopoietic progenitors.
Kodali S, Proietti L, Valcarcel G, López-Rubio AV, Pessina P, Eder T, Shi J, Jen A, Lupión-Garcia N, Starner AC, Bartels MD, Cui Y, Sands CM, Planas-Riverola A, Martínez A, Velasco-Hernandez T, Tomás-Daza L, Alber B, Manhart G, Mayer IM, Kollmann K, Fatica A, Menendez P, Shishkova E, Rau RE, Javierre BM, Coon J, Chen Q, Van Nostrand EL, Sardina JL, Grebien F, Di Stefano B.   +31 more
europepmc   +5 more sources

Constructing P-bodies [PDF]

The Journal of Cell Biology, 2007
![Graphic][1] Construction of P-bodies (white) stops in the absence of Edc3p (right). Putting together a P-body requires both building blocks and glue. [Decker et al.][2] now show that a yeast mRNA decapping activator protein contributes to both jobs: it forms part of the ...
openaire   +1 more source

P-Bodies React to Stress and Nonsense [PDF]

Cell, 2006
P-bodies are specialized cytoplasmic compartments where translational repression and mRNA turnover may occur. Findings in this issue of Cell provide evidence that P-bodies are sites of "mRNA purgatory." Bhattacharyya et al. (2006) reveal that normal mRNA can be released from P-bodies and translated into protein in response to stress.
Bruno, Ivone, Wilkinson, Miles F.
openaire   +2 more sources

Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. [PDF]

, 2016
Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. Overexpression of
Aguado, Andrea, Anant, Shrikant, Blanco, Fernando F., Brody, Jonathan R., Dixon, Dan A., Meisner-Kober, Nicole, Padhye, Subhash, Preet, Ranjan, Stevens, Laura E., Vishwakarma, Vikalp, Vyas, Alok, Weir, Scott J., Xu, Liang   +12 more
core   +2 more sources

Intracellular trafficking and dynamics of P bodies [PDF]

Prion, 2008
RNAs are exported from the nucleus to the cytoplasm, where they undergo translation and produce proteins needed for the cellular life cycle. Some mRNAs are targeted by different RNA decay mechanisms and thereby undergo degradation. The 5'-->3' degradation machinery localizes to cytoplasmic complexes termed P bodies (PBs). They function in RNA turnover,
Adva, Aizer, Yaron, Shav-Tal
openaire   +2 more sources

Heterologous expression screens in Nicotiana benthamiana identify a candidate effector of the wheat Yellow Rust Pathogen that associates with processing bodies [PDF]

, 2016
Rust fungal pathogens of wheat (Triticum spp.) affect crop yields worldwide. The molecular mechanisms underlying the virulence of these pathogens remain elusive, due to the limited availability of suitable molecular genetic research tools.
A Bombarely, A Eulalio, A Eulalio, A Hubbard, A Steffens, A Weiberg, B Petre, B Petre, B Petre, Benjamin Petre, CH Wu, Cécile Lorrain, D Cantu, D Cantu, Diane G. O. Saunders, DP Garnica, EKL Chan, F Martin, G Pérez-Vilaró, J Win, J Xu, J Xu, Jan Sklenar, JL Dangl, JM Beddow, Joe Win, Ksenia V. Krasileva, LC Reineke, LD Maldonado-Bonilla, M Pais, Mark Gijzen, ME Roux, MM Goodin, MS Mukhtar, NM Upadhyaya, PD Spanu, PF Sarris, PN Dodds, R Dean, S Cesari, S Emanuelle, SA Hogenhout, Sophien Kamoun, Sébastien Duplessis, W Chen, W Zheng, Y Ariumi, Y Qiao   +47 more
core   +5 more sources

The 5'-3' exoribonuclease pacman is required for epithelial sheet sealing in Drosophila and genetically interacts with the phosphatase puckered [PDF]

, 2008
Background information. Ribonucleases have been well studied in yeast and bacteria, but their biological significance to developmental processes in multicellular organisms is not well understood.
Browne, Cathy, Grima, Dominic P, Newbury, Sarah F, Okada, Yoshio, Seago, Julian, Sullivan, Melanie, Wan, Kay Chong, Zabolotskaya, Maria V   +7 more
core   +2 more sources