The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. [PDF]
, 2015 Previously, we identified ISRIB as a potent inhibitor of the integrated stress response (ISR) and showed that ISRIB makes cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (Sidrauski et al., 2013).
Ingolia, Nicholas T +3 more
core +2 more sources
Expression of the CCCH-tandem zinc finger protein gene OsTZF5 under a stress-inducible promoter mitigates the effect of drought stress on rice grain yield under field conditions [PDF]
, 2020 Increasing drought resistance without sacrificing grain yield remains an ongoing challenge in crop improvement. In this study, we report that Oryza sativa CCCH‐tandem zinc finger protein 5 (OsTZF5) can confer drought resistance and increase grain yield ...
Dedicova, Beata +10 more
core +1 more source
The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids. [PDF]
, 2017 Trypanosomatid protozoa are unusual eukaryotes that are well known for having unusual ways of controlling their gene expression. The lack of a refined mode of transcriptional control in these organisms is compensated by several post-transcriptional ...
Campbell, David A +3 more
core +2 more sources
Molecular medicine of microRNAs: structure, function and implications for diabetes [PDF]
, 2008 MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in length. In humans, up to 3% of all genes are estimated to encode these evolutionarily conserved sequences.
Duncan +5 more
core +1 more source
Mammalian stress granules and P bodies at a glance. [PDF]
J Cell Sci, 2020 ABSTRACT Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-based cellular compartments that assemble in response to stress. SGs and PBs form through liquid–liquid phase separation that is driven by high local concentrations of key proteins and RNAs, both of which dynamically shuttle between the granules
Riggs CL +3 more
europepmc +3 more sources
Properties of Stress Granule and P-Body Proteomes [PDF]
Molecular Cell, 2019 Stress granules and P-bodies are cytosolic biomolecular condensates that dynamically form by the phase separation of RNAs and proteins. They participate in translational control and buffer the proteome. Upon stress, global translation halts and mRNAs bound to the translational machinery and other proteins coalesce to form stress granules (SGs ...
Ji-Young, Youn +6 more
openaire +2 more sources
YAP/TAZ enhance P-body formation to promote tumorigenesis
eLife, 2023 Abstract The role of Processing bodies (P-bodies) in tumorigenesis and tumor progression is not well understood. Here, we showed that the oncogenes YAP/TAZ promote P-body formation in a series of cancer cell lines. Mechanistically, both transcriptional activation of the P- body-related genes SAMD4A, AJUBA, and WTIP and transcriptional ...
YueGui Guo +7 more
openaire +3 more sources
The 5' → 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development [PDF]
, 2012 XRN1 is a 5' → 3' processive exoribonuclease that degrades mRNAs after they have been decapped. It is highly conserved in all eukaryotes, including homologs in Drosophila melanogaster (Pacman), Caenorhabditis elegans (XRN1), and Saccharomyces cerevisiae (
Jones, Christopher Iain +2 more
core +1 more source
Frontiers in Molecular Biosciences, 2022 RNA is a vital biomolecule, the function of which is tightly spatiotemporally regulated. RNA organelles are biological structures that either membrane-less or surrounded by membrane.
Deepti Kailash Nabariya +3 more
doaj +1 more source
Relationship of GW/P-bodies with stress granules. [PDF]
Adv Exp Med Biol, 2013 Whereas P-bodies are intimately linked to the cytoplasmic RNA decay machinery, stress granules harbor stalled translation initiation complexes that accumulate upon stress-induced translation arrest. In this Chapter, we reflect on the relationship between P-bodies and stress granules.
Stoecklin G, Kedersha N.
europepmc +4 more sources