Results 61 to 70 of about 19,519,160 (297)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Embodied Vulnerability in Large-Scale Technical Systems: Vulnerable Dam Bodies, Water Bodies, and Human Bodies

, 2016
Challenging the modern ideal of human bodies as being in control both of bodies of nature and of the bodies of technology made to control nature, this chapter considers the vulnerability of large-scale hydropower dams and the intimate interdependencies ...
Öhman, May-Britt,, May-Britt Öhman
core   +1 more source

P-body-like condensates in the germline

Seminars in Cell & Developmental Biology
P-bodies are cytoplasmic condensates that accumulate low-translation mRNAs for temporary storage before translation or degradation. P-bodies have been best characterized in yeast and mammalian tissue culture cells. We describe here related condensates in the germline of animal models.
Cassani, Madeline, Seydoux, Geraldine
openaire   +2 more sources

Perplexing bodies: The putative roles of P-bodies in neurons [PDF]

RNA Biology, 2008
Processing bodies (P-bodies) have recently come to the fore as important cellular sites of mRNA degradation and translational silencing. Despite these central functions in the control of gene expression, the roles of P-bodies have only been characterized in a limited number of cell types and physiological contexts. Neurons are highly plastic cells that
ZEITELHOFER M, Macchi, Paolo, DAHM R.
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

White Book on Physical and Rehabilitation Medicine (PRM) in Europe. Chapter 11. Challenges and perspectives for the future of PRM

, 2018
In the context of the White Book of Physical and Rehabilitation Medicine (PRM) in Europe, this paper deals with the future perspectives of PRM in Europe according to the actual vision of the European Bodies.
Ceravolo Maria Gabriella, European Physical and Rehabilitation Medicine Bodies Alliance.   +1 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Inviscid mean flow through and around groups of bodies

, 2004
General estimates are derived for mean velocities through and around groups or arrays of fixed and moving bodies, in unbounded and bounded domains, which lie within a defined perimeter.
Hunt, J. C. R., Hunt, J.C.R., Eames, I, Eames, I. (author), S. E. BELCHER, Belcher, S. E., J. C. R. HUNT, Eames, I., Hunt, JCR, Belcher, S.E. (author), Hunt, J.C.R. (author), Belcher, S.E., Belcher, SE, I. EAMES   +13 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

More-than-leaky bodies: Existence as resistance

, 2023
Bodies, where ‘normal’ functions like digestion and excretion are enabled through non-human infrastructure (tubes, bags, and pumps), are more-than-leaky.
Budworth, P., Larrington-Spencer, H.
core