RNA Granules: A View from the RNA Perspective [PDF]
Molecules, 2020 RNA granules are ubiquitous. Composed of RNA-binding proteins and RNAs, they provide functional compartmentalization within cells. They are inextricably linked with RNA biology and as such are often referred to as the hubs for post-transcriptional ...
Siran Tian +2 more
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Who Regulates Whom? An Overview of RNA Granules and Viral Infections [PDF]
Viruses, 2016 After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the assembly of RNA granules.
Natalia Poblete-Durán +4 more
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Regulation of RNG105/caprin1 dynamics by pathogenic cytoplasmic FUS and TDP-43 in neuronal RNA granules modulates synaptic loss [PDF]
Heliyon, 2023 In neurodegenerative diseases, the condensation of FUS and TDP-43 with RNA granules in neurons is linked to pathology, including synaptic disorders. However, the effects of FUS and TDP-43 on RNA granule factors remain unclear.
Tomoyo Horio +3 more
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RNA Granules in Antiviral Innate Immunity: A Kaposi’s Sarcoma-Associated Herpesvirus Journey [PDF]
Frontiers in Microbiology, 2022 RNA granules are cytoplasmic, non-membranous ribonucleoprotein compartments that form ubiquitously and are often referred to as foci for post-transcriptional gene regulation.
Nishi R. Sharma, Zhi-Ming Zheng
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Plant RNA Regulatory Network and RNA Granules in Virus Infection [PDF]
Frontiers in Plant Science, 2017 Regulation of post-transcriptional gene expression on mRNA level in eukaryotic cells includes translocation, translation, translational repression, storage, mRNA decay, RNA silencing, and nonsense-mediated decay.
Kristiina Mäkinen +2 more
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Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules [PDF]
Biomolecules, 2020 Spatiotemporal translational regulation plays a key role in determining cell fate and function. Specifically, in neurons, local translation in dendrites is essential for synaptic plasticity and long-term memory formation.
Rie Ohashi, Nobuyuki Shiina
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Transcription arrest induces formation of RNA granules in mitochondria [PDF]
Life Science AllianceIn this study, the spatial distribution of mitochondrial-encoded RNAs is investigated and shows that upon transcription arrest, RNAs form granules that show protectivity for transcripts.
Katja G Hansen +4 more
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TDP-43 oxidation and PP1 crosstalk at RNA granule-mitochondria contact sites [PDF]
Nature CommunicationsInter-organelle contact sites are key hubs for organelle bidirectional crosstalk. However, how mitochondria and RNA granules interact at contact sites and its regulation by mitochondrial oxidative phosphorylation (OXPHOS) remain unclear.
Hannah E. Ball +2 more
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Regulation of RNA granules by FMRP and implications for neurological diseases [PDF]
Traffic, 2020 Gary J Bassell
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Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants. [PDF]
PLoS PathogensRecognition of double-stranded RNA (dsRNA) triggers antiviral defense mediated by PKR and OAS3/RNase L pathways through translational arrest and RNA decay. This is accompanied by assembly of distinct cytoplasmic ribonucleoprotein (RNP) condensates termed
Robert T Steinbock +16 more
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