Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB [PDF]
Nucleic Acids Research, 2019 Selma van Esveld +2 more
exaly +2 more sources
Viral Regulation of RNA Granules in Infected Cells [PDF]
Virologica Sinica, 2019 Mingzhou Chen, Zhi-Ming Zheng
exaly +2 more sources
Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila
Cell Reports, 2023 Summary: RNA granules are membraneless condensates that provide functional compartmentalization within cells. The mechanisms by which RNA granules form are under intense investigation. Here, we characterize the role of mRNAs and proteins in the formation
Harrison A. Curnutte +8 more
doaj +1 more source
Stress granule formation as a marker of cellular toxicity in lung organoids [PDF]
Organoid, 2022 Cells regulate protein synthesis under stressful circumstances by forming cytoplasmic RNA granules, termed stress granules (SGs). SGs are membrane-less organelles that function as a protective mechanism in response to stress. They function through liquid-
Seung-Yeon Kim, Kee K. Kim, Eun-Mi Kim
doaj +1 more source
Cells, 2022 Cells possess membraneless ribonucleoprotein (RNP) granules, including stress granules, processing bodies, Cajal bodies, or paraspeckles, that play physiological or pathological roles.
Pureum Jeon +3 more
doaj +1 more source
Formation of Potato Virus A-Induced RNA Granules and Viral Translation Are Interrelated Processes Required for Optimal Virus Accumulation. [PDF]
PLoS Pathogens, 2015 RNA granules are cellular structures, which play an important role in mRNA translation, storage, and degradation. Animal (+)RNA viruses often co-opt RNA granule proteins for viral reproduction.
Anders Hafrén +2 more
doaj +1 more source
Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]
, 2010 For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Tomecki, Rafał, Dziembowski, Andrzej
core +3 more sources
Aging RNA granule dynamics in neurodegeneration
Frontiers in Molecular Biosciences, 2022 Disordered RNA-binding proteins and repetitive RNA sequences are the main genetic causes of several neurodegenerative diseases, including amyotrophic lateral sclerosis and Huntington’s disease.
Kevin Rhine +13 more
doaj +1 more source
RNA supply drives physiological granule assembly in neurons
Nature Communications, 2022 RNA granules are important regulators of RNA metabolism. Here the authors report that RNA granules containing RNA helicase DDX6 disassemble during neuronal maturation.
Karl E. Bauer +6 more
doaj +1 more source
Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins
eLife, 2020 RNA granules are protein/RNA condensates. How specific mRNAs are recruited to cytoplasmic RNA granules is not known. Here, we characterize the transcriptome and assembly of P granules, RNA granules in the C. elegans germ plasm.
Chih-Yung S Lee +5 more
doaj +1 more source