Results 11 to 20 of about 125,592 (278)
Aging RNA granule dynamics in neurodegeneration
Frontiers in Molecular Biosciences, 2022 Disordered RNA-binding proteins and repetitive RNA sequences are the main genetic causes of several neurodegenerative diseases, including amyotrophic lateral sclerosis and Huntington’s disease.
Kevin Rhine +13 more
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The Journal of Cell Biology, 2006 Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress granules and processing bodies), and neurons (neuronal granules) have emerged as important players in the posttranscriptional regulation of gene expression. RNA granules contain various ribosomal subunits, translation factors, decay enzymes, helicases, scaffold ...
Anderson, Paul, Kedersha, Nancy
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RNA supply drives physiological granule assembly in neurons
Nature Communications, 2022 RNA granules are important regulators of RNA metabolism. Here the authors report that RNA granules containing RNA helicase DDX6 disassemble during neuronal maturation.
Karl E. Bauer +6 more
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RNA granules take a ride on lysosomes [PDF]
Nature Reviews Molecular Cell Biology, 2019 Efficient mRNA trafficking is supported by tethering of RNA granules to motile lysosomes through ANXA11.
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Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders [PDF]
Cell, 2013 The molecular processes that contribute to degenerative diseases are not well understood. Recent observations suggest that some degenerative diseases are promoted by the accumulation of nuclear or cytoplasmic RNA-protein (RNP) aggregates, which can be related to endogenous RNP granules. RNP aggregates arise commonly in degenerative diseases because RNA-
Ramaswami, Mani +2 more
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RNA damage compartmentalization by DHX9 stress granules
CellBiomolecules incur damage during stress conditions, and damage partitioning represents a vital survival strategy for cells. Here, we identified a distinct stress granule (SG), marked by dsRNA helicase DHX9, which compartmentalizes ultraviolet (UV)-induced RNA, but not DNA, damage.
Yilong Zhou +14 more
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RNA granules: the clock within [PDF]
Nature Reviews Molecular Cell Biology, 2013 Kim Baumann
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Enrichment of Cytoplasmic RNA Granules from Arabidopsis Seedlings. [PDF]
Bio Protoc, 2021 RNA granules (RGs) are membraneless intracellular compartments that play important roles in the post-transcriptional control of gene expression. Stress granules (SGs) are a type of RGs that form under environmental challenges and/or internal cellular stresses.
Lei Z, Kim EY, Cho J.
europepmc +4 more sources
Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila
Cell Reports, 2023 Summary: RNA granules are membraneless condensates that provide functional compartmentalization within cells. The mechanisms by which RNA granules form are under intense investigation. Here, we characterize the role of mRNAs and proteins in the formation
Harrison A. Curnutte +8 more
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Cells, 2022 Cells possess membraneless ribonucleoprotein (RNP) granules, including stress granules, processing bodies, Cajal bodies, or paraspeckles, that play physiological or pathological roles.
Pureum Jeon +3 more
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