Results 21 to 30 of about 125,592 (278)
Stress granule formation as a marker of cellular toxicity in lung organoids [PDF]
Organoid, 2022 Cells regulate protein synthesis under stressful circumstances by forming cytoplasmic RNA granules, termed stress granules (SGs). SGs are membrane-less organelles that function as a protective mechanism in response to stress. They function through liquid-
Seung-Yeon Kim, Kee K. Kim, Eun-Mi Kim
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Formation of Potato Virus A-Induced RNA Granules and Viral Translation Are Interrelated Processes Required for Optimal Virus Accumulation. [PDF]
PLoS Pathogens, 2015 RNA granules are cellular structures, which play an important role in mRNA translation, storage, and degradation. Animal (+)RNA viruses often co-opt RNA granule proteins for viral reproduction.
Anders Hafrén +2 more
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Germ Granules Govern Small RNA Inheritance [PDF]
Current Biology, 2019 In C. elegans nematodes, components of liquid-like germ granules were shown to be required for transgenerational small RNA inheritance. Surprisingly, we show here that mutants with defective germ granules can nevertheless inherit potent small RNA-based silencing responses, but some of the mutants lose this ability after many generations of homozygosity.
Itamar Lev +13 more
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The secret recipe for RNA granules [PDF]
Nature Reviews Molecular Cell Biology, 2012 openaire +3 more sources
Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins
eLife, 2020 RNA granules are protein/RNA condensates. How specific mRNAs are recruited to cytoplasmic RNA granules is not known. Here, we characterize the transcriptome and assembly of P granules, RNA granules in the C. elegans germ plasm.
Chih-Yung S Lee +5 more
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Cytoplasmic RNA Granules and Viral Infection. [PDF]
Annu Rev Virol, 2014 RNA granules are dynamic cellular structures essential for proper gene expression and homeostasis. The two principal types of cytoplasmic RNA granules are stress granules, which contain stalled translation initiation complexes, and processing bodies (P bodies), which concentrate factors involved in mRNA degradation.
Tsai WC, Lloyd RE.
europepmc +4 more sources
GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules [PDF]
Cell Metabolism, 2013 Various specialized domains have been described in the cytosol and the nucleus; however, little is known about compartmentalization within the mitochondrial matrix. GRSF1 (G-rich sequence factor 1) is an RNA binding protein that was previously reported to localize in the cytosol.
Jourdain AA +6 more
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Nuclear RNA-related processes modulate the assembly of cytoplasmic RNA granules. [PDF]
Nucleic Acids ResAbstract Stress granules (SGs) are cytoplasmic assemblies formed under various stress conditions as a consequence of translation arrest. SGs contain RNA-binding proteins, ribosomal subunits and messenger RNAs (mRNAs). It is well known that mRNAs contribute to SG formation; however, the connection between SG assembly and nuclear processes
Angel M +5 more
europepmc +3 more sources
Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB. [PDF]
Nucleic Acids Res, 2019 Hensen F +6 more
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RNA granules in germ cells. [PDF]
Cold Spring Harb Perspect Biol, 2011 "Germ granules" are cytoplasmic, nonmembrane-bound organelles unique to germline. Germ granules share components with the P bodies and stress granules of somatic cells, but also contain proteins and RNAs uniquely required for germ cell development. In this review, we focus on recent advances in our understanding of germ granule assembly, dynamics, and ...
Voronina E +3 more
europepmc +4 more sources