Results 31 to 40 of about 125,592 (278)
Mitochondrial RNA granules: Compartmentalizing mitochondrial gene expression. [PDF]
J Cell Biol, 2016 In mitochondria, DNA replication, gene expression, and RNA degradation machineries coexist within a common nondelimited space, raising the question of how functional compartmentalization of gene expression is achieved. Here, we discuss the recently characterized “mitochondrial RNA granules,” mitochondrial subdomains with an emerging role in the ...
Jourdain AA +3 more
europepmc +5 more sources
Cytoplasmic RNA Granules in Somatic Maintenance [PDF]
Gerontology, 2018 Cytoplasmic RNA granules represent subcellular compartments that are enriched in protein-bound RNA species. RNA granules are produced by evolutionary divergent eukaryotes, including yeast, mammals, and plants. The functions of cytoplasmic RNA granules differ widely. They are dictated by the cell type and physiological state, which in turn is determined
Ossama Moujaber, Ursula Stochaj
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Multiple Poliovirus Proteins Repress Cytoplasmic RNA Granules. [PDF]
Viruses, 2015 We have previously shown that poliovirus (PV) infection induces stress granule (SG) formation early in infection and then inhibits the formation of SG and disperses processing bodies (PBs) by the mid-phase of infection. Loss of SG was linked to cleavage of G3BP1 by viral 3C proteinase (3Cpro), however dispersal of PBs was not strongly linked to ...
Dougherty JD, Tsai WC, Lloyd RE.
europepmc +5 more sources
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]
, 2018 R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés +2 more
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Biology Open, 2012 Summary FMRP is an evolutionarily conserved protein that is highly expressed in neurons and its deficiency causes fragile X mental retardation syndrome.
Cristina Gareau +4 more
doaj +1 more source
The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids. [PDF]
, 2017 Trypanosomatid protozoa are unusual eukaryotes that are well known for having unusual ways of controlling their gene expression. The lack of a refined mode of transcriptional control in these organisms is compensated by several post-transcriptional ...
Campbell, David A +3 more
core +2 more sources
Frontiers in Molecular Biosciences, 2022 RNA is a vital biomolecule, the function of which is tightly spatiotemporally regulated. RNA organelles are biological structures that either membrane-less or surrounded by membrane.
Deepti Kailash Nabariya +3 more
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To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]
, 2015 Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH +2 more
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Neuronal RNA Granules: Movers and Makers [PDF]
Neuron, 2006 RNA localization contributes to cell polarity and synaptic plasticity. Evidence will be discussed that RNA transport and local translation in neurons may be more intimately linked than originally thought. Second, neuronal RNA granules, originally defined as intermediates involved in mRNA transport, are much more diverse in their composition and ...
Kiebler, Michael A., Bassell, Gary J.
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Germ Granules Allow Transmission of Small RNA-Based Parental Responses in the “Germ Plasm”
iScience, 2020 Summary: In the recent decade small RNA-based inheritance has been implicated in a variety of transmitted physiological responses to the environment. In Caenorhabditis elegans, heritable small RNAs rely on RNA-dependent RNA polymerases, RNA-processing ...
Itamar Lev, Oded Rechavi
doaj +1 more source