An Emerging Role for Post-translational Modifications in Regulating RNP Condensates in the Germ Line
Frontiers in Molecular Biosciences, 2021 RNA-binding proteins undergo regulated phase transitions in an array of cell types. The phase separation of RNA-binding proteins, and subsequent formation of RNP condensates or granules, occurs during physiological conditions and can also be induced by ...
Jennifer A. Schisa, Mohamed T. Elaswad
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An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]
, 2013 Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Darren M. Gowers (485354) +29 more
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Molecular and Cellular ProbesHuntington's disease (HD) arises from the abnormal expansion of a CAG repeat in the HTT gene. The mutant CAG repeat triggers aberrant RNA-protein interactions and translates into toxic aggregate-prone polyglutamine protein.
Deepti Kailash Nabariya +5 more
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Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]
, 2013 Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Richard M. Elliott +16 more
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Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons
Neurobiology of Disease, 2009 Fragile X syndrome is caused by lack of the protein FMRP. FMRP mediates mRNA binding, dendritic mRNA transport and translational control at spines.
Josien Levenga +7 more
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The Integral Role of RNA in Stress Granule Formation and Function
Frontiers in Cell and Developmental Biology, 2021 Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein (RNP) assemblies whose primary function is to promote cell survival by condensing translationally stalled mRNAs, ribosomal components, translation initiation factors ...
Danae Campos-Melo +5 more
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Cellular stress induces cytoplasmic RNA granules in fission yeast
, 2010 Severe stress causes plant and animal cells to form large cytoplasmic granules containing RNA and proteins. Here, we demonstrate the existence of stress-induced cytoplasmic RNA granules in Schizosaccharomyces pombe.
Nilsson, Daniel, +3 more
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Membrane recognition and dynamics of the RNA Degradosome [PDF]
, 2015 RNase E, which is the central component of the multienzyme RNA degradosome, serves as a scaffold for interaction with other enzymes involved in mRNA degradation including the DEAD-box RNA helicase RhlB.
Luisi, Ben +48 more
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Unidirectional P-body transport during the yeast cell cycle. [PDF]
PLoS ONE, 2014 P-bodies belong to a large family of RNA granules that are associated with post-transcriptional gene regulation, conserved from yeast to mammals, and influence biological processes ranging from germ cell development to neuronal plasticity.
Cecilia Garmendia-Torres +9 more
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RNA-containing cytoplasmic granules in Ythdc1-deficient oocytes.
, 2018 (A) Presence of large cytoplasmic granules in oocytes from 11-week-old Ythdc1fl/- Ddx4-Cre (cKO) females. (B) Cytoplasmic granules in oocytes from 11-week-old Ythdc1fl/- Ddx4-Cre females contain RNA.
Yang Xu (178421) +7 more
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