Results 51 to 60 of about 874,898 (240)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Complete probabilistic analysis of RNA shapes [PDF]

, 2006
Voß B, Giegerich R, Rehmsmeier M. Complete probabilistic analysis of RNA shapes. BMC Biology. 2006;4(1): 5.Background: Soon after the first algorithms for RNA folding became available, it was recognised that the prediction of only one energetically ...
Marc Rehmsmeier, Voß, Björn, Rehmsmeier, Marc, Björn Voß, Rehmsmeier Marc, Robert Giegerich, Giegerich, Robert, Giegerich Robert, Voß Björn   +8 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development [PDF]

, 2010
A universal feature of metazoan sexual development is the generation of oocyte P granules that withhold certain mRNA species from translation to provide coding potential for proteins during early post-fertilization development.
Lasonder Edwin, Franke-Fayard, Blandine M. D., Edwin Lasonder, Carret Céline K., Waters Andrew P., Lasonder, Edwin, Gunnar R Mair, Franke-Fayard Blandine M. D., Roeland W Dirks, Waters, A.P., Wiegant, J.C., Céline K Carret, Mair, G.R., Dimopoulos George, Lindsey S Garver, Mair Gunnar R., Wiegant, G., Janse, Chris J., Franke-Fayard, B.M.D., Carret, C.K., Dirks Roeland W., Mair, Gunnar R., Blandine M D Franke-Fayard, Dimopoulos, George, Wiegant, J.C.A.G., Lasonder, E., Dimopoulos, G., Janse, C.J., Joop, C.A., Wiegant, Joop C. A. G., Carret, Céline K., Waters, A., George Dimopoulos, Dirks, Roeland W., Waters, Andrew P., Garver, Lindsey S., Janse Chris J., Chris J Janse, Garver Lindsey S., Joop C A G Wiegant, Garver, L.S., Wiegant Joop C. A. G., Dirks, R.W., Franke-Fayard, B., Andrew P Waters, Garver, LS, Franke-Fayard, BMD, et al,, Mair, GR, Lasonder, E   +49 more
core   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Cell-Free Formation of RNA Granules [PDF]

, 2012
Asymmetric RNA localization is a mechanism by which a cell can spatially and temporally regulate the translation of RNAs. This mechanism is essential for many developmental processes such as germ cell formation in Drosophila embryos, as well as ...
Han, Tina Wei
core   +3 more sources

Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules.

PLoS Genetics, 2016
Local translation at the synapse plays key roles in neuron development and activity-dependent synaptic plasticity. mRNAs are translocated from the neuronal soma to the distant synapses as compacted ribonucleoparticles referred to as RNA granules.
Rachid El Fatimy, Laetitia Davidovic, Sandra Tremblay, Xavier Jaglin, Alain Dury, Claude Robert, Paul De Koninck, Edouard W Khandjian   +7 more
doaj   +1 more source

Zebrafish P54 RNA helicases are cytoplasmic granule residents that are required for development and stress resilience

Biology Open, 2016
Stress granules are cytoplasmic foci that directly respond to the protein synthesis status of the cell. Various environmental insults, such as oxidative stress or extreme heat, block protein synthesis; consequently, mRNA will stall in translation, and ...
Cecilia Zampedri, Maryana Tinoco-Cuellar, Samantha Carrillo-Rosas, Abigail Diaz-Tellez, Jose Luis Ramos-Balderas, Francisco Pelegri, Ernesto Maldonado   +6 more
doaj   +1 more source

Looking at the Pretty “Phase” of Membraneless Organelles: A View From Drosophila Glia

Frontiers in Cell and Developmental Biology, 2022
Membraneless granules assemble in different cell types and cellular loci and are the focus of intense research due to their fundamental importance for cellular organization.
Alexey L. Arkov
doaj   +1 more source

Techniques for RNA in vivo imaging in plants [PDF]

, 2015
Since the discovery of small RNAs and RNA silencing, RNA biology has taken a centre stage in cell and developmental biology. Small RNAs, but also mRNAs and other types of cellular and viral RNAs are processed at specific subcellular localizations.
Tilsner, Jens
core   +1 more source