Results 51 to 60 of about 125,592 (278)
Neurobiology of Disease, 2022 Increasing genetic and biochemical evidence has broadened our view of the pathomechanisms that lead to Spinal muscular atrophy (SMA) and Amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative diseases with similar symptoms and causes.
LiDan Hu +5 more
doaj +1 more source
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing [PDF]
, 2018 Kinetoplastid parasites—trypanosomes and leishmanias—infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies.
Barrett, Michael P. +11 more
core +3 more sources
Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease [PDF]
, 2018 Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. To study the neuron-specific function of HuR, we generated inducible, neuron-specific HuR-deficient mice of both sexes.
Bai, Ying +10 more
core +1 more source
eLife, 2016 RNA granules are non-membrane bound cellular compartments that contain RNA and RNA binding proteins. The molecular mechanisms that regulate the spatial distribution of RNA granules in cells are poorly understood. During polarization of the C.
Jarrett Smith +5 more
doaj +1 more source
Systematic Characterization of Stress-Induced RNA Granulation [PDF]
Molecular Cell, 2018 Upon stress, cytoplasmic mRNA is sequestered to insoluble ribonucleoprotein (RNP) granules, such as the stress granule (SG). Partially due to the belief that translationally suppressed mRNAs are recruited to SGs in bulk, stress-induced dynamic redistribution of mRNA has not been thoroughly characterized.
Sim, Namkoong +4 more
openaire +2 more sources
Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways [PDF]
, 2016 Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how these genetic defects lead to motor neuron degeneration and ...
Anink, Jasper J. +17 more
core +8 more sources
Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity [PDF]
, 2019 Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.
Dawson, Sally J. +6 more
core +2 more sources
Translocation of RNA Granules in Living Neurons [PDF]
The Journal of Neuroscience, 1996 Sorting of RNAs to specific subcellular loci occurs in diverse settings from fly oocytes to mammalian neurons. Using the membrane-permeable nucleic acid stain SYTO 14, we directly visualized the translocation of endogenous RNA in living cells. Labeled RNA was distributed nonrandomly as discrete granules in neuronal processes.
R B, Knowles +6 more
openaire +2 more sources
An Emerging Role for Post-translational Modifications in Regulating RNP Condensates in the Germ Line
Frontiers in Molecular Biosciences, 2021 RNA-binding proteins undergo regulated phase transitions in an array of cell types. The phase separation of RNA-binding proteins, and subsequent formation of RNP condensates or granules, occurs during physiological conditions and can also be induced by ...
Jennifer A. Schisa, Mohamed T. Elaswad
doaj +1 more source
Increasing cell density globally enhances the biogenesis of Piwi-interacting RNAs in Bombyx mori germ cells. [PDF]
, 2017 Piwi proteins and their bound Piwi-interacting RNAs (piRNAs) are predominantly expressed in the germline and play crucial roles in germline development by silencing transposons and other targets.
Honda, Shozo +7 more
core +2 more sources