Results 11 to 20 of about 19,519,160 (297)

General (p,q)-mixed projection bodies

Open Mathematics, 2020
In this article, the general (p,q)-mixed projection bodies are introduced. Then, some basic properties of the general (p,q)-mixed projection bodies are discussed, and the extreme values of volumes of the general (p,q)-mixed projection bodies and their ...
Feng Yibin, Zhou Yanping
doaj   +2 more sources

P-Bodies React to Stress and Nonsense [PDF]

Cell, 2006
P-bodies are specialized cytoplasmic compartments where translational repression and mRNA turnover may occur. Findings in this issue of Cell provide evidence that P-bodies are sites of "mRNA purgatory." Bhattacharyya et al. (2006) reveal that normal mRNA can be released from P-bodies and translated into protein in response to stress.
Bruno, Ivone, Wilkinson, Miles F.
openaire   +3 more sources

Relationship of GW/P-bodies with stress granules. [PDF]

Adv Exp Med Biol, 2013
Whereas P-bodies are intimately linked to the cytoplasmic RNA decay machinery, stress granules harbor stalled translation initiation complexes that accumulate upon stress-induced translation arrest. In this Chapter, we reflect on the relationship between P-bodies and stress granules.
Stoecklin G, Kedersha N.
europepmc   +4 more sources

RNA sequestration in P-bodies sustains myeloid leukaemia. [PDF]

Nat Cell Biol
Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through genome-wide CRISPR screens in normal and malignant haematopoietic progenitors.
Kodali S, Proietti L, Valcarcel G, López-Rubio AV, Pessina P, Eder T, Shi J, Jen A, Lupión-Garcia N, Starner AC, Bartels MD, Cui Y, Sands CM, Planas-Riverola A, Martínez A, Velasco-Hernandez T, Tomás-Daza L, Alber B, Manhart G, Mayer IM, Kollmann K, Fatica A, Menendez P, Shishkova E, Rau RE, Javierre BM, Coon J, Chen Q, Van Nostrand EL, Sardina JL, Grebien F, Di Stefano B.   +31 more
europepmc   +5 more sources

Prolonged Pseudohypoxia Targets Ambra1 mRNA to P-Bodies for Translational Repression. [PDF]

PLoS ONE, 2015
Hypoxia has been associated with several pathological conditions ranging from stroke to cancer. This condition results in the activation of autophagy, a cyto-protective response involving the formation of double-membraned structures, the autophagosomes ...
Somayeh Pourpirali, Cristina Valacca, Paola Merlo, Salvatore Rizza, Silvia D'Amico, Francesco Cecconi   +5 more
doaj   +2 more sources

A rapid inducible RNA decay system reveals fast mRNA decay in P-bodies [PDF]

Nature Communications
RNA decay is vital for regulating mRNA abundance and gene expression. Existing technologies lack the spatiotemporal precision or transcript specificity to capture the stochastic and transient decay process.
Lauren A. Blake, Leslie Watkins, Yang Liu, Takanari Inoue, Bin Wu   +4 more
doaj   +2 more sources

P439: RNA SEQUESTRATION IN P-BODIES PROMOTES LEUKEMIA ONSET AND PROGRESSION [PDF]

HemaSphere, 2023
Ludovica Proietti, Srikanth Kodali, Gemma Valcarcel, Anna Vanessa Lopez-Rubio, Patrizia Pessina, Thomas Eder, Yingzhi Cui, Florencia Levin, Bernhard Alber, Gabriele Manhart, Alessandro Fatica, Jose Louis Sardina, Bruno DI Stefano, Florian Grebien   +13 more
doaj   +2 more sources

Condensation properties of stress granules and processing bodies are compromised in myotonic dystrophy type 1

Disease Models & Mechanisms, 2022
RNA regulation in mammalian cells requires complex physical compartmentalisation, using structures thought to be formed by liquid-liquid phase separation. Disruption of these structures is implicated in numerous degenerative diseases.
Selma Gulyurtlu, Monika S. Magon, Patrick Guest, Panagiotis P. Papavasiliou, Kim D. Morrison, Alan R. Prescott, Judith E. Sleeman   +6 more
doaj   +1 more source

Phytochrome A Mediates the Disassembly of Processing Bodies in Far-Red Light

Frontiers in Plant Science, 2022
Phytochromes are red- and far-red light receptors that control the growth and development of plants, enabling them to respond adequately to changing light conditions. It has been shown that halted mRNAs stored in RNA granules called processing bodies are
Philipp Schwenk, Philipp Schwenk, Andreas Hiltbrunner, Andreas Hiltbrunner   +3 more
doaj   +1 more source

Regulation of Cellular Ribonucleoprotein Granules: From Assembly to Degradation via Post-translational Modification

Cells, 2022
Cells possess membraneless ribonucleoprotein (RNP) granules, including stress granules, processing bodies, Cajal bodies, or paraspeckles, that play physiological or pathological roles.
Pureum Jeon, Hyun-Ji Ham, Semin Park, Jin-A Lee   +3 more
doaj   +1 more source