Results 11 to 20 of about 645,423 (346)
Combined modelling of mRNA decay dynamics and single-molecule imaging in the Drosophila embryo uncovers a role for P-bodies in 5' to 3' degradation. [PDF]
PLoS Biol, 2023 Forbes Beadle L +5 more
europepmc +2 more sources
Disease Models & Mechanisms, 2022 RNA regulation in mammalian cells requires complex physical compartmentalisation, using structures thought to be formed by liquid-liquid phase separation. Disruption of these structures is implicated in numerous degenerative diseases.
Selma Gulyurtlu +6 more
doaj +1 more source
Phytochrome A Mediates the Disassembly of Processing Bodies in Far-Red Light
Frontiers in Plant Science, 2022 Phytochromes are red- and far-red light receptors that control the growth and development of plants, enabling them to respond adequately to changing light conditions. It has been shown that halted mRNAs stored in RNA granules called processing bodies are
Philipp Schwenk +3 more
doaj +1 more source
P-Bodies: Composition, Properties, and Functions. [PDF]
Biochemistry, 2018 Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid droplets.
Luo Y, Na Z, Slavoff SA.
europepmc +4 more sources
Deadenylation and P-bodies. [PDF]
Adv Exp Med Biol, 2013 Deadenylation is the major step in triggering mRNA decay and results in mRNA translation inhibition in eukaryotic cells. Therefore, it is plausible that deadenylation also induces the mRNP remodeling required for formation of GW bodies or RNA processing bodies (P-bodies), which harbor translationally silenced mRNPs.
Chen CY, Shyu AB.
europepmc +4 more sources
Cells, 2022 Cells possess membraneless ribonucleoprotein (RNP) granules, including stress granules, processing bodies, Cajal bodies, or paraspeckles, that play physiological or pathological roles.
Pureum Jeon +3 more
doaj +1 more source
Stress granules, P-bodies and cancer. [PDF]
Biochim Biophys Acta, 2015 Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize post-transcriptional control mechanisms to re-program gene expression in ways that enhance cell survival. Stress granules and processing bodies are RNA-containing granules that contribute to this process by modulating cellular signaling pathways, metabolic ...
Anderson P, Kedersha N, Ivanov P.
europepmc +4 more sources
Microtubule disruption stimulates P-body formation [PDF]
RNA, 2007 Processing bodies (P-bodies) are subcellular ribonucleoprotein (RNP) granules that have been hypothesized to be sites of mRNA degradation, mRNA translational control, and/or mRNA storage. Importantly, P-bodies are conserved from yeast to mammals and contain a common set of evolutionarily conserved protein constituents.
Thomas J, Sweet +4 more
openaire +2 more sources
RNA Granules: A View from the RNA Perspective
Molecules, 2020 RNA granules are ubiquitous. Composed of RNA-binding proteins and RNAs, they provide functional compartmentalization within cells. They are inextricably linked with RNA biology and as such are often referred to as the hubs for post-transcriptional ...
Siran Tian +2 more
doaj +1 more source