Results 31 to 40 of about 27,859 (170)

Putative SF2 helicases of the early-branching eukaryote Giardia lamblia are involved in antigenic variation and parasite differentiation into cysts

BMC Microbiology, 2012
Background Regulation of surface antigenic variation in Giardia lamblia is controlled post-transcriptionally by an RNA-interference (RNAi) pathway that includes a Dicer-like bidentate RNase III (gDicer).
Gargantini Pablo R, Serradell Marianela C, Torri Alessandro, Lujan Hugo D   +3 more
doaj   +1 more source

The role of RNA helicases in aging and lifespan regulation

Translational Medicine of Aging, 2017
RNA helicases are members of a large family of enzymes that function in unwinding RNA duplexes and modulating interactions between RNAs and proteins. RNA helicases participate in numerous cellular processes, including transcription, translation, mRNA ...
Sangsoon Park, Hae-Eun H. Park, Heehwa G. Son, Seung-Jae V. Lee   +3 more
doaj   +1 more source

psiCLIP reveals dynamic RNA binding by DEAH-box helicases before and after exon ligation

Nature Communications, 2021
ATP-dependent helicases remodel the spliceosome and proofread splice site recognition. A new method – Purified Spliceosome iCLIP (psiCLIP) – probes protein-RNA interactions in defined spliceosome complexes to reveal how the helicases Prp16 and Prp22 ...
Lisa M. Strittmatter, Charlotte Capitanchik, Andrew J. Newman, Martina Hallegger, Christine M. Norman, Sebastian M. Fica, Chris Oubridge, Nicholas M. Luscombe, Jernej Ule, Kiyoshi Nagai   +9 more
doaj   +1 more source

The emerging role of DEAD/H-box helicases in hepatitis B virus infection

Frontiers in Cellular and Infection Microbiology, 2022
DEAD/H-box helicases are an essential protein family with a conserved motif containing unique amino acid sequences (Asp-Glu-Ala-Asp/His). Current evidence indicates that DEAD/H-box helicases regulate RNA metabolism and innate immune responses.
Hongjuan You, Lihong Ma, Xing Wang, Fulong Zhang, Yiran Han, Jiaqi Yao, Xiucheng Pan, Kuiyang Zheng, Kuiyang Zheng, Fanyun Kong, Renxian Tang, Renxian Tang   +11 more
doaj   +1 more source

Structural Basis of DEAH/RHA Helicase Activity

Crystals, 2017
DEAH/RHA helicases are members of a large group of proteins collectively termed DExH-box, which also include Ski2-like and NS3/NPH-II helicases. By binding and remodeling DNA and RNA, DEAH/RHA helicases play critical roles in many cellular processes ...
Michael C. Chen, Adrian R. Ferré-D’Amaré   +1 more
doaj   +1 more source

Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy

Frontiers in Oncology, 2023
DEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including transcription, pre-mRNA splicing, ribosomes biogenesis, nuclear export, translation initiation, RNA degradation, and mRNA editing.
Ananna Bhadra Arna, Hardikkumar Patel, Ravi Shankar Singh, Frederick S. Vizeacoumar, Anthony Kusalik, Andrew Freywald, Franco J. Vizeacoumar, Yuliang Wu   +7 more
doaj   +1 more source

Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer

Frontiers in Oncology, 2023
Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately, this disease is changing rapidly to a younger age, and in a more advanced stage
Bichun Zheng, Xudong Chen, Qiaoyun Ling, Quan Cheng, Shaoshun Ye   +4 more
doaj   +1 more source

From promoting to inhibiting: diverse roles of helicases in HIV-1 Replication

Retrovirology, 2012
Helicases hydrolyze nucleotide triphosphates (NTPs) and use the energy to modify the structures of nucleic acids. They are key players in every cellular process involving RNA or DNA. Human immunodeficiency virus type 1 (HIV-1) does not encode a helicase,
Lorgeoux Rene-Pierre, Guo Fei, Liang Chen   +2 more
doaj   +1 more source

High Levels of DEAH-Box Helicases Relate to Poor Prognosis and Reduction of DHX9 Improves Radiosensitivity of Hepatocellular Carcinoma

Frontiers in Oncology, 2022
BackgroundLiver hepatocellular carcinoma (LIHC), one of the most common primary malignancies, exhibits high levels of molecular and clinical heterogeneity.
Xi Chen, Xi Chen, Xi Chen, Letao Lin, Letao Lin, Letao Lin, Guanyu Chen, Guanyu Chen, Guanyu Chen, Huzheng Yan, Zhenyu Li, Zhenyu Li, Meigui Xiao, Meigui Xiao, Meigui Xiao, Xu He, Fujun Zhang, Fujun Zhang, Fujun Zhang, Yanling Zhang, Yanling Zhang, Yanling Zhang, Yanling Zhang   +22 more
doaj   +1 more source

The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans

Frontiers in Molecular Biosciences, 2021
G-quadruplexes (G4s) are stable non-canonical secondary structures formed by G-rich DNA or RNA sequences. They play various regulatory roles in many biological processes.
Yang Liu, Yang Liu, Yang Liu, Yang Liu, Xinting Zhu, Kejia Wang, Kejia Wang, Kejia Wang, Bo Zhang, Shuyi Qiu, Shuyi Qiu, Shuyi Qiu   +11 more
doaj   +1 more source