Results 51 to 60 of about 1,270,992 (292)

Dna2 Helicase/Nuclease Causes Replicative Fork Stalling and Double-strand Breaks in the Ribosomal DNA of Saccharomyces cerevisiae [PDF]

, 2003
We have proposed that faulty processing of arrested replication forks leads to increases in recombination and chromosome instability in Saccharomyces cerevisiae and contributes to the shortened lifespan of dna2 mutants. Now we use the ribosomal DNA locus,
Budd, Martin, Campbell, Judith L., Mays Hoopes, Laura L., Weitao, Tao   +3 more
core   +2 more sources

DNA repair: Disorders [PDF]

, 2010
No description ...
Bose, Burg, Caldecott, Chu, Digweed, Fernandez-Capetillo, Fousteri, Fousteri, Friedberg, Gudmundsdottir, Hashimoto, Hoeijmakers, Jiricny, Kraemer, Lavin, Lehmann, Lieber, Ma, Masutani, McCulloch, Meindl, Moldovan, Moshous, Nance, Nouspikel, O'Driscoll, O'Driscoll, O'Driscoll, O'Driscoll, Rass, Stefanini, Stewart, Stracker, Taylor, Vaz, Wu, Zlatanou   +36 more
core   +1 more source

The emerging role of DEAD/H-box helicases in hepatitis B virus infection

Frontiers in Cellular and Infection Microbiology, 2022
DEAD/H-box helicases are an essential protein family with a conserved motif containing unique amino acid sequences (Asp-Glu-Ala-Asp/His). Current evidence indicates that DEAD/H-box helicases regulate RNA metabolism and innate immune responses.
Hongjuan You, Lihong Ma, Xing Wang, Fulong Zhang, Yiran Han, Jiaqi Yao, Xiucheng Pan, Kuiyang Zheng, Kuiyang Zheng, Fanyun Kong, Renxian Tang, Renxian Tang   +11 more
doaj   +1 more source

Machines on Genes: Enzymes that Make, Break and Move DNA and RNA [PDF]

, 2010
As the vital information repositories of the cell, the nucleic acids DNA and RNA pose many challenges as enzyme substrates. To produce, maintain and repair DNA and RNA, and to extract the genetic information that they encode, a battery of remarkable ...
Bates, Belousoff, Ben F. Luisi, Lilley, Marshall, Olorunniji, Rice, Richard P. Bowater, Sherratt, Smith, Szczelkun, Tomlinson, W. Marshall Stark, Weinzierl   +13 more
core   +1 more source

Structural Basis of DEAH/RHA Helicase Activity

Crystals, 2017
DEAH/RHA helicases are members of a large group of proteins collectively termed DExH-box, which also include Ski2-like and NS3/NPH-II helicases. By binding and remodeling DNA and RNA, DEAH/RHA helicases play critical roles in many cellular processes ...
Michael C. Chen, Adrian R. Ferré-D’Amaré   +1 more
doaj   +1 more source

Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy

Frontiers in Oncology, 2023
DEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including transcription, pre-mRNA splicing, ribosomes biogenesis, nuclear export, translation initiation, RNA degradation, and mRNA editing.
Ananna Bhadra Arna, Hardikkumar Patel, Ravi Shankar Singh, Frederick S. Vizeacoumar, Anthony Kusalik, Andrew Freywald, Franco J. Vizeacoumar, Yuliang Wu   +7 more
doaj   +1 more source

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

bioRxiv, 2020
RNA helicases and ubiquitin E3 ligases mediate many critical functions within cells, but their actions have been studied largely in distinct biological contexts.
Kazuki Kato, Sadeem Ahmad, Zixiang Zhu, Janet M. Young, X. Mu, Sehoon Park, Harmit S. Malik, S. Hur   +7 more
semanticscholar   +1 more source

Use of streptavidin bound to biotinylated DNA structures as model substrates for analysis of nucleoprotein complex disruption by helicases [PDF]

, 2016
Helicases are a subfamily of translocases that couple the directional translocation along a nucleic acid lattice to the separation of nucleic acid duplexes using the energy derived from nucleoside triphosphate hydrolysis.
Brüning, Jan-Gert, Howard, Jamieson A L, McGlynn, Peter   +2 more
core   +1 more source

RNA helicase and colon cancer [PDF]

Cancer Biology & Therapy, 2008
Commentary to:Knockdown of RCK/p54 expression by RNAi inhibits proliferation of human colorectal cancer cells in vitro and in vivo Fang Lin, Rui Wang, Jian-Jun Shen, Xi Wang, Ping Gao, Ke Dong, Hui-Zhong ...
Jun, Zhang, Hwan Ki, Park, Haijing, Sun, Peiwen, Fei   +3 more
openaire   +2 more sources

RNA Helicase A Regulates the Replication of RNA Viruses [PDF]

Viruses, 2021
The RNA helicase A (RHA) is a member of DExH-box helicases and characterized by two double-stranded RNA binding domains at the N-terminus. RHA unwinds double-stranded RNA in vitro and is involved in RNA metabolisms in the cell. RHA is also hijacked by a variety of RNA viruses to facilitate virus replication. Herein, this review will provide an overview
Rui-Zhu Shi, Yuan-Qing Pan, Li Xing
openaire   +3 more sources