Results 51 to 60 of about 768,185 (263)

Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer

Frontiers in Oncology, 2023
Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately, this disease is changing rapidly to a younger age, and in a more advanced stage
Bichun Zheng, Xudong Chen, Qiaoyun Ling, Quan Cheng, Shaoshun Ye   +4 more
doaj   +1 more source

From promoting to inhibiting: diverse roles of helicases in HIV-1 Replication

Retrovirology, 2012
Helicases hydrolyze nucleotide triphosphates (NTPs) and use the energy to modify the structures of nucleic acids. They are key players in every cellular process involving RNA or DNA. Human immunodeficiency virus type 1 (HIV-1) does not encode a helicase,
Lorgeoux Rene-Pierre, Guo Fei, Liang Chen   +2 more
doaj   +1 more source

The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans

Frontiers in Molecular Biosciences, 2021
G-quadruplexes (G4s) are stable non-canonical secondary structures formed by G-rich DNA or RNA sequences. They play various regulatory roles in many biological processes.
Yang Liu, Yang Liu, Yang Liu, Yang Liu, Xinting Zhu, Kejia Wang, Kejia Wang, Kejia Wang, Bo Zhang, Shuyi Qiu, Shuyi Qiu, Shuyi Qiu   +11 more
doaj   +1 more source

Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication [PDF]

, 2010
© The Author(s) 2010. Published by Oxford University PressGenome duplication requires accessory helicases to displace proteins ahead of advancing replication forks.
Lloyd, RG, McGlynn, P, Hazel Bell, Robert G. Lloyd, John Atkinson, Peter McGlynn, Atkinson, J, Bell, H, Christian J. Rudolph, Gupta, MK, Rudolph, CJ, Milind K. Gupta   +11 more
core   +1 more source

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation. [PDF]

, 2010
RecQ helicases have attracted considerable interest in recent years due to their role in the suppression of genome instability and human diseases. These atypical helicases exert their function by resolving a number of highly specific DNA structures.
M. Berti, C. D. O. Cooper, Y. Zhang, Gileadi, Opher, Niesen, Frank H., O. King, Berti, M, Gileadi, O, A. C. W. Pike, Berti, Matteo, Vindigni, Alessandro, N. A. Burgess-Brown, Pike, AC, F. H. Niesen, King, O, Niesen, FH, A. Vindigni, Cooper, CD, R. Mendoza-Maldonado, King, Oliver, Burgess-Brown, Nicola, Mendoza-Maldonado, R, Vindigni, A, Zhang, Y, B. Lucic, Lucic, B, O. Gileadi, Burgess-Brown, NA, Pike, Ashley C.W., Lucic, Bojana, Zhang, Ying, Burgess-Brown, Nicola A., Mendoza-Maldonado, Ramiro, Cooper, Christopher D.O.   +33 more
core   +1 more source

Redox-Regulated RNA Helicase Expression [PDF]

Plant Physiology, 2000
Abstract In photosynthetic organisms it is becoming increasingly evident that light-driven shifts in redox potential act as a sensor that initiates alterations in gene expression at both the level of transcription and translation. This report provides evidence that the expression of a cyanobacterial RNA helicase gene,crhR, is controlled ...
Kujat, S. L., Owttrim, G. W.
openaire   +3 more sources

High Levels of DEAH-Box Helicases Relate to Poor Prognosis and Reduction of DHX9 Improves Radiosensitivity of Hepatocellular Carcinoma

Frontiers in Oncology, 2022
BackgroundLiver hepatocellular carcinoma (LIHC), one of the most common primary malignancies, exhibits high levels of molecular and clinical heterogeneity.
Xi Chen, Xi Chen, Xi Chen, Letao Lin, Letao Lin, Letao Lin, Guanyu Chen, Guanyu Chen, Guanyu Chen, Huzheng Yan, Zhenyu Li, Zhenyu Li, Meigui Xiao, Meigui Xiao, Meigui Xiao, Xu He, Fujun Zhang, Fujun Zhang, Fujun Zhang, Yanling Zhang, Yanling Zhang, Yanling Zhang, Yanling Zhang   +22 more
doaj   +1 more source

Unwinding and Rewinding: Double Faces of Helicase?

Journal of Nucleic Acids, 2012
Helicases are enzymes that use ATP-driven motor force to unwind double-stranded DNA or RNA. Recently, increasing evidence demonstrates that some helicases also possess rewinding activity—in other words, they can anneal two complementary single-stranded ...
Yuliang Wu
doaj   +1 more source

Molecular functions of RNA helicases during ribosomal subunit assembly [PDF]

, 2023
During their biogenesis, the ribosomal subunits undergo numerous structural and compositional changes to achieve their final architecture. RNA helicases are a key driving force of such remodelling events but deciphering their particular functions has ...
Khreiss, A., Bohnsack, M., Ali Khreiss, Markus T. Bohnsack, Khreiss, Ali, Bohnsack, Markus T., Bohnsack, Katherine E., Bohnsack, K., Katherine E. Bohnsack   +8 more
core   +1 more source

Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction [PDF]

, 2012
This work was supported by the Wellcome Trust (grant AL087751/B)RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD ...
Childs, Kay, Randall, Richard, Goodbourn, Stephen   +2 more
core   +2 more sources