Results 71 to 80 of about 1,270,992 (292)

Mtr4 RNA helicase structures and interactions

Biological Chemistry, 2021
Abstract Mtr4 is a Ski2-like RNA helicase that plays a central role in RNA surveillance and degradation pathways as an activator of the RNA exosome. Multiple crystallographic and cryo-EM studies over the past 10 years have revealed important insight into the Mtr4 structure and interactions with protein and nucleic acid binding partners ...
Keith J. Olsen, Sean J. Johnson
openaire   +3 more sources

The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans

Frontiers in Molecular Biosciences, 2021
G-quadruplexes (G4s) are stable non-canonical secondary structures formed by G-rich DNA or RNA sequences. They play various regulatory roles in many biological processes.
Yang Liu, Yang Liu, Yang Liu, Yang Liu, Xinting Zhu, Kejia Wang, Kejia Wang, Kejia Wang, Bo Zhang, Shuyi Qiu, Shuyi Qiu, Shuyi Qiu   +11 more
doaj   +1 more source

Structural visualization of key steps in human transcription initiation. [PDF]

, 2013
Eukaryotic transcription initiation requires the assembly of general transcription factors into a pre-initiation complex that ensures the accurate loading of RNA polymerase II (Pol II) at the transcription start site. The molecular mechanism and function
Fang, Jie, He, Yuan, NOGALES, Eva, Taatjes, Dylan   +3 more
core   +1 more source

Unwinding and Rewinding: Double Faces of Helicase?

Journal of Nucleic Acids, 2012
Helicases are enzymes that use ATP-driven motor force to unwind double-stranded DNA or RNA. Recently, increasing evidence demonstrates that some helicases also possess rewinding activity—in other words, they can anneal two complementary single-stranded ...
Yuliang Wu
doaj   +1 more source

A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication [PDF]

, 2011
DEAD-box proteins are enzymes endowed with nucleic acid-dependent ATPase, RNA translocase and unwinding activities. The human DEAD-box protein DDX3 has been shown to play important roles in tumor proliferation and viral infections.
Garbelli, Anna, Beermann, Sandra, Di Cicco, Giulia, Dietrich, Ursula, Maga, Giovanni   +4 more
core   +1 more source

Collective effects in intra-cellular molecular motor transport: coordination, cooperation and competetion [PDF]

, 2006
Molecular motors do not work in isolation {\it in-vivo}. We highlight some of the coordinations, cooperations and competitions that determine the collective properties of molecular motors in eukaryotic cells.
Chowdhury, Debashish
core   +2 more sources

Targeting R-loops: diverse RNA helicases in R-loop resolution and their potential as targets for cancer therapy

Frontiers in Cell and Developmental Biology
RNA helicases are enzymes that remodel RNA secondary structures and RNA-protein complexes using ATP-driven motor forces. They are known to participate in many essential cellular processes, including transcription, splicing, translation, RNA decay, and ...
Katherine Herrera, Kaoru Takasaki, Kaoru Takasaki, Takahiko Murayama   +3 more
doaj   +1 more source

Role reversal of functional identity in host factors: Dissecting features affecting pro-viral versus antiviral functions of cellular DEAD-box helicases in tombusvirus replication.

PLoS Pathogens, 2020
Positive-stranded (+)RNA viruses greatly exploit host cells to support viral replication. However, unlike many other pathogens, (+)RNA viruses code for only a limited number of genes, making them highly dependent on numerous co-opted host factors for ...
Cheng-Yu Wu, Peter D Nagy
doaj   +1 more source

Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity

mBio, 2021
Innate immunity serves as the first barrier against virus infection. DEAD (Glu-Asp-Ala-Glu) box RNA helicases, originally considered to be involved in RNA processing and RNA unwinding, have been shown to play an important role in antiviral innate ...
Wei Wu, Yang Qu, Shengqing Yu, Sa Wang, Yuncong Yin, Qinfang Liu, Chunchun Meng, Ying Liao, Zaib Ur Rehman, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Chan Ding, Yingjie Sun   +14 more
doaj   +1 more source

RNA turnover: The helicase story unwinds [PDF]

Current Biology, 1996
AbstractRecent results show that RNA helicases play important roles in RNA decay, both as exoribonuclease accessory factors and in communicating signals to RNA decay machinery.
Jacobs Anderson, John S, Parker, Roy
openaire   +2 more sources