Comparative structural analysis of human DEAD-box RNA helicases. [PDF]
PLoS ONE, 2010 DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections.
Patrick Schütz +12 more
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Selective pharmacological targeting of a DEAD box RNA helicase. [PDF]
PLoS ONE, 2008 RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected
Lisa Lindqvist +11 more
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Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies [PDF]
Genes and DiseasesHematopoiesis represents a meticulously regulated and dynamic biological process. Genetic aberrations affecting blood cells, induced by various factors, frequently give rise to hematological tumors. These instances are often accompanied by a multitude of
Jiankun Fan, Zhigang Li, Li Pei, Yu Hou
doaj +4 more sources
DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy [PDF]
Cells, 2021 Cell cycle is regulated through numerous signaling pathways that determine whether cells will proliferate, remain quiescent, arrest, or undergo apoptosis. Abnormal cell cycle regulation has been linked to many diseases.
Lu Zhang, Xiaogang Li
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Coupling between the DEAD-box RNA helicases Ded1p and eIF4A [PDF]
eLife, 2016 Eukaryotic translation initiation involves two conserved DEAD-box RNA helicases, eIF4A and Ded1p. Here we show that S. cerevisiae eIF4A and Ded1p directly interact with each other and simultaneously with the scaffolding protein eIF4G.
Zhaofeng Gao +7 more
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DEAD-box RNA helicases with special reference to p68: Unwinding their biology, versatility, and therapeutic opportunity in cancer [PDF]
Genes and Diseases, 2023 In the era of advancement, the entire world continues to remain baffled by the increased rate of progression of cancer. There has been an unending search for novel therapeutic targets and prognostic markers to curb the oncogenic scenario.
Shaheda Tabassum, Mrinal K. Ghosh
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Role of DEAD-box RNA helicases in low-temperature adapted growth of Antarctic Pseudomonas syringae Lz4W [PDF]
Microbiology SpectrumPseudomonas syringae possesses genes for all five major DEAD-box RNA helicases, rhlE, srmB, csdA, dbpA, and rhlB, that are found in γ-proteobacteria.
Ashaq Hussain, Malay Kumar Ray
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A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. [PDF]
Mol Biol Cell, 2017 Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation.
Jao LE, Akef A, Wente SR.
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Chloroplast- or Mitochondria-Targeted DEAD-Box RNA Helicases Play Essential Roles in Organellar RNA Metabolism and Abiotic Stress Responses [PDF]
Frontiers in Plant Science, 2017 The yields and productivity of crops are greatly diminished by various abiotic stresses, including drought, cold, heat, and high salinity. Chloroplasts and mitochondria are cellular organelles that can sense diverse environmental stimuli and alter gene ...
Ghazala Nawaz, Hunseung Kang
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Caspase-mediated DDX46 cleavage unchains antiviral immunity [PDF]
mBioDEAD/H-box RNA helicases are critical regulators of host antiviral innate immunity. In this study, we utilized an RNA-binding protein knockout sub-library to identify DDX46, a member of the DEAD/H-box RNA helicase family, as an essential proviral host ...
Yanfeng Liu +11 more
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