Selective pharmacological targeting of a DEAD box RNA helicase. [PDF]
PLoS ONE, 2008 RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected
Lisa Lindqvist +11 more
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DEAD-box helicase proteins disrupt RNA tertiary structure through helix capture. [PDF]
PLoS Biology, 2014 DEAD-box helicase proteins accelerate folding and rearrangements of highly structured RNAs and RNA-protein complexes (RNPs) in many essential cellular processes. Although DEAD-box proteins have been shown to use ATP to unwind short RNA helices, it is not
Cynthia Pan +6 more
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Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer [PDF]
Frontiers in Oncology, 2023 Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately, this disease is changing rapidly to a younger age, and in a more advanced stage
Bichun Zheng +4 more
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The advances of DEAD-box RNA helicase 17 in chronic non-infectious diseases [PDF]
Frontiers in Cardiovascular MedicineDEAD-box RNA helicase 17 (DDX17), a key member of the DEAD-box family, is vital in cellular physiological processes. This review summarizes its structural properties, distribution, functions, disease associations, and research trends. Structurally, DDX17
Mi Xiong +8 more
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The DEAD-box RNA helicase RhlB is required for efficient RNA processing at low temperature in Caulobacter [PDF]
Microbiology Spectrum, 2023 The RNA helicases from the DEAD-box family participate in several biochemical processes, with special relevance in the assembly of ribosome ribonucleoparticles and in RNA turnover as part of the multi-enzymatic RNA degradosome complex.
Hugo L. de Araújo +8 more
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Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates [PDF]
Scientific Reports, 2023 Inhibition of eukaryotic initiation factor 4A has been proposed as a strategy to fight pathogens. Rocaglates exhibit the highest specificities among eIF4A inhibitors, but their anti-pathogenic potential has not been comprehensively assessed across ...
Wiebke Obermann +22 more
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Genome-Wide Analysis of DEAD-box RNA Helicase Family in Wheat (Triticum aestivum) and Functional Identification of TaDEAD-box57 in Abiotic Stress Responses [PDF]
Frontiers in Plant Science, 2021 DEAD-box RNA helicases constitute the largest subfamily of RNA helicase superfamily 2 (SF2), and play crucial roles in plant growth, development, and abiotic stress responses.
Jing-Na Ru +11 more
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DEAD-box RNA helicase 21 negatively regulates cytosolic RNA-mediated innate immune signaling [PDF]
Frontiers in Immunology, 2022 DEAD-box RNA helicase 21 (DDX21), also known as RHII/Gu, is an ATP-dependent RNA helicase. In addition to playing a vital role in regulating cellular RNA splicing, transcription, and translation, accumulated evidence has suggested that DDX21 is also ...
Jia Li +11 more
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DDX5 facilitates HIV-1 replication as a cellular co-factor of Rev. [PDF]
PLoS ONE, 2013 HIV-1 Rev plays an important role in the late phase of HIV-1 replication, which facilitates export of unspliced viral mRNAs from the nucleus to cytoplasm in infected cells. Recent studies have shown that DDX1 and DDX3 are co-factors of Rev for the export
Xiuxia Zhou +9 more
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Journal of Plant Interactions, 2022 The DEAD-box family has been shown to play an important role in a variety of abiotic stresses, but little is known in studies of mangrove plants. Here, the effects of cold stress on various physiological changes and the role of the DEAD-box RNA helicase ...
LuLu Hao +6 more
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