Results 1 to 10 of about 17,003 (153)
mBio, 2018 Present in every kingdom of life, generally in multiple copies, DEAD-box RNA helicases are specialized enzymes that unwind RNA secondary structures. They play major roles in mRNA decay, ribosome biogenesis, and adaptation to cold temperatures.
Lamya El Mortaji +7 more
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Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy
Frontiers in Oncology, 2023 DEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including transcription, pre-mRNA splicing, ribosomes biogenesis, nuclear export, translation initiation, RNA degradation, and mRNA editing.
Ananna Bhadra Arna +7 more
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Heterogeneous dissociation process of truncated RNAs by oligomerized Vasa helicase
Communications Biology, 2021 Kinoshita et al. use single molecule imaging to show that the N-terminal extension of BmVasa, a germ-specific DEAD box RNA helicase, is necessary for protein oligomerization and the dissociation of target RNA from the Siwi-piRISC complex.
Yoshimi Kinoshita +5 more
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eLife, 2014 How different helicase families with a conserved catalytic ‘helicase core’ evolved to function on varied RNA and DNA substrates by diverse mechanisms remains unclear.
Anna L Mallam +2 more
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RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis
Cell Reports, 2019 Summary: DDX17, a DEAD-box ATPase, is a multifunctional helicase important for various RNA functions, including microRNA maturation. Key questions for DDX17 include how it recognizes target RNAs and influences their structures, as well as how its ATPase ...
Tri D. Ngo +2 more
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Frontiers in Oncology, 2021 Ovarian carcinoma remains the most lethal gynecological carcinoma. Abnormal expression of splicing factors is closely related to the occurrence and development of tumors.
Chen Zhao +17 more
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The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription. [PDF]
PLoS ONE, 2016 RNA helicase family members exhibit diverse cellular functions, including in transcription, pre-mRNA processing, RNA decay, ribosome biogenesis, RNA export and translation.
Nian Xiang +10 more
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Selective pharmacological targeting of a DEAD box RNA helicase.
PLoS ONE, 2008 RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected
Lisa Lindqvist +11 more
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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
Molecular & Cellular Oncology, 2021 In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair ...
Belen Gómez-González +3 more
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RNA Helicase Mediates Competitive Fitness of Listeria monocytogenes on the Surface of Cantaloupe
Horticulturae, 2018 Listeria monocytogenes is a foodborne pathogen that is implicated in numerous outbreaks of disease (listeriosis) via fresh produce. The genetic features of L. monocytogenes that allow adherence and growth on produce remain largely uncharacterized.
Robert Price +2 more
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