Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12
Brazilian Journal of Medical and Biological Research, 2001 DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension
A.A. Camargo +6 more
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A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication [PDF]
, 2011 DEAD-box proteins are enzymes endowed with nucleic acid-dependent ATPase, RNA translocase and unwinding activities. The human DEAD-box protein DDX3 has been shown to play important roles in tumor proliferation and viral infections.
Di Cicco, Giulia +9 more
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Investigation of the guanine quadruplex resolving activity of the DEAH-box RNA helicase RHAU [PDF]
, 2012 Generally depicted as single- or double-stranded molecules, nucleic acids sequences can adopt various forms of stable secondary structures. In particular, guanine-riche sequence of DNA and RNA can form atypical four-stranded helical structures termed G ...
Lattmann, Simon
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Coordinated function of cellular DEAD-box helicases in suppression of viral RNA recombination and maintenance of viral genome integrity. [PDF]
PLoS Pathogens, 2015 The intricate interactions between viruses and hosts include an evolutionary arms race and adaptation that is facilitated by the ability of RNA viruses to evolve rapidly due to high frequency mutations and genetic RNA recombination.
Chingkai Chuang +2 more
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Xp54 and related (DDX6-like) RNA helicases : roles in messenger RNP assembly, translation regulation and RNA degradation [PDF]
, 2006 The DEAD-box RNA helicase Xp54 is an integral component of the messenger ribonucleoprotein (mRNP) particles of Xenopus oocytes. In oocytes, several abundant proteins bind pre-mRNA transcripts to modulate nuclear export, RNA stability and translational ...
Weston, A, Sommerville, John
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Biological roles of DExH RNA helicase, RHAU [PDF]
, 2007 In this thesis, I have described the work carried out on a single protein called RHAU, dealing with aspects of protein localization in cells, the regulation of global gene expression by different mechanisms, and cellular stress-responses.
Iwamoto, Fumiko
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Die DEAD-box Helikase Hera aus "Thermus thermophilus". Untersuchung der Wechselwirkung mit Nukleinsäuren und der Helikaseaktivität [PDF]
, 2009 Hera ist eine DEAD-Box Helikase aus Thermus thermophilus. Wie bei vielen anderen DEADbox Helikasen auch, ist wenig über die physiologische Rolle von Hera bekannt.
Linden, Martin Hubert
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p68 RNA helicase - identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts [PDF]
, 2014 The human p68 protein is an RNA-dependent ATPase and RNA helicase which was first identified because of its immunological cross-reaction with a viral RNA helicase, simian virus 40 large T antigen.
Jamieson, DJ +5 more
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Comparative structural analysis of human DEAD-box RNA helicases. [PDF]
PLoS ONE, 2010 DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections.
Patrick Schütz +12 more
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PLoS Pathogens, 2019 Positive-stranded RNA viruses replicate inside cells and depend on many co-opted cellular factors to complete their infection cycles. To combat viruses, the hosts use conserved restriction factors, such as DEAD-box RNA helicases, which can function as ...
Cheng-Yu Wu, Peter D Nagy
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