Results 21 to 30 of about 32,587 (229)

DEAD-box RNA helicases in Escherichia coli [PDF]

Nucleic Acids Research, 2006
In spite of their importance in RNA metabolism, the function of DExD/H-box proteins (including DEAD-box proteins) is poorly understood at the molecular level. Here, we present recent progress achieved with the five DEAD-box proteins from Escherichia coli, which have been particularly well studied. These proteins, which have orthologues in many bacteria,
Iost, Isabelle, Dreyfus, Marc
openaire   +2 more sources

The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity

iScience, 2020
Summary: Members of the DEAD-box helicase family are involved in all fundamental processes of RNA metabolism, and as such, their malfunction is associated with various diseases.
Maria J. Marcaida, Annamaria Kauzlaric, Alice Duperrex, Jenny Sülzle, Martin C. Moncrieffe, Damilola Adebajo, Suliana Manley, Didier Trono, Matteo Dal Peraro   +8 more
doaj   +1 more source

Genome-wide comparative in silico analysis of the RNA helicase gene family in Zea mays and Glycine max: a comparison with Arabidopsis and Oryza sativa. [PDF]

PLoS ONE, 2013
RNA helicases are enzymes that are thought to unwind double-stranded RNA molecules in an energy-dependent fashion through the hydrolysis of NTP. RNA helicases are associated with all processes involving RNA molecules, including nuclear transcription ...
Ruirui Xu, Shizhong Zhang, Jinguang Huang, Chengchao Zheng   +3 more
doaj   +1 more source

DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection

Frontiers in Cellular and Infection Microbiology, 2021
Previous studies have shown that DEAD (Asp-Glu-Ala-Asp)-box RNA helicases play important roles in viral infection, either as cytosolic sensors of pathogenic molecules or as essential host factors against viral infection.
Rui Zhang, Min Cheng, Bingxin Liu, Meng Yuan, Deyan Chen, Yujiong Wang, Zhiwei Wu, Zhiwei Wu, Zhiwei Wu, Zhiwei Wu   +9 more
doaj   +1 more source

DEAD-Box RNA Helicase DDX47 Maintains Midgut Homeostasis in Locusta migratoria. [PDF]

Int J Mol Sci, 2022
Tissue homeostasis is critical for maintaining organ shape, size, and function. The condition is regulated by the balance between the generation of new cells and the loss of senescent cells, and it involves many factors and mechanisms. The midgut, an important part of the intestinal tract, is responsible for digestion and nutrient absorption in insects.
Wang JX, Ma EB, Zhang JZ, Xing SP.
europepmc   +3 more sources

Targeting host DEAD-box RNA helicase DDX3X for treating viral infections. [PDF]

Antiviral Res, 2021
DDX3X or DDX3, a member of the DEAD (asp, glu, ala, asp) box RNA helicase family of proteins, is a multifunctional protein, which is usurped by several viruses and is vital to their production. To date, 18 species of virus from 12 genera have been demonstrated to be dependent on DDX3 for virulence.
Winnard PT, Vesuna F, Raman V.
europepmc   +3 more sources

The emerging role of DEAD/H-box helicases in hepatitis B virus infection

Frontiers in Cellular and Infection Microbiology, 2022
DEAD/H-box helicases are an essential protein family with a conserved motif containing unique amino acid sequences (Asp-Glu-Ala-Asp/His). Current evidence indicates that DEAD/H-box helicases regulate RNA metabolism and innate immune responses.
Hongjuan You, Lihong Ma, Xing Wang, Fulong Zhang, Yiran Han, Jiaqi Yao, Xiucheng Pan, Kuiyang Zheng, Kuiyang Zheng, Fanyun Kong, Renxian Tang, Renxian Tang   +11 more
doaj   +1 more source

DEAD‐box proteins as RNA helicases and chaperones [PDF]

WIREs RNA, 2010
AbstractDEAD‐box proteins are ubiquitous in RNA‐mediated processes and function by coupling cycles of ATP binding and hydrolysis to changes in affinity for single‐stranded RNA. Many DEAD‐box proteins use this basic mechanism as the foundation for a version of RNA helicase activity, efficiently separating the strands of short RNA duplexes in a process ...
Inga, Jarmoskaite, Rick, Russell
openaire   +2 more sources

Allosteric activation of RhlB by RNase E induces partial duplex opening in substrate RNA

Frontiers in Molecular Biosciences, 2023
The E. coli DEAD-Box helicase RhlB is responsible for ATP-dependent unwinding of structured mRNA to facilitate RNA degradation by the protein complex degradosome.
Heidi Zetzsche, Laura Raschke, Boris Fürtig   +2 more
doaj   +1 more source

The DEAD box RNA helicase family in Arabidopsis thaliana [PDF]

Nucleic Acids Research, 1999
The numerous genomic sequences and ESTs released by the Arabidopsis thaliana Genome Initiative (AGI) have allowed a systematic and functional study of the DEAD box RNA helicase family. Sequencing and in silico analysis led to the characterization of 28 novel A. thaliana DEAD box RNA helicases forming a family of 32 members, named AtRH.
Aubourg, Sébastien, Kreis, M., Lecharny, A.   +2 more
openaire   +3 more sources