Results 31 to 40 of about 2,112,303 (205)

Role of DEAD-box RNA helicase genes in the growth of Yersinia pseudotuberculosis IP32953 under cold, pH, osmotic, ethanol and oxidative stresses.

PLoS ONE, 2019
Yersinia pseudotuberculosis is an important foodborne pathogen threatening modern food safety due to its ability to survive and grow at low temperatures. DEAD-box RNA helicase CsdA has been shown to play an important role in the low-temperature growth of
Xiaojie Jiang, Riikka Keto-Timonen, Mikael Skurnik, Hannu Korkeala   +3 more
doaj   +1 more source

ATPase cycle and DNA unwinding kinetics of RecG helicase [PDF]

, 2012
The superfamily 2 bacterial helicase, RecG, is a monomeric enzyme with a role in DNA repair by reversing stalled replication forks. The helicase must act specifically and rapidly to prevent replication fork collapse. We have shown that RecG binds tightly
Webb, Martin R, Powell, Ben, Ben Powell (159692), Toseland, Christopher P., Powell Ben, Webb Martin R., Toseland Christopher P., Martin R Webb, Christopher P Toseland, Ben Powell, Christopher P. Toseland (13866), Martin R. Webb (159695)   +11 more
core   +1 more source

The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster. [PDF]

, 2011
Gene expression is highly dynamic and many genes show a wide range in expression over several orders of magnitude. This regulation is often mediated by sequence specific transcription factors.
Bag, I., M. Janaki Ramaiah, Ramaiah, M.J., Bag, Indira, Irene Vetter, Boeke Joern, Kremmer Elisabeth, Vetter, I., Imhof Axel, Bhadra Utpal, Bhadra, U., Kremmer, E., Boeke, J., Kremmer, Elisabeth, Axel Imhof, Manika Pal-Bhadra, Boeke, Joern, Utpal Bhadra, Pal-Bhadra, Manika, Indira Bag, Vetter, Irene, Vetter Irene, M Janaki Ramaiah, Pal-Bhadra Manika, Imhof, Axel, Pal-Bhadra, M., Joern Boeke, Bhadra, Utpal, Ramaiah, M. Janaki, Imhof, A., Bag Indira, Elisabeth Kremmer, Ramaiah M. Janaki   +32 more
core   +2 more sources

Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy

Frontiers in Oncology, 2023
DEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including transcription, pre-mRNA splicing, ribosomes biogenesis, nuclear export, translation initiation, RNA degradation, and mRNA editing.
Ananna Bhadra Arna, Hardikkumar Patel, Ravi Shankar Singh, Frederick S. Vizeacoumar, Anthony Kusalik, Andrew Freywald, Franco J. Vizeacoumar, Yuliang Wu   +7 more
doaj   +1 more source

Heterogeneous dissociation process of truncated RNAs by oligomerized Vasa helicase

Communications Biology, 2021
Kinoshita et al. use single molecule imaging to show that the N-terminal extension of BmVasa, a germ-specific DEAD box RNA helicase, is necessary for protein oligomerization and the dissociation of target RNA from the Siwi-piRISC complex.
Yoshimi Kinoshita, Ryo Murakami, Nao Muto, Shintaroh Kubo, Ryo Iizuka, Sotaro Uemura   +5 more
doaj   +1 more source

ATPase mechanism of the 5'-3' DNA helicase, RecD2: evidence for a pre-hydrolysis conformation change [PDF]

, 2013
The superfamily 1 helicase, RecD2, is a monomeric, bacterial enzyme with a role in DNA repair, but with 5'-3' activity unlike most enzymes from this superfamily. Rate constants were determined for steps within the ATPase cycle of RecD2 in the presence of
Webb, Martin R, Toseland, Christopher P.
core   +1 more source

RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis

Cell Reports, 2019
Summary: DDX17, a DEAD-box ATPase, is a multifunctional helicase important for various RNA functions, including microRNA maturation. Key questions for DDX17 include how it recognizes target RNAs and influences their structures, as well as how its ATPase ...
Tri D. Ngo, Alexander C. Partin, Yunsun Nam   +2 more
doaj   +1 more source

Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase [PDF]

, 2008
In yeast, three small nucleolar RNAs (snoRNAs) are essential for the processing of pre-ribosomal RNA—U3, U14 and snR30—whereas 72 non-essential snoRNAs direct site-specific modification of pre-rRNA. We applied a quantitative screen for alterations in the
Martin Kos, Markus T Bohnsack, Bohnsack, Markus T., Tollervey, David, David Tollervey, Kos, Martin, Bohnsack, Markus   +6 more
core   +1 more source

Molecular insights into RNA and DNA helicase evolution from the determinants of specificity for a DEAD-box RNA helicase

eLife, 2014
How different helicase families with a conserved catalytic ‘helicase core’ evolved to function on varied RNA and DNA substrates by diverse mechanisms remains unclear.
Anna L Mallam, David J Sidote, Alan M Lambowitz   +2 more
doaj   +1 more source

Splicing Factor DDX23, Transcriptionally Activated by E2F1, Promotes Ovarian Cancer Progression by Regulating FOXM1

Frontiers in Oncology, 2021
Ovarian carcinoma remains the most lethal gynecological carcinoma. Abnormal expression of splicing factors is closely related to the occurrence and development of tumors.
Chen Zhao, Chen Zhao, Yingwei Li, Yingwei Li, Chunping Qiu, Chunping Qiu, Jingying Chen, Jingying Chen, Huan Wu, Huan Wu, Qiuman Wang, Qiuman Wang, Xinyue Ma, Xinyue Ma, Kun Song, Kun Song, Beihua Kong, Beihua Kong   +17 more
doaj   +1 more source