Results 51 to 60 of about 32,587 (229)

Heterogeneous dissociation process of truncated RNAs by oligomerized Vasa helicase

Communications Biology, 2021
Kinoshita et al. use single molecule imaging to show that the N-terminal extension of BmVasa, a germ-specific DEAD box RNA helicase, is necessary for protein oligomerization and the dissociation of target RNA from the Siwi-piRISC complex.
Yoshimi Kinoshita, Ryo Murakami, Nao Muto, Shintaroh Kubo, Ryo Iizuka, Sotaro Uemura   +5 more
doaj   +1 more source

The helicase HAGE prevents interferon-a-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1 [PDF]

, 2014
The tumour suppressor PML (promyelocytic leukaemia protein) regulates several cellular pathways involving cell growth, apoptosis, differentiation and senescence.
A Carracedo, A Hauschild, A Jankowsky, A Kakizuka, AA Tarhini, AJ Linley, BJ Wilson, C Gurrieri, C Lavau, C Schindler, D Ungureanu, DJ Groskreutz, G Marie-Claude, GB Lesinski, H de The, J Borrow, K Ito, K Wheatley, M Stadler, MK Chelbi-Alix, NY Frank, O Cordin, P Salomoni, RAR Piganis, S Aaronson, T Kamura, T Regad, T Regad, T Regad, T Schatton, TA Endo, W Condemine, WB Dias, Z Li   +33 more
core   +1 more source

The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs. [PDF]

, 2018
The conserved and essential DEAD-box RNA helicase Ded1p from yeast and its mammalian orthologue DDX3 are critical for the initiation of translation1.
Bartel, David P, Brar, Gloria A, Guenther, Ulf-Peter, Jankowsky, Eckhard, Licatalosi, Donny D, Stawicki, Brittany N, Tedeschi, Frank A, Weinberg, David E, Weissman, Jonathan S, Zagore, Leah L, Zubradt, Meghan M   +10 more
core   +1 more source

Vasa-Like DEAD-Box RNA Helicases of Schistosoma mansoni

PLoS Neglected Tropical Diseases, 2012
Genome sequences are available for the human blood flukes, Schistosoma japonicum, S. mansoni and S. haematobium. Functional genomic approaches could aid in identifying the role and importance of these newly described schistosome genes. Transgenesis is established for functional genomics in model species, which can lead to gain- or loss-of-functions ...
Danielle E Skinner, Gabriel Rinaldi, Sutas Suttiprapa, Victoria H Mann, Pablo Smircich, Alexis A Cogswell, David L Williams, Paul J Brindley   +7 more
openaire   +4 more sources

Molecular insights into RNA and DNA helicase evolution from the determinants of specificity for a DEAD-box RNA helicase

eLife, 2014
How different helicase families with a conserved catalytic ‘helicase core’ evolved to function on varied RNA and DNA substrates by diverse mechanisms remains unclear.
Anna L Mallam, David J Sidote, Alan M Lambowitz   +2 more
doaj   +1 more source

ATPase cycle and DNA unwinding kinetics of RecG helicase [PDF]

, 2012
The superfamily 2 bacterial helicase, RecG, is a monomeric enzyme with a role in DNA repair by reversing stalled replication forks. The helicase must act specifically and rapidly to prevent replication fork collapse. We have shown that RecG binds tightly
Powell, Ben, Toseland, Christopher P., Webb, Martin R   +2 more
core   +4 more sources

DEAD-Box RNA Helicases in Gram-Positive RNA Decay

, 2012
DEAD-box RNA helicases are important players in eukaryotic and bacterial RNA metabolism. A helicase from Staphylococcus aureus was recently shown to affect RNA decay, most likely via its interaction with the proposed Gram-positive degradosome. Some, but not all, RNAs are stabilized when the helicase CshA is mutated, and among the affected RNAs is the ...
Redder Peter, Linder Patrick
openaire   +3 more sources

RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis

Cell Reports, 2019
Summary: DDX17, a DEAD-box ATPase, is a multifunctional helicase important for various RNA functions, including microRNA maturation. Key questions for DDX17 include how it recognizes target RNAs and influences their structures, as well as how its ATPase ...
Tri D. Ngo, Alexander C. Partin, Yunsun Nam   +2 more
doaj   +1 more source

Splicing Factor DDX23, Transcriptionally Activated by E2F1, Promotes Ovarian Cancer Progression by Regulating FOXM1

Frontiers in Oncology, 2021
Ovarian carcinoma remains the most lethal gynecological carcinoma. Abnormal expression of splicing factors is closely related to the occurrence and development of tumors.
Chen Zhao, Chen Zhao, Yingwei Li, Yingwei Li, Chunping Qiu, Chunping Qiu, Jingying Chen, Jingying Chen, Huan Wu, Huan Wu, Qiuman Wang, Qiuman Wang, Xinyue Ma, Xinyue Ma, Kun Song, Kun Song, Beihua Kong, Beihua Kong   +17 more
doaj   +1 more source

Conserved requirement for DEAD-box RNA helicase Gemin3 in Drosophila oogenesis [PDF]

, 2012
Background: DEAD-box RNA helicase Gemin3 is an essential protein since its deficiency is lethal in both vertebrates and invertebrates. In addition to playing a role in transcriptional regulation and RNA silencing, as a core member of the SMN (survival of
Cauchi, Ruben J.
core   +3 more sources