Results 71 to 80 of about 2,112,303 (205)

Dual-level autoregulation of the E. coli DeaD RNA helicase via mRNA stability and Rho-dependent transcription termination [PDF]

open access: yes, 2020
DEAD-box proteins (DBPs) are RNA remodeling factors associated with RNA helicase activity that are found in nearly all organisms. Despite extensive studies on the mechanisms used by DBPs to regulate RNA function, very little is known about how DBPs ...
Ojha, Sandeep, Jain, Chaitanya
core   +1 more source

Developing Metal–Polyphenol Network‐Based Single‐Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia

open access: yesAdvanced Science, EarlyView.
Sarcopenia has emerged as a major health challenge in the aging population. Developing a sustained‐release system for whey protein may enhance its effectiveness in mitigating sarcopenia. Herein, a novel “single‐protein particle encapsulation” (SPPE) system is developed to protect whey protein and control its release.
Yafei Zhang   +11 more
wiley   +1 more source

DEAD-box helicase family proteins: emerging targets in digestive system cancers and advances in targeted drug development

open access: yesJournal of Translational Medicine
Cancer has become one of the major diseases threatening human health in the twenty-first century due to its incurability. In 2022, new cases of esophageal and gastrointestinal cancers accounted for 17.1% of all newly diagnosed cancer cases worldwide ...
Xiaochao Ma   +6 more
doaj   +1 more source

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.

open access: yesPLoS Pathogens, 2018
DExD/H box RNA helicases, such as the RIG-I-like receptors (RLR), are important components of the innate immune system. Here we demonstrate a pivotal and sex-specific role for the heterosomal isoforms of the DEAD box RNA helicase DDX3 in the immune ...
Daniel Szappanos   +14 more
doaj   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

open access: yesAnimal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu   +8 more
wiley   +1 more source

The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5

open access: yesStem Cells International, 2017
DDX3 is a member of the family of DEAD-box RNA helicases. DDX3 is a multifaceted helicase and plays essential roles in key biological processes such as cell cycle, stress response, apoptosis, and RNA metabolism.
Abdullah Shah   +6 more
doaj   +1 more source

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: The Study of Muscle, Mobility and Aging

open access: yesArthritis &Rheumatology, EarlyView.
Objective The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). Methods Inclusion criteria included knee radiographs and bulk RNA sequencing in vastus lateralis muscle, resulting in 523 participants (56% female).
Daniel S. Evans   +7 more
wiley   +1 more source

Helicase binding to DnaI exposes a cryptic DNA-binding site during helicase loading in Bacillus subtilis [PDF]

open access: yes, 1981
The Bacillus subtilis DnaI, DnaB and DnaD proteins load the replicative ring helicase DnaC onto DNA during priming of DNA replication. Here we show that DnaI consists of a C-terminal domain (Cd) with ATPase and DNA-binding activities and an N-terminal ...
Shi, Wei   +999 more
core   +49 more sources

DEAD-Box RNA Helicases and Genome Stability

open access: yes, 2021
DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome ...
Stanley Lee   +2 more
core   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

open access: yesBMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang   +9 more
wiley   +1 more source

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