Results 91 to 100 of about 32,587 (229)

Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas. [PDF]

, 2020
MYC-driven lymphomas, especially those with concurrent MYC and BCL2 dysregulation, are currently a challenge in clinical practice due to rapid disease progression, resistance to standard chemotherapy, and high risk of refractory disease.
Bi, Chengfeng, Brown, Lauren E., Devine, William G., Fu, Kai, Hao, Xinbao, Huang, Yuhua, Lu, Ting, Lunning, Matthew, Porco, John A., Tian, Tian, Vose, Julie, Wang, Cheng, Yue, Ting, Zhang, Weiwei, Zhang, Xiaoyan, Zhang, Xuan   +15 more
core   +1 more source

MDM2 Mediates Nonproteolytic Polyubiquitylation of the DEAD-Box RNA Helicase DDX24 [PDF]

Molecular and Cellular Biology, 2014
MDM2 mediates the ubiquitylation and thereby triggers the proteasomal degradation of the tumor suppressor protein p53. However, genetic evidence suggests that MDM2 contributes to multiple regulatory networks independently of p53 degradation. We have now identified the DEAD-box RNA helicase DDX24 as a nucleolar protein that interacts with MDM2.
Takayoshi, Yamauchi, Masaaki, Nishiyama, Toshiro, Moroishi, Kanae, Yumimoto, Keiichi I, Nakayama   +4 more
openaire   +2 more sources

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop [PDF]

, 2017
DEAD-box proteins disrupt or remodel RNA and protein/RNA complexes at the expense of ATP. The catalytic core is composed of two flexibly connected RecA-like domains.
Diederichsen, Ulf, Hertel, Ines, Klostermeier, Dagmar, Rudolph, Markus G., Strohmeier, Julian   +4 more
core  

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.

PLoS Pathogens, 2018
DExD/H box RNA helicases, such as the RIG-I-like receptors (RLR), are important components of the innate immune system. Here we demonstrate a pivotal and sex-specific role for the heterosomal isoforms of the DEAD box RNA helicase DDX3 in the immune ...
Daniel Szappanos, Roland Tschismarov, Thomas Perlot, Sandra Westermayer, Katrin Fischer, Ekaterini Platanitis, Fabian Kallinger, Maria Novatchkova, Caroline Lassnig, Mathias Müller, Veronika Sexl, Keiryn L Bennett, Michelle Foong-Sobis, Josef M Penninger, Thomas Decker   +14 more
doaj   +1 more source

Putative SF2 helicases of the early-branching eukaryote Giardia lamblia are involved in antigenic variation and parasite differentiation into cysts

BMC Microbiology, 2012
Background Regulation of surface antigenic variation in Giardia lamblia is controlled post-transcriptionally by an RNA-interference (RNAi) pathway that includes a Dicer-like bidentate RNase III (gDicer).
Gargantini Pablo R, Serradell Marianela C, Torri Alessandro, Lujan Hugo D   +3 more
doaj   +1 more source

Omnipresent Maxwell’s demons orchestrate information management in living cells [PDF]

, 2019
The development of synthetic biology calls for accurate understanding of the critical functions that allow construction and operation of a living cell.
Danchin, Antoine, Gregory Boel, Olivier Danot, Victor de Lorenzo, Antoine Danchin   +1 more
core  

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

DEAD-box helicase family proteins: emerging targets in digestive system cancers and advances in targeted drug development

Journal of Translational Medicine
Cancer has become one of the major diseases threatening human health in the twenty-first century due to its incurability. In 2022, new cases of esophageal and gastrointestinal cancers accounted for 17.1% of all newly diagnosed cancer cases worldwide ...
Xiaochao Ma, Tianyu Lu, Yue Yang, Da Qin, Ze Tang, Youbin Cui, Rui Wang   +6 more
doaj   +1 more source