Results 11 to 20 of about 32,587 (229)

DEAD box RNA helicase functions in cancer [PDF]

RNA Biology, 2013
Members of the DEAD box family of RNA helicases are known to be involved in most cellular processes that require manipulation of RNA structure and, in many cases, exhibit other functions in addition to their established ATP-dependent RNA helicase activities.
Frances V Fuller-Pace
openaire   +5 more sources

Comparative structural analysis of human DEAD-box RNA helicases. [PDF]

PLoS ONE, 2010
DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections.
Patrick Schütz, Tobias Karlberg, Susanne van den Berg, Ruairi Collins, Lari Lehtiö, Martin Högbom, Lovisa Holmberg-Schiavone, Wolfram Tempel, Hee-Won Park, Martin Hammarström, Martin Moche, Ann-Gerd Thorsell, Herwig Schüler   +12 more
doaj   +4 more sources

From unwinding to clamping — the DEAD box RNA helicase family

Nature Reviews Molecular Cell Biology, 2011
RNA helicases of the DEAD box family are present in all eukaryotic cells and in many bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism from transcription to degradation and are therefore important players in gene expression.
Linder Patrick, Jankowsky Eckhard
openaire   +6 more sources

Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies

Genes and Diseases
Hematopoiesis represents a meticulously regulated and dynamic biological process. Genetic aberrations affecting blood cells, induced by various factors, frequently give rise to hematological tumors. These instances are often accompanied by a multitude of
Jiankun Fan, Zhigang Li, Li Pei, Yu Hou
doaj   +3 more sources

The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5 [PDF]

Stem Cells International, 2017
DDX3 is a member of the family of DEAD-box RNA helicases. DDX3 is a multifaceted helicase and plays essential roles in key biological processes such as cell cycle, stress response, apoptosis, and RNA metabolism.
Abdullah Shah, Farooq Rashid, Hassaan Mehboob Awan, Shanshan Hu, Xiaolin Wang, Liang Chen, Ge Shan   +6 more
doaj   +3 more sources

DEAD-Box RNA Helicases and Genome Stability [PDF]

Genes, 2021
DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome. Current studies have provided insight into the connection between genomic stability and several DEAD-box ...
Michael Cargill, Rasika Venkataraman, Stanley Lee   +2 more
openaire   +2 more sources

A DEAD-box RNA helicase mediates meiotic silencing by unpaired DNA. [PDF]

G3 (Bethesda), 2023
Abstract During the sexual phase of Neurospora crassa, unpaired genes are subject to a silencing mechanism known as meiotic silencing by unpaired DNA (MSUD). MSUD targets the transcripts of an unpaired gene and utilizes typical RNA interference factors for its process.
Sy VT, Boone EC, Xiao H, Vierling MM, Schmitz SF, Ung Q, Trawick SS, Hammond TM, Shiu PKT.   +8 more
europepmc   +3 more sources

The DEAD-Box RNA Helicase Ded1 Is Associated with Translating Ribosomes. [PDF]

Genes (Basel), 2023
DEAD-box RNA helicases are ATP-dependent RNA binding proteins and RNA-dependent ATPases that possess weak, nonprocessive unwinding activity in vitro, but they can form long-lived complexes on RNAs when the ATPase activity is inhibited. Ded1 is a yeast DEAD-box protein, the functional ortholog of mammalian DDX3, that is considered important for the ...
Yeter-Alat H, Belgareh-Touzé N, Huvelle E, Banroques J, Tanner NK.   +4 more
europepmc   +3 more sources

Bacterial versatility requires DEAD-box RNA helicases [PDF]

FEMS Microbiology Reviews, 2015
RNA helicases of the DEAD-box and DEAH-box families are important players in many processes involving RNA molecules. These proteins can modify RNA secondary structures or intermolecular RNA interactions and modulate RNA-protein complexes. In bacteria, they are known to be involved in ribosome biogenesis, RNA turnover and translation initiation.
Redder P., Hausmann S., Khemici V., Yasrebi H., Linder P.   +4 more
openaire   +5 more sources

AMP Sensing by DEAD-Box RNA Helicases [PDF]

Journal of Molecular Biology, 2013
In eukaryotes, cellular levels of adenosine monophosphate (AMP) signal the metabolic state of the cell. AMP concentrations increase significantly upon metabolic stress, such as glucose deprivation in yeast. Here, we show that several DEAD-box RNA helicases are sensitive to AMP, which is not produced during ATP hydrolysis by these enzymes.
Andrea A, Putnam, Eckhard, Jankowsky
openaire   +2 more sources