Crystal structure of the human ATP-dependent splicing and export factor UAP56 [PDF]
, 2004 Pre-mRNA splicing requires the function of a number of RNA-dependent ATPases/helicases, yet no three-dimensional structure of any spliceosomal ATPases/helicases is known.
Shi, H. +4 more
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DEAD box RNA helicase functions in cancer [PDF]
RNA Biology, 2013 Members of the DEAD box family of RNA helicases are known to be involved in most cellular processes that require manipulation of RNA structure and, in many cases, exhibit other functions in addition to their established ATP-dependent RNA helicase activities.
openaire +3 more sources
DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease
Cells, 2022 DEAD/H-box proteins are the largest family of RNA helicases in mammalian genomes, and they are present in all kingdoms of life. Since their discovery in the late 1980s, DEAD/H-box family proteins have been a major focus of study.
Parimal Samir, Thirumala-Devi Kanneganti
doaj +1 more source
A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication [PDF]
, 2011 DEAD-box proteins are enzymes endowed with nucleic acid-dependent ATPase, RNA translocase and unwinding activities. The human DEAD-box protein DDX3 has been shown to play important roles in tumor proliferation and viral infections.
Garbelli, Anna +4 more
core +1 more source
BMC Microbiology, 2012 Background Regulation of surface antigenic variation in Giardia lamblia is controlled post-transcriptionally by an RNA-interference (RNAi) pathway that includes a Dicer-like bidentate RNase III (gDicer).
Gargantini Pablo R +3 more
doaj +1 more source
Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer [PDF]
, 2017 Purpose: DEAD box protein 3 (DDX3) is an RNA helicase with oncogenic properties that shuttles between the cytoplasm and nucleus. The majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear DDX3 localization of yet unknown ...
Bol, Guus M. +10 more
core +2 more sources
The DHX33 RNA helicase promotes mRNA translation initiation [PDF]
, 2015 DEAD/DEAH box RNA helicases play essential roles in numerous RNA metabolic processes, such as mRNA translation, pre-mRNA splicing, ribosome biogenesis, and double-stranded RNA sensing.
Wang, Xingshun +3 more
core +2 more sources
ATPase cycle and DNA unwinding kinetics of RecG helicase [PDF]
, 2012 The superfamily 2 bacterial helicase, RecG, is a monomeric enzyme with a role in DNA repair by reversing stalled replication forks. The helicase must act specifically and rapidly to prevent replication fork collapse. We have shown that RecG binds tightly
Powell, Ben +2 more
core +4 more sources
Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12
Brazilian Journal of Medical and Biological Research, 2001 DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension
A.A. Camargo +6 more
doaj +1 more source
ATPase mechanism of the 5'-3' DNA helicase, RecD2: evidence for a pre-hydrolysis conformation change [PDF]
, 2013 The superfamily 1 helicase, RecD2, is a monomeric, bacterial enzyme with a role in DNA repair, but with 5'-3' activity unlike most enzymes from this superfamily. Rate constants were determined for steps within the ATPase cycle of RecD2 in the presence of
Bae +34 more
core +1 more source