Results 31 to 40 of about 10,061 (190)

DEAD-ly Affairs: The Roles of DEAD-Box Proteins on HIV-1 Viral RNA Metabolism

Frontiers in Cell and Developmental Biology, 2022
In order to ensure viral gene expression, Human Immunodeficiency virus type-1 (HIV-1) recruits numerous host proteins that promote optimal RNA metabolism of the HIV-1 viral RNAs (vRNAs), such as the proteins of the DEAD-box family. The DEAD-box family of
Shringar Rao, Tokameh Mahmoudi, Tokameh Mahmoudi, Tokameh Mahmoudi   +3 more
doaj   +1 more source

DEAD box RNA helicases are pervasive protein kinase interactors and activators. [PDF]

Genome Res
DEAD box (DDX) RNA helicases are a large family of ATPases, many of which have unknown functions. There is emerging evidence that besides their role in RNA biology, DDX proteins may stimulate protein kinases. To investigate if protein kinase–DDX interaction is a more widespread phenomenon, we conducted three orthogonal large-scale screens, including ...
Hirth A, Fatti E, Netz E, Acebron SP, Papageorgiou D, Švorinić A, Cruciat CM, Karaulanov E, Gopanenko A, Zhu T, Sinning I, Krijgsveld J, Kohlbacher O, Niehrs C.   +13 more
europepmc   +3 more sources

DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection

Frontiers in Cellular and Infection Microbiology, 2021
Previous studies have shown that DEAD (Asp-Glu-Ala-Asp)-box RNA helicases play important roles in viral infection, either as cytosolic sensors of pathogenic molecules or as essential host factors against viral infection.
Rui Zhang, Min Cheng, Bingxin Liu, Meng Yuan, Deyan Chen, Yujiong Wang, Zhiwei Wu, Zhiwei Wu, Zhiwei Wu, Zhiwei Wu   +9 more
doaj   +1 more source

DEAD box RNA helicase functions in cancer [PDF]

RNA Biology, 2013
Members of the DEAD box family of RNA helicases are known to be involved in most cellular processes that require manipulation of RNA structure and, in many cases, exhibit other functions in addition to their established ATP-dependent RNA helicase activities.
openaire   +3 more sources

DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease

Cells, 2022
DEAD/H-box proteins are the largest family of RNA helicases in mammalian genomes, and they are present in all kingdoms of life. Since their discovery in the late 1980s, DEAD/H-box family proteins have been a major focus of study.
Parimal Samir, Thirumala-Devi Kanneganti
doaj   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2-Mediated DNA Damage Response. [PDF]

Adv Sci (Weinh)
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Yang T, Shen T, Qiu Y, Zhang W, Zheng Z, Sun J, Yao Y, Yao M, Li J.   +8 more
europepmc   +2 more sources

Putative SF2 helicases of the early-branching eukaryote Giardia lamblia are involved in antigenic variation and parasite differentiation into cysts

BMC Microbiology, 2012
Background Regulation of surface antigenic variation in Giardia lamblia is controlled post-transcriptionally by an RNA-interference (RNAi) pathway that includes a Dicer-like bidentate RNase III (gDicer).
Gargantini Pablo R, Serradell Marianela C, Torri Alessandro, Lujan Hugo D   +3 more
doaj   +1 more source

Division of Labor in an Oligomer of the DEAD-Box RNA Helicase Ded1p [PDF]

Molecular Cell, 2015
Most aspects of RNA metabolism involve DEAD-box RNA helicases, enzymes that bind and remodel RNA and RNA-protein complexes in an ATP-dependent manner. Here we show that the DEAD-box helicase Ded1p oligomerizes in the cell and in vitro, and unwinds RNA as a trimer. Two protomers bind the single-stranded region of RNA substrates and load a third protomer
Putnam, Andrea A., Gao, Zhaofeng, Liu, Fei, Jia, Huijue, Yang, Quansheng, Jankowsky, Eckhard   +5 more
openaire   +2 more sources

The DEAD-Box RNA Helicase Ded1 Is Associated with Translating Ribosomes

Genes, 2023
DEAD-box RNA helicases are ATP-dependent RNA binding proteins and RNA-dependent ATPases that possess weak, nonprocessive unwinding activity in vitro, but they can form long-lived complexes on RNAs when the ATPase activity is inhibited. Ded1 is a yeast DEAD-box protein, the functional ortholog of mammalian DDX3, that is considered important for the ...
Yeter-Alat, Hilal, Belgareh-Touzé, Naïma, Huvelle, Emmeline, Banroques, Josette, Tanner, N   +4 more
openaire   +2 more sources

Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12

Brazilian Journal of Medical and Biological Research, 2001
DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension
A.A. Camargo, D.N. Nunes, H.B. Samaia, L. Liu, V.P. Collins, A.J.G. Simpson, E. Dias-Neto   +6 more
doaj   +1 more source