Results 11 to 20 of about 10,061 (190)
DEAD-Box RNA Helicases and Genome Stability [PDF]
Genes, 2021 DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome. Current studies have provided insight into the connection between genomic stability and several DEAD-box ...
Rasika Venkataraman, Stanley Lee
exaly +5 more sources
AMP Sensing by DEAD-Box RNA Helicases [PDF]
Journal of Molecular Biology, 2013 In eukaryotes, cellular levels of adenosine monophosphate (AMP) signal the metabolic state of the cell. AMP concentrations increase significantly upon metabolic stress, such as glucose deprivation in yeast. Here, we show that several DEAD-box RNA helicases are sensitive to AMP, which is not produced during ATP hydrolysis by these enzymes.
Eckhard Jankowsky, Andrea A Putnam
exaly +5 more sources
Selective pharmacological targeting of a DEAD box RNA helicase.
PLoS ONE, 2008 RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected
Lisa Lindqvist +11 more
doaj +8 more sources
Role of DEAD/DEAH-box helicases in immunity, infection and cancers
Cell Communication and SignalingDEAD/DEAH-box helicases (DDX) are integral RNA-binding proteins within the RNA helicase superfamily 2 (SF2), characterized by distinct DEAD (Asp-Glu-Ala-Asp) and DEAH (Asp-Glu-Ala-His) motifs.
Rex Devasahayam Arokia Balaya +3 more
doaj +2 more sources
DEAD-Box RNA Helicases DDX3X and DDX5 as Oncogenes or Oncosuppressors: A Network Perspective [PDF]
Cancers, 2022 Anna Garbelli +2 more
exaly +2 more sources
PLoS Pathogens, 2014 Replication of plus-strand RNA viruses depends on recruited host factors that aid several critical steps during replication. Several of the co-opted host factors bind to the viral RNA, which plays multiple roles, including mRNA function, as an assembly ...
Nikolay Kovalev, Peter D Nagy
doaj +2 more sources
Genera specific distribution of DEAD-box RNA helicases in cyanobacteria. [PDF]
Microb Genom, 2021 Although RNA helicases are essentially ubiquitous and perform roles in all stages of RNA metabolism, phylogenetic analysis of the DEAD (Asp-Glu-Ala-Asp)-box RNA helicase family in a single phylum has not been performed. Here, we performed a phylogenetic analysis on DEAD-box helicases from all currently available cyanobacterial genomes, comprising a ...
Whitford DS, Whitman BT, Owttrim GW.
europepmc +3 more sources
The DDX5/Dbp2 subfamily of DEAD-box RNA helicases. [PDF]
Wiley Interdiscip Rev RNA, 2019 The mammalian DEAD‐box RNA helicase DDX5, its paralog DDX17, and their orthologs in Saccharomyces cerevisiae and Drosophila melanogaster, namely Dbp2 and Rm62, define a subfamily of DEAD‐box proteins. Members from this subfamily share highly conserved protein sequences and cellular functions.
Xing Z, Ma WK, Tran EJ.
europepmc +4 more sources
The emerging role of DEAD/H-box helicases in hepatitis B virus infection
Frontiers in Cellular and Infection Microbiology, 2022 DEAD/H-box helicases are an essential protein family with a conserved motif containing unique amino acid sequences (Asp-Glu-Ala-Asp/His). Current evidence indicates that DEAD/H-box helicases regulate RNA metabolism and innate immune responses.
Hongjuan You +11 more
doaj +1 more source
Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy
Frontiers in Oncology, 2023 DEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including transcription, pre-mRNA splicing, ribosomes biogenesis, nuclear export, translation initiation, RNA degradation, and mRNA editing.
Ananna Bhadra Arna +7 more
doaj +1 more source