Results 11 to 20 of about 15,822 (213)
Vasa-Like DEAD-Box RNA Helicases of Schistosoma mansoni. [PDF]
PLoS Neglected Tropical Diseases, 2012 Genome sequences are available for the human blood flukes, Schistosoma japonicum, S. mansoni and S. haematobium. Functional genomic approaches could aid in identifying the role and importance of these newly described schistosome genes.
Danielle E Skinner +7 more
doaj +5 more sources
DEAD-Box RNA Helicases and Genome Stability. [PDF]
Genes (Basel), 2021 DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome. Current studies have provided insight into the connection between genomic stability and several DEAD-box ...
Cargill M, Venkataraman R, Lee S.
europepmc +5 more sources
Bacterial versatility requires DEAD-box RNA helicases [PDF]
FEMS Microbiology Reviews, 2015 RNA helicases of the DEAD-box and DEAH-box families are important players in many processes involving RNA molecules. These proteins can modify RNA secondary structures or intermolecular RNA interactions and modulate RNA-protein complexes. In bacteria, they are known to be involved in ribosome biogenesis, RNA turnover and translation initiation.
Peter Redder, stephane, Patrick Linder
exaly +6 more sources
DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense
Viruses, 2020 DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family have roles throughout cellular RNA metabolism from biogenesis to decay ...
Frances Taschuk, Sara Cherry
doaj +3 more sources
From unwinding to clamping — the DEAD box RNA helicase family
Nature Reviews Molecular Cell Biology, 2011 RNA helicases of the DEAD box family are present in all eukaryotic cells and in many bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism from transcription to degradation and are therefore important players in gene expression.
Patrick Linder, Eckhard Jankowsky
exaly +5 more sources
The DEAD-Box RNA Helicases of Bacillus subtilis as a Model to Evaluate Genetic Compensation Among Duplicate Genes [PDF]
Frontiers in Microbiology, 2018 The presence of duplicated genes in organisms is well documented. There is increasing interest in understanding how these genes subfunctionalize and whether functional overlap can explain the fact that some of these genes are dispensable.
José Antonio González-Gutiérrez +5 more
doaj +2 more sources
Role of DEAD/DEAH-box helicases in immunity, infection and cancers [PDF]
Cell Communication and SignalingDEAD/DEAH-box helicases (DDX) are integral RNA-binding proteins within the RNA helicase superfamily 2 (SF2), characterized by distinct DEAD (Asp-Glu-Ala-Asp) and DEAH (Asp-Glu-Ala-His) motifs.
Rex Devasahayam Arokia Balaya +3 more
doaj +2 more sources
DEAD-box helicases as integrators of RNA, nucleotide and protein binding [PDF]
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2013 DEAD-box helicases perform diverse cellular functions in virtually all steps of RNA metabolism from Bacteria to Humans. Although DEAD-box helicases share a highly conserved core domain, the enzymes catalyze a wide range of biochemical reactions. In addition to the well established RNA unwinding and corresponding ATPase activities, DEAD-box helicases ...
Eckhard Jankowsky
exaly +3 more sources
DEAD-Box Helicase Proteins Disrupt RNA Tertiary Structure Through Helix Capture [PDF]
PLoS Biology, 2014 DEAD-box helicase proteins accelerate folding and rearrangements of highly structured RNAs and RNA–protein complexes (RNPs) in many essential cellular processes. Although DEAD-box proteins have been shown to use ATP to unwind short RNA helices, it is not
Cannon, Brian +6 more
core +9 more sources
Genera specific distribution of DEAD-box RNA helicases in cyanobacteria. [PDF]
Microb Genom, 2021 Although RNA helicases are essentially ubiquitous and perform roles in all stages of RNA metabolism, phylogenetic analysis of the DEAD (Asp-Glu-Ala-Asp)-box RNA helicase family in a single phylum has not been performed. Here, we performed a phylogenetic analysis on DEAD-box helicases from all currently available cyanobacterial genomes, comprising a ...
Whitford DS, Whitman BT, Owttrim GW.
europepmc +3 more sources