Results 11 to 20 of about 10,578 (207)
DEAD-Box RNA Helicases and Genome Stability [PDF]
Genes, 2021 DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome. Current studies have provided insight into the connection between genomic stability and several DEAD-box ...
Rasika Venkataraman
exaly +6 more sources
Selective pharmacological targeting of a DEAD box RNA helicase. [PDF]
PLoS ONE, 2008 RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected
Lisa Lindqvist +11 more
doaj +9 more sources
AMP Sensing by DEAD-Box RNA Helicases [PDF]
Journal of Molecular Biology, 2013 In eukaryotes, cellular levels of adenosine monophosphate (AMP) signal the metabolic state of the cell. AMP concentrations increase significantly upon metabolic stress, such as glucose deprivation in yeast. Here, we show that several DEAD-box RNA helicases are sensitive to AMP, which is not produced during ATP hydrolysis by these enzymes.
Andrea Putnam, Eckhard Jankowsky
exaly +5 more sources
The DDX5/Dbp2 subfamily of DEAD-box RNA helicases. [PDF]
Wiley Interdiscip Rev RNA, 2019 The mammalian DEAD‐box RNA helicase DDX5, its paralog DDX17, and their orthologs in Saccharomyces cerevisiae and Drosophila melanogaster, namely Dbp2 and Rm62, define a subfamily of DEAD‐box proteins. Members from this subfamily share highly conserved protein sequences and cellular functions.
Xing Z, Ma WK, Tran EJ.
europepmc +5 more sources
DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense
Viruses, 2020 DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family have roles throughout cellular RNA metabolism from biogenesis to decay ...
Frances Taschuk, Sara Cherry
doaj +2 more sources
Bacterial versatility requires DEAD-box RNA helicases [PDF]
FEMS Microbiology Reviews, 2015 RNA helicases of the DEAD-box and DEAH-box families are important players in many processes involving RNA molecules. These proteins can modify RNA secondary structures or intermolecular RNA interactions and modulate RNA-protein complexes. In bacteria, they are known to be involved in ribosome biogenesis, RNA turnover and translation initiation.
Redder P. +4 more
openaire +5 more sources
DEAD box RNA helicase functions in cancer [PDF]
RNA Biology, 2013 Members of the DEAD box family of RNA helicases are known to be involved in most cellular processes that require manipulation of RNA structure and, in many cases, exhibit other functions in addition to their established ATP-dependent RNA helicase activities.
Fuller-Pace, Frances V.
openaire +4 more sources
Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy [PDF]
Frontiers in Oncology, 2023 DEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including transcription, pre-mRNA splicing, ribosomes biogenesis, nuclear export, translation initiation, RNA degradation, and mRNA editing.
Ananna Bhadra Arna +7 more
doaj +2 more sources
Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer [PDF]
Frontiers in Oncology, 2023 Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately, this disease is changing rapidly to a younger age, and in a more advanced stage
Bichun Zheng +4 more
doaj +2 more sources
Looking back on the birth of DEAD-box RNA helicases
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013 DEAD-box proteins represent the largest family of RNA helicases, present in all three kingdoms of life. They are involved in a variety of processes involving RNA metabolism and in some instances also in processes that use guide RNAs. Since their first descriptions in the late 1980s, the perception of their molecular activities has dramatically changed.
Linder, Patrick, Fuller-Pace, Frances
core +7 more sources