Results 21 to 30 of about 10,578 (207)
DEAD-Box RNA Helicases in Gram-Positive RNA Decay
, 2012 DEAD-box RNA helicases are important players in eukaryotic and bacterial RNA metabolism. A helicase from Staphylococcus aureus was recently shown to affect RNA decay, most likely via its interaction with the proposed Gram-positive degradosome. Some, but not all, RNAs are stabilized when the helicase CshA is mutated, and among the affected RNAs is the ...
Redder Peter, Linder Patrick
openaire +4 more sources
Structural basis for RNA-duplex unwinding by the DEAD-box helicase DbpA [PDF]
RNA, 2022 Abstract DEAD-box RNA helicases are implicated in most aspects of RNA biology, where these enzymes unwind short RNA duplexes in an ATP-dependent manner. During the central step of the unwinding cycle, the two domains of the helicase core form a distinct closed conformation that destabilizes the RNA duplex, which ultimately leads to ...
Wurm, Jan Philip
openaire +5 more sources
Role of DEAD/DEAH-box helicases in immunity, infection and cancers [PDF]
Cell Communication and SignalingDEAD/DEAH-box helicases (DDX) are integral RNA-binding proteins within the RNA helicase superfamily 2 (SF2), characterized by distinct DEAD (Asp-Glu-Ala-Asp) and DEAH (Asp-Glu-Ala-His) motifs.
Rex Devasahayam Arokia Balaya +3 more
doaj +2 more sources
DEAD-Box RNA Helicases DDX3X and DDX5 as Oncogenes or Oncosuppressors: A Network Perspective [PDF]
Cancers, 2022 Anna Garbelli +2 more
exaly +2 more sources
PLoS Pathogens, 2014 Replication of plus-strand RNA viruses depends on recruited host factors that aid several critical steps during replication. Several of the co-opted host factors bind to the viral RNA, which plays multiple roles, including mRNA function, as an assembly ...
Nikolay Kovalev, Peter D Nagy
doaj +2 more sources
RNA Silencing in the Antiviral Innate Immune Defence – Role of DEAD‐box RNA Helicases [PDF]
Scandinavian Journal of Immunology, 2010 AbstractRNA silencing is an efficient biochemical tool for gene knock downs as well as physiological phenomenon playing a major role in diverse biological processes. Recent knowledge suggests that the same protein families which mediate the experimental RNA interference (RNAi) in the fruit fly Drosophila melanogaster cells also contribute to the ...
J, Ulvila, D, Hultmark, M, Rämet
openaire +3 more sources
The role of DEAD- and DExH-box RNA helicases in neurodevelopmental disorders [PDF]
Frontiers in Molecular NeuroscienceNeurodevelopmental disorders (NDDs) represent a large group of disorders with an onset in the neonatal or early childhood period; NDDs include intellectual disability (ID), autism spectrum disorders (ASD), attention deficit hyperactivity disorders (ADHD),
Johannes Lederbauer +6 more
doaj +2 more sources
Genera specific distribution of DEAD-box RNA helicases in cyanobacteria. [PDF]
Microb Genom, 2021 Although RNA helicases are essentially ubiquitous and perform roles in all stages of RNA metabolism, phylogenetic analysis of the DEAD (Asp-Glu-Ala-Asp)-box RNA helicase family in a single phylum has not been performed. Here, we performed a phylogenetic analysis on DEAD-box helicases from all currently available cyanobacterial genomes, comprising a ...
Whitford DS, Whitman BT, Owttrim GW.
europepmc +3 more sources
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling [PDF]
FEBS Open BioEndothelial‐to‐mesenchymal transition (EndoMT), a widely recognized biological process leading to abnormal endothelial function, has been implicated in various cardiovascular pathologies.
Yu Zhang +7 more
doaj +2 more sources
The emerging role of DEAD/H-box helicases in hepatitis B virus infection
Frontiers in Cellular and Infection Microbiology, 2022 DEAD/H-box helicases are an essential protein family with a conserved motif containing unique amino acid sequences (Asp-Glu-Ala-Asp/His). Current evidence indicates that DEAD/H-box helicases regulate RNA metabolism and innate immune responses.
Hongjuan You +11 more
doaj +1 more source