Results 61 to 70 of about 1,270,992 (292)

ATPase mechanism of the 5'-3' DNA helicase, RecD2: evidence for a pre-hydrolysis conformation change [PDF]

, 2013
The superfamily 1 helicase, RecD2, is a monomeric, bacterial enzyme with a role in DNA repair, but with 5'-3' activity unlike most enzymes from this superfamily. Rate constants were determined for steps within the ATPase cycle of RecD2 in the presence of
Bae, Bird, Boulé, Brune, Brune, Cao, Chisty, Christopher P. Toseland, Cremo, Dillingham, Gu, Henn, Henn, Hiratsuka, Ivessa, Jameson, Leatherbarrow, Lohman, Manosas, Martin R. Webb, Moore, Nixon, Okoh, Rocha, Saikrishnan, Singleton, Slatter, Soultanas, Toseland, Toseland, Toseland, Toseland, Wang, Webb, Webb   +34 more
core   +1 more source

Transcription as a Threat to Genome Integrity [PDF]

, 2016
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés, Gaillard, Hélène   +1 more
core   +1 more source

Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer [PDF]

, 2017
Purpose: DEAD box protein 3 (DDX3) is an RNA helicase with oncogenic properties that shuttles between the cytoplasm and nucleus. The majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear DDX3 localization of yet unknown ...
Bol, Guus M., Buerger, Horst, Heerman van Voss, Marise R., Meeldijk, Jan, Offerhaus, G. Johan, Patel, Arvind H., Raman, Ana, Raman, Venu, van der Wall, Elsken, van Diest, Paul J., Vesuna, Farhad   +10 more
core   +6 more sources

Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer

Frontiers in Oncology, 2023
Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately, this disease is changing rapidly to a younger age, and in a more advanced stage
Bichun Zheng, Xudong Chen, Qiaoyun Ling, Quan Cheng, Shaoshun Ye   +4 more
doaj   +1 more source

Helicase activity on DNA as a propagating front [PDF]

, 2003
We develop a propagating front analysis, in terms of a local probability of zipping, for the helicase activity of opening up a double stranded DNA (dsDNA).
Alberts B., Betterton M. D., Bhattacharjee S. M., Bhattacharjee S. M., Bhattacharjee S. M., Lohman T. M.   +5 more
core   +2 more sources

Sequence analysis and genomic organization of Aphid lethal paralysis virus: a new member of the family Dicistroviridae [PDF]

, 2002
The complete nucleotide sequence of the genomic RNA of an aphid-infecting virus, Aphid lethal paralysis virus (ALPV), has been determined. The genome is 9812 nt in length and contains two long open reading frames (ORFs), which are separated by an ...
Clerivet, A., Dullemans, A.M., Heuvel, J.F.J.M., van den, Munster, M., van, Verbeek, M., Wilk, F., van der   +5 more
core   +2 more sources

From promoting to inhibiting: diverse roles of helicases in HIV-1 Replication

Retrovirology, 2012
Helicases hydrolyze nucleotide triphosphates (NTPs) and use the energy to modify the structures of nucleic acids. They are key players in every cellular process involving RNA or DNA. Human immunodeficiency virus type 1 (HIV-1) does not encode a helicase,
Lorgeoux Rene-Pierre, Guo Fei, Liang Chen   +2 more
doaj   +1 more source

High Levels of DEAH-Box Helicases Relate to Poor Prognosis and Reduction of DHX9 Improves Radiosensitivity of Hepatocellular Carcinoma

Frontiers in Oncology, 2022
BackgroundLiver hepatocellular carcinoma (LIHC), one of the most common primary malignancies, exhibits high levels of molecular and clinical heterogeneity.
Xi Chen, Xi Chen, Xi Chen, Letao Lin, Letao Lin, Letao Lin, Guanyu Chen, Guanyu Chen, Guanyu Chen, Huzheng Yan, Zhenyu Li, Zhenyu Li, Meigui Xiao, Meigui Xiao, Meigui Xiao, Xu He, Fujun Zhang, Fujun Zhang, Fujun Zhang, Yanling Zhang, Yanling Zhang, Yanling Zhang, Yanling Zhang   +22 more
doaj   +1 more source

RNA helicase 3.6.4.13 [PDF]

, 2013
EC number  3.6.4.13 Systematic name  ATP phosphohydrolase (RNA helix unwinding) Recommended name  RNA helicase Synonyms  1a NTPase/helicase [5]  ATP/dATP-dependent RNA helicase [32]  ATPase [1,36]  ATPase/RNA helicase [32]  ATPase/helicase [36,41]  BMV 1a protein [5]  BmL3-helicase [32]  Brr2p [50]  DBP2 [30]  DDX17 [12]  DDX19 [56]  DDX25 [
Schomburg, Dietmar, Schomburg, Ida
openaire   +1 more source

Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing [PDF]

Nucleic Acids Research, 2014
Helicases contribute to diverse biological processes including replication, transcription and translation. Recent reports suggest that unwinding of some helicases display repetitive activity, yet the functional role of the repetitiveness requires further investigation.
Koh, Hye Ran, Xing, Li, Kleiman, Lawrence, Myong, Sua   +3 more
openaire   +2 more sources