Results 61 to 70 of about 768,185 (263)
PLoS Pathogens, 2020 Positive-stranded (+)RNA viruses greatly exploit host cells to support viral replication. However, unlike many other pathogens, (+)RNA viruses code for only a limited number of genes, making them highly dependent on numerous co-opted host factors for ...
Cheng-Yu Wu, Peter D Nagy
doaj +1 more source
Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity
mBio, 2021 Innate immunity serves as the first barrier against virus infection. DEAD (Glu-Asp-Ala-Glu) box RNA helicases, originally considered to be involved in RNA processing and RNA unwinding, have been shown to play an important role in antiviral innate ...
Wei Wu +14 more
doaj +1 more source
p68 RNA helicase - identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts [PDF]
, 2014 The human p68 protein is an RNA-dependent ATPase and RNA helicase which was first identified because of its immunological cross-reaction with a viral RNA helicase, simian virus 40 large T antigen.
Jamieson, DJ +5 more
core +2 more sources
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
RNA Helicases on the Move [PDF]
Biophysical Journal, 2014 We have investigated the mechanical properties of the RNA-helicase-motor proteins in single-molecule assays using Magnetic Tweezers. RNA helicases are fundamental molecular motors that remodel RNA structures, DNA/RNA hybrids and RNA-protein complexes that are essential in gene regulation.
Saurabh, Raj +6 more
openaire +1 more source
Closing in on ATPase Activity by an RNA Helicase [PDF]
Structure, 2020 In this issue of Structure, Absmeier et al. (2020) describe the molecular mechanisms employed by an RNA helicase to prevent premature ATP hydrolysis upon nucleotide binding.
Sean J, Johnson, Matthew K, Yim
openaire +2 more sources
Selective pharmacological targeting of a DEAD box RNA helicase.
PLoS ONE, 2008 RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected
Lisa Lindqvist +11 more
doaj +1 more source
RNA helicase domains of viral origin in proteins of insect retrotransposons: possible source for evolutionary advantages [PDF]
PeerJ, 2017 Recently, a novel phenomenon of horizontal gene transfer of helicase-encoding sequence from positive-stranded RNA viruses to LINE transposons in insect genomes was described.
Sergey Y. Morozov +2 more
doaj +2 more sources
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source