Results 81 to 90 of about 768,185 (263)

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

RNA helicase 3.6.4.13 [PDF]

, 2013
EC number  3.6.4.13 Systematic name  ATP phosphohydrolase (RNA helix unwinding) Recommended name  RNA helicase Synonyms  1a NTPase/helicase [5]  ATP/dATP-dependent RNA helicase [32]  ATPase [1,36]  ATPase/RNA helicase [32]  ATPase/helicase [36,41]  BMV 1a protein [5]  BmL3-helicase [32]  Brr2p [50]  DBP2 [30]  DDX17 [12]  DDX19 [56]  DDX25 [
Schomburg, Dietmar, Schomburg, Ida
openaire   +1 more source

RNA helicase A is essential for normal gastrulation [PDF]

Proceedings of the National Academy of Sciences, 1998
RNA helicase A (RHA) is the human homologue of the Drosophila maleless protein, an essential factor for the development of male flies. Recently, it was shown that RHA cooperates with the cAMP-responsive element in mediating the cAMP-dependent transcriptional activation of a number of genes ...
C G, Lee, V, da Costa Soares, C, Newberger, K, Manova, E, Lacy, J, Hurwitz   +5 more
openaire   +2 more sources

ATPase activity profiling of three human DExD/H-box RNA helicases

SLAS Discovery
Human DExD/H-box RNA helicases are ubiquitous molecular motors that unwind and rearrange RNA secondary structures in an ATP-dependent manner. These enzymes play essential roles in nearly all aspects of RNA metabolism. While their biological functions are
Fengling Li, U Hang Chan, Julia Garcia Perez, Hong Zeng, Irene Chau, Yanjun Li, Almagul Seitova, Levon Halabelian   +7 more
doaj   +1 more source

Accessory factors of cytoplasmic viral RNA sensors required for antiviral innate immune response

Frontiers in Immunology, 2016
Type I interferon (IFN) induces many antiviral factors in host cells. RIG-I-like receptors (RLRs) are cytoplasmic viral RNA sensors that trigger the signal to induce the innate immune response that includes type I IFN production.
Hiroyuki eOshiumi, Hiroyuki eOshiumi, Takahisa eKouwaki, Tsukasa eSeya   +3 more
doaj   +1 more source

Allosteric activation of RhlB by RNase E induces partial duplex opening in substrate RNA

Frontiers in Molecular Biosciences, 2023
The E. coli DEAD-Box helicase RhlB is responsible for ATP-dependent unwinding of structured mRNA to facilitate RNA degradation by the protein complex degradosome.
Heidi Zetzsche, Laura Raschke, Boris Fürtig   +2 more
doaj   +1 more source

Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis [PDF]

, 2019
Eukaryotic ribosome biogenesis is a highly orchestrated process involving numerous assembly factors including ATP-dependent RNA helicases. The DEAH helicase DHX37 (Dhr1 in yeast) is activated by the ribosome biogenesis factor UTP14A to facilitate ...
van den Heuvel, Jasmin, Jinek, Martin; https://orcid.org/, Boneberg, Franziska M, Kutay, Ulrike; https://orcid.org/, Kobel, Lena, Bammert, Lukas, Bargsten, Katja, Brandmann, Tobias   +7 more
core   +1 more source

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

Advanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo, Chuanyin Wu, Miao Feng, Wenfan Luo, Rong Miao, Jinsheng Qian, Fan Wang, Chunlei Zhou, Bojuan Liu, Jiale Shao, Ziqi Xun, Yehui Xiong, Zhichao Zhao, Cailin Lei, Shanshan Zhu, Yulong Ren, Xin Wang, Xiuping Guo, Haiyang Wang, Zichao Li, Zhijun Cheng, Qibing Lin, Jianmin Wan   +22 more
wiley   +1 more source

Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium.

PLoS Pathogens, 2010
The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. We investigated the roles of each pattern recognition receptor in rhinovirus infection using primary bronchial ...
Louise Slater, Nathan W Bartlett, Jennifer J Haas, Jie Zhu, Simon D Message, Ross P Walton, Annemarie Sykes, Samer Dahdaleh, Deborah L Clarke, Maria G Belvisi, Onn M Kon, Takashi Fujita, Peter K Jeffery, Sebastian L Johnston, Michael R Edwards   +14 more
doaj   +1 more source

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source