Regulation and mechanisms of action of RNA helicases [PDF]
RNA BiologyRNA helicases are an evolutionary conserved class of nucleoside triphosphate dependent enzymes found in all kingdoms of life. Their cellular functions range from transcription regulation up to maintaining genomic stability and viral defence.
Nina Lang +2 more
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DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy [PDF]
Cells, 2021 Cell cycle is regulated through numerous signaling pathways that determine whether cells will proliferate, remain quiescent, arrest, or undergo apoptosis. Abnormal cell cycle regulation has been linked to many diseases.
Lu Zhang, Xiaogang Li
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Annotation and functional prediction of RNA helicases in Ustilago maydis [PDF]
IMA FungusRNA helicases are conserved enzymes found in both prokaryotes and eukaryotes. They function in all aspects of RNA metabolism and are known to influence various cellular and metabolic processes.
Amanda M. Seto, Barry J. Saville
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Targeting R-loops: diverse RNA helicases in R-loop resolution and their potential as targets for cancer therapy [PDF]
Frontiers in Cell and Developmental BiologyRNA helicases are enzymes that remodel RNA secondary structures and RNA-protein complexes using ATP-driven motor forces. They are known to participate in many essential cellular processes, including transcription, splicing, translation, RNA decay, and ...
Katherine Herrera +3 more
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RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration [PDF]
Frontiers in Genetics, 2022 Short repeated sequences of 3−6 nucleotides are causing a growing number of over 50 microsatellite expansion disorders, which mainly present with neurodegenerative features.
Lydia M. Castelli +6 more
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Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies [PDF]
Genes and DiseasesHematopoiesis represents a meticulously regulated and dynamic biological process. Genetic aberrations affecting blood cells, induced by various factors, frequently give rise to hematological tumors. These instances are often accompanied by a multitude of
Jiankun Fan, Zhigang Li, Li Pei, Yu Hou
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Role of DEAD-box RNA helicases in low-temperature adapted growth of Antarctic Pseudomonas syringae Lz4W [PDF]
Microbiology SpectrumPseudomonas syringae possesses genes for all five major DEAD-box RNA helicases, rhlE, srmB, csdA, dbpA, and rhlB, that are found in γ-proteobacteria.
Ashaq Hussain, Malay Kumar Ray
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The role of DEAD- and DExH-box RNA helicases in neurodevelopmental disorders [PDF]
Frontiers in Molecular NeuroscienceNeurodevelopmental disorders (NDDs) represent a large group of disorders with an onset in the neonatal or early childhood period; NDDs include intellectual disability (ID), autism spectrum disorders (ASD), attention deficit hyperactivity disorders (ADHD),
Johannes Lederbauer +6 more
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PLoS Pathogens, 2014 Replication of plus-strand RNA viruses depends on recruited host factors that aid several critical steps during replication. Several of the co-opted host factors bind to the viral RNA, which plays multiple roles, including mRNA function, as an assembly ...
Nikolay Kovalev, Peter D Nagy
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The composition and unrevealed immune role of non-RLR DExD/H box RNA helicases in fish [PDF]
Comparative Immunology ReportsThe large superfamily of DExD/H box RNA helicases are involved in various life processes, such as RNA metabolism, transcriptional regulation, translation, tumorigenesis, cell cycle, and viral infection, and RIG-like receptors (RLRs) in the superfamily ...
Shan Nan Chen, Xue Yun Peng, Pin Nie
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