DEAH-Box RNA Helicases in Pre-mRNA Splicing. [PDF]
Trends Biochem Sci, 2021 In eukaryotic cells, pre-mRNA splicing is catalyzed by the spliceosome, a highly dynamic molecular machinery that undergoes dramatic conformational and compositional rearrangements throughout the splicing cycle.
De Bortoli F, Espinosa S, Zhao R.
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Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation. [PDF]
Mol Cell, 2022 Sex differences are pervasive in human health and disease. One major key to sex-biased differences lies in the sex chromosomes. Although the functions of the X chromosome proteins are well appreciated, how they compare with their Y chromosome homologs ...
Shen H +9 more
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Annotation and functional prediction of RNA helicases in Ustilago maydis [PDF]
IMA FungusRNA helicases are conserved enzymes found in both prokaryotes and eukaryotes. They function in all aspects of RNA metabolism and are known to influence various cellular and metabolic processes.
Amanda M. Seto, Barry J. Saville
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RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration [PDF]
Frontiers in Genetics, 2022 Short repeated sequences of 3−6 nucleotides are causing a growing number of over 50 microsatellite expansion disorders, which mainly present with neurodegenerative features.
Lydia M. Castelli +6 more
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RNA Helicases as Shadow Modulators of Cell Cycle Progression. [PDF]
Int J Mol Sci, 2021 The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-dependent kinases. However, many proteins that control DNA replication, RNA transcription and the synthesis and degradation of proteins can manage the activity or ...
Sergeeva O, Zatsepin T.
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RNA helicases are hubs that orchestrate exosome-dependent 3'-5' decay. [PDF]
Curr Opin Struct Biol, 2021 The RNA exosome is a conserved complex of proteins that mediates 3'-5' RNA processing and decay. Its functions range from processing of non-coding RNAs such as ribosomal RNAs and decay of aberrant transcripts in the nucleus to cytoplasmic mRNA turnover ...
Weick EM, Lima CD.
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Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies [PDF]
Genes and DiseasesHematopoiesis represents a meticulously regulated and dynamic biological process. Genetic aberrations affecting blood cells, induced by various factors, frequently give rise to hematological tumors. These instances are often accompanied by a multitude of
Jiankun Fan, Zhigang Li, Li Pei, Yu Hou
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Role of DEAD-box RNA helicases in low-temperature adapted growth of Antarctic Pseudomonas syringae Lz4W [PDF]
Microbiology SpectrumPseudomonas syringae possesses genes for all five major DEAD-box RNA helicases, rhlE, srmB, csdA, dbpA, and rhlB, that are found in γ-proteobacteria.
Ashaq Hussain, Malay Kumar Ray
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, 2012 RNA helikaze su visoko konzervirani enzimi prisutni u sve tri domene života te u nekim virusima. Uključeni su u sve korake RNA metabolizma od transkripcije do degradacije.
Kovačević, Alen
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The role of DEAD- and DExH-box RNA helicases in neurodevelopmental disorders [PDF]
Frontiers in Molecular NeuroscienceNeurodevelopmental disorders (NDDs) represent a large group of disorders with an onset in the neonatal or early childhood period; NDDs include intellectual disability (ID), autism spectrum disorders (ASD), attention deficit hyperactivity disorders (ADHD),
Johannes Lederbauer +6 more
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