Results 31 to 40 of about 99,329 (307)

Investigation of the guanine quadruplex resolving activity of the DEAH-box RNA helicase RHAU [PDF]

open access: yes, 2012
Generally depicted as single- or double-stranded molecules, nucleic acids sequences can adopt various forms of stable secondary structures. In particular, guanine-riche sequence of DNA and RNA can form atypical four-stranded helical structures termed G ...
Lattmann, Simon
core   +1 more source

Role reversal of functional identity in host factors: Dissecting features affecting pro-viral versus antiviral functions of cellular DEAD-box helicases in tombusvirus replication.

open access: yesPLoS Pathogens, 2020
Positive-stranded (+)RNA viruses greatly exploit host cells to support viral replication. However, unlike many other pathogens, (+)RNA viruses code for only a limited number of genes, making them highly dependent on numerous co-opted host factors for ...
Cheng-Yu Wu, Peter D Nagy
doaj   +1 more source

Methotrexate, an anti-inflammatory drug, inhibits Hepatitis E viral replication

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2023
Hepatitis E Virus (HEV) is a positively oriented RNA virus having a 7.2 kb genome. HEV consists of three open reading frames (ORF1-3). Of these, ORF1 codes for the enzymes Methyltransferase (Mtase), Papain-like cysteine protease (PCP), RNA helicase, and ...
Akash Kumar   +7 more
doaj   +1 more source

Structural basis of Zika virus helicase in recognizing its substrates

open access: yesProtein & Cell, 2016
The recent explosive outbreak of Zika virus (ZIKV) infection has been reported in South and Central America and the Caribbean. Neonatal microcephaly associated with ZIKV infection has already caused a public health emergency of international concern.
Hongliang Tian   +14 more
doaj   +1 more source

The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster. [PDF]

open access: yes, 2011
Gene expression is highly dynamic and many genes show a wide range in expression over several orders of magnitude. This regulation is often mediated by sequence specific transcription factors.
Bag, I.   +32 more
core   +1 more source

Coordinated function of cellular DEAD-box helicases in suppression of viral RNA recombination and maintenance of viral genome integrity. [PDF]

open access: yesPLoS Pathogens, 2015
The intricate interactions between viruses and hosts include an evolutionary arms race and adaptation that is facilitated by the ability of RNA viruses to evolve rapidly due to high frequency mutations and genetic RNA recombination.
Chingkai Chuang   +2 more
doaj   +1 more source

RNA helicase and colon cancer [PDF]

open access: yesCancer Biology & Therapy, 2008
Commentary to:Knockdown of RCK/p54 expression by RNAi inhibits proliferation of human colorectal cancer cells in vitro and in vivo Fang Lin, Rui Wang, Jian-Jun Shen, Xi Wang, Ping Gao, Ke Dong, Hui-Zhong ...
Jun, Zhang   +3 more
openaire   +2 more sources

Helicase binding to DnaI exposes a cryptic DNA-binding site during helicase loading in Bacillus subtilis [PDF]

open access: yes, 1981
The Bacillus subtilis DnaI, DnaB and DnaD proteins load the replicative ring helicase DnaC onto DNA during priming of DNA replication. Here we show that DnaI consists of a C-terminal domain (Cd) with ATPase and DNA-binding activities and an N-terminal ...
Shi, Wei   +999 more
core   +1 more source

RNA helicases in infection and disease [PDF]

open access: yesRNA Biology, 2012
RNA helicases unwind their RNA substrates in an ATP-dependent reaction, and are central to all cellular processes involving RNA. They have important roles in viral life cycles, where RNA helicases are either virus-encoded or recruited from the host. Vertebrate RNA helicases sense viral infections, and trigger the innate antiviral immune response.
Steimer Lenz, Klostermeier Dagmar
openaire   +2 more sources

Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication [PDF]

open access: yes, 2010
© The Author(s) 2010. Published by Oxford University PressGenome duplication requires accessory helicases to displace proteins ahead of advancing replication forks.
Lloyd, RG   +11 more
core   +1 more source

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