Results 41 to 50 of about 99,329 (307)

DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation. [PDF]

PLoS Pathogens, 2014
RIG-I is a DExD/H-box RNA helicase and functions as a critical cytoplasmic sensor for RNA viruses to initiate antiviral interferon (IFN) responses. Here we demonstrate that another DExD/H-box RNA helicase DHX36 is a key molecule for RIG-I signaling by ...
Ji-Seung Yoo, Kiyohiro Takahasi, Chen Seng Ng, Ryota Ouda, Koji Onomoto, Mitsutoshi Yoneyama, Janice Ching Lai, Simon Lattmann, Yoshikuni Nagamine, Tadashi Matsui, Kuniyoshi Iwabuchi, Hiroki Kato, Takashi Fujita   +12 more
doaj   +1 more source

ATPase cycle and DNA unwinding kinetics of RecG helicase [PDF]

, 2012
The superfamily 2 bacterial helicase, RecG, is a monomeric enzyme with a role in DNA repair by reversing stalled replication forks. The helicase must act specifically and rapidly to prevent replication fork collapse. We have shown that RecG binds tightly
Webb, Martin R, Powell, Ben, Ben Powell (159692), Toseland, Christopher P., Powell Ben, Webb Martin R., Toseland Christopher P., Martin R Webb, Christopher P Toseland, Ben Powell, Christopher P. Toseland (13866), Martin R. Webb (159695)   +11 more
core   +1 more source

RNA Strand Displacement Assay for Hepatitis E Virus Helicase

Bio-Protocol, 2017
The hepatitis E virus (HEV) helicase uses ATP to unwind the RNA duplexes. This is an essential step for viral replication. This protocol aims to measure the double strand RNA unwinding activity of the HEV helicase.
Vidya Nair, Milan Surjit
doaj   +1 more source

Structural basis for RNA-duplex unwinding by the DEAD-box helicase DbpA [PDF]

, 2023
DEAD-box RNA helicases are implicated in most aspects of RNA biology, where these enzymes unwind short RNA duplexes in an ATP-dependent manner. During the central step of the unwinding cycle, the two domains of the helicase core form a distinct closed ...
Wurm, Jan Philip
core   +1 more source

Human Enterovirus Nonstructural Protein 2CATPase Functions as Both an RNA Helicase and ATP-Independent RNA Chaperone.

PLoS Pathogens, 2015
RNA helicases and chaperones are the two major classes of RNA remodeling proteins, which function to remodel RNA structures and/or RNA-protein interactions, and are required for all aspects of RNA metabolism.
Hongjie Xia, Peipei Wang, Guang-Chuan Wang, Jie Yang, Xianlin Sun, Wenzhe Wu, Yang Qiu, Ting Shu, Xiaolu Zhao, Lei Yin, Cheng-Feng Qin, Yuanyang Hu, Xi Zhou   +12 more
doaj   +1 more source

Roles of the linker region of RNA helicase A in HIV-1 RNA metabolism. [PDF]

PLoS ONE, 2013
RNA helicase A (RHA) promotes multiple steps in HIV-1 production including transcription and translation of viral RNA, annealing of primer tRNA(Lys3) to viral RNA, and elevating the ratio of unspliced to spliced viral RNA.
Li Xing, Meijuan Niu, Xia Zhao, Lawrence Kleiman   +3 more
doaj   +1 more source

A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance

mBio, 2023
Coronaviruses (CoVs) encode nonstructural proteins 1–16 (nsps 1–16) which form replicase complexes that mediate viral RNA synthesis. Remdesivir (RDV) is an adenosine nucleoside analog antiviral that inhibits CoV RNA synthesis.
Samantha L. Grimes, Young J. Choi, Anoosha Banerjee, Gabriel Small, Jordan Anderson-Daniels, Jennifer Gribble, Andrea J. Pruijssers, Maria L. Agostini, Alexandra Abu-Shmais, Xiaotao Lu, Seth A. Darst, Elizabeth Campbell, Mark R. Denison   +12 more
doaj   +1 more source

The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription. [PDF]

PLoS ONE, 2016
RNA helicase family members exhibit diverse cellular functions, including in transcription, pre-mRNA processing, RNA decay, ribosome biogenesis, RNA export and translation.
Nian Xiang, Miao He, Musarat Ishaq, Yu Gao, Feifei Song, Liang Guo, Li Ma, Guihong Sun, Dan Liu, Deyin Guo, Yu Chen   +10 more
doaj   +1 more source

Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera

, 2013
DEAD box helicases catalyze the ATP-dependent destabilization of RNA duplexes. Whereas duplex separation is mediated by the helicase core shared by all members of the family, flanking domains often contribute to binding of the RNA substrate.
Wöhnert, Jens, Linden, Martin H., Rudolph, Markus G., Steimer, Lenz, Wurm, Jan Philip, Klostermeier, Dagmar   +5 more
core   +1 more source

Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12

Brazilian Journal of Medical and Biological Research, 2001
DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension
A.A. Camargo, D.N. Nunes, H.B. Samaia, L. Liu, V.P. Collins, A.J.G. Simpson, E. Dias-Neto   +6 more
doaj   +1 more source