Results 61 to 70 of about 99,329 (307)

The Sole DEAD-Box RNA Helicase of the Gastric Pathogen Helicobacter pylori Is Essential for Colonization

mBio, 2018
Present in every kingdom of life, generally in multiple copies, DEAD-box RNA helicases are specialized enzymes that unwind RNA secondary structures. They play major roles in mRNA decay, ribosome biogenesis, and adaptation to cold temperatures.
Lamya El Mortaji, Sylvie Aubert, Eloïse Galtier, Christine Schmitt, Karine Anger, Yulia Redko, Yves Quentin, Hilde De Reuse   +7 more
doaj   +1 more source

The RNA helicase A in malignant transformation

Oncotarget, 2016
The RNA helicase A (RHA) is involved in several steps of RNA metabolism, such as RNA processing, cellular transit of viral molecules, ribosome assembly, regulation of transcription and translation of specific mRNAs. RHA is a multifunctional protein whose roles depend on the specific interaction with different molecular partners, which have been ...
Fidaleo M., De Paola E., Paronetto M. P.
openaire   +4 more sources

RNA Helicases on the Move [PDF]

Biophysical Journal, 2014
We have investigated the mechanical properties of the RNA-helicase-motor proteins in single-molecule assays using Magnetic Tweezers. RNA helicases are fundamental molecular motors that remodel RNA structures, DNA/RNA hybrids and RNA-protein complexes that are essential in gene regulation.
Saurabh, Raj, Bagchi, Debjiani, Fiorini, Francesca, Le Hir, Hervé, Tanner, Kyle, Banroques, Josette, Croquette, Vincent   +6 more
openaire   +1 more source

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]

, 2010
For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Andrzej Dziembowski, Rafal Tomecki, Tomecki, Rafał, Dziembowski, Andrzej   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Oxysterol binding protein (OSBP) contributes to hepatitis E virus replication

Virology Journal
Hepatitis E virus (HEV) is a positive-sense, single-stranded RNA virus and causes primarily acute self-limiting infections. The ORF1 of the HEV genome encodes a polyprotein around 190 kDa, which contains several putative domains, including helicase and ...
Shaoli Lin, Peixi Chang, Shane Tsao, Abigail Aderinwale, Bhargava Teja Sallapalli, Jia He, Yanjin Zhang   +6 more
doaj   +1 more source

Computational design, docking, and molecular dynamics simulation study of RNA helicase inhibitors of dengue virus

Journal of Vector Borne Diseases
Background & objectives: RNA viruses are complex pathogens in terms of their genetic makeup, mutation frequency, and transmission modes. They contain the RNA helicase enzyme, which plays a crucial role in the viral genome replication process.
Raghunath Satpathy, Sonali Acharya, Rashmiranjan Behera   +2 more
doaj   +1 more source

Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing [PDF]

Nucleic Acids Research, 2014
Helicases contribute to diverse biological processes including replication, transcription and translation. Recent reports suggest that unwinding of some helicases display repetitive activity, yet the functional role of the repetitiveness requires further investigation.
Koh, Hye Ran, Xing, Li, Kleiman, Lawrence, Myong, Sua   +3 more
openaire   +2 more sources

Xp54 and related (DDX6-like) RNA helicases : roles in messenger RNP assembly, translation regulation and RNA degradation

, 2006
The DEAD-box RNA helicase Xp54 is an integral component of the messenger ribonucleoprotein (mRNP) particles of Xenopus oocytes. In oocytes, several abundant proteins bind pre-mRNA transcripts to modulate nuclear export, RNA stability and translational ...
Weston, A, Sommerville, John
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source