Results 21 to 30 of about 1,397,424 (256)
DEAD-box RNA helicases in Escherichia coli [PDF]
Nucleic Acids Research, 2006 In spite of their importance in RNA metabolism, the function of DExD/H-box proteins (including DEAD-box proteins) is poorly understood at the molecular level. Here, we present recent progress achieved with the five DEAD-box proteins from Escherichia coli, which have been particularly well studied. These proteins, which have orthologues in many bacteria,
Iost I, *, Dreyfus, M.
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Frontiers in Oncology, 2021 The major obstacle to treat cervical squamous cell carcinoma (CSCC) is the high prevalence of metastasis, which severely affects 5-year survival rate and quality of life for cancer patients. The DEAD-box helicase family has been reported to be a critical
Yanhui Jiang +16 more
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DEAD-box helicases: Posttranslational regulation and function [PDF]
Biochemical and Biophysical Research Communications, 2010 Helicases are enzymes that can separate duplex oligonucleotides in a NTP-dependent fashion and are essential in all aspects of DNA and RNA metabolism. Amino acid sequence analysis identified several conserved sequence motifs in DNA and RNA helicases allowing their classification into 5 major groups (Super families SF1–SF5) [1].
Eric A, Gustafson, Gary M, Wessel
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DEAD‐box proteins as RNA helicases and chaperones [PDF]
WIREs RNA, 2010 AbstractDEAD‐box proteins are ubiquitous in RNA‐mediated processes and function by coupling cycles of ATP binding and hydrolysis to changes in affinity for single‐stranded RNA. Many DEAD‐box proteins use this basic mechanism as the foundation for a version of RNA helicase activity, efficiently separating the strands of short RNA duplexes in a process ...
Inga, Jarmoskaite, Rick, Russell
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Frontiers in Plant Science, 2021 DEAD-box RNA helicases constitute the largest subfamily of RNA helicase superfamily 2 (SF2), and play crucial roles in plant growth, development, and abiotic stress responses.
Jing-Na Ru +11 more
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Genome-wide comparative in silico analysis of the RNA helicase gene family in Zea mays and Glycine max: a comparison with Arabidopsis and Oryza sativa. [PDF]
PLoS ONE, 2013 RNA helicases are enzymes that are thought to unwind double-stranded RNA molecules in an energy-dependent fashion through the hydrolysis of NTP. RNA helicases are associated with all processes involving RNA molecules, including nuclear transcription ...
Ruirui Xu +3 more
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Tho1 and MOS11 promote nucleic acid double-strand unwinding by facilitating DEAD-box helicase oligomerization. [PDF]
Nucleic Acids ResDEAD-box helicases are essential for gene expression and RNA metabolism. However, the mechanisms regulating their activity remain largely elusive. The DEAD-box helicase DDX39B/UAP56 forms a 2:1 complex with the C-terminal domain (CTD) of RNA-binding ...
Becker F +6 more
europepmc +2 more sources
DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense
Viruses, 2020 DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family have roles throughout cellular RNA metabolism from biogenesis to decay ...
Frances Taschuk, Sara Cherry
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DEAD Box Helicases in Rnp Granule [PDF]
Biophysical Journal, 2014 Processing body (p-body) granule is located at the cytoplasm of eukaryotic cells and serves as a molecular hub for collection of mRNA and RNA processing enzymes. (Science 324 pg. 26 June 2009) P-body has been implicated for mRNA storage, splicing, degradation and translational repression, but how it assembles and carries out the diverse array of ...
Kim, Younghoon +3 more
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Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera [PDF]
, 2013 DEAD box helicases catalyze the ATP-dependent destabilization of RNA duplexes. Whereas duplex separation is mediated by the helicase core shared by all members of the family, flanking domains often contribute to binding of the RNA substrate.
Wöhnert, Jens +5 more
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