The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X [PDF]
Nature Communications, 2019 DEAD-box helicases (DDXs) function in an ATP-dependent, non-processive manner and the conserved helicase core is composed of two RecA-like domains D1 and D2.
He Song, Xinhua Ji
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DEAD-box Helicase 27 Promotes Hepatocellular Carcinoma Progression Through ERK Signaling [PDF]
Technology in Cancer Research & Treatment, 2021 Introduction: DEAD-box helicase 27 (DDX27) belongs to DEAD-Box nucleic acid helicase family. The function of DDX27 in hepatocellular carcinoma (HCC) remain enigmatic.
Wang Xiaoqian +10 more
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Architectures of the unique domains associated with the DEAD-box helicase motif [PDF]
Cell Cycle, 2010 Helicases are motor proteins of biological system, which catalyze the opening of energetically stable duplex nucleic acids in an ATP-dependent manner and thereby are involved in almost all aspects of nucleic acid metabolism including cell cycle ...
Tuteja , Renu +3 more
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Investigations of the DEAD-box helicase eIF4A [PDF]
, 2011 Eukaryotic Initiation Factor (eIF) 4A is the most abundant initiation factor and the prototypical member of the DEAD-box family of helicases. Once recruited to the cap-binding complex, eIF4F, eIF4A unwinds inhibitory RNA secondary structure in the 5 ...
Phillips, Nicola Marie
core +3 more sources
‘DEAD-box’ helicase from Plasmodium falciparum is active at wide pH and is schizont stage-specific [PDF]
Journal of Vector Borne Diseases, 2007 Background & objectives: DNA helicases catalyse unwinding of duplex DNA in an ATP-dependentmanner and are involved in all the basic genetic processes.
Arun Pradhan, +2 more
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DEAD-Box RNA Helicases and Genome Stability [PDF]
Genes, 2021 DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome. Current studies have provided insight into the connection between genomic stability and several DEAD-box ...
Michael Cargill +2 more
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Multifunctional role of DEAD-box helicase 41 in innate immunity, hematopoiesis and disease [PDF]
Frontiers in ImmunologySusan R Ross, Ross Susan R
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The emerging role of DEAD/H-box helicases in hepatitis B virus infection
Frontiers in Cellular and Infection Microbiology, 2022 DEAD/H-box helicases are an essential protein family with a conserved motif containing unique amino acid sequences (Asp-Glu-Ala-Asp/His). Current evidence indicates that DEAD/H-box helicases regulate RNA metabolism and innate immune responses.
Hongjuan You +11 more
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Structural basis for RNA-duplex unwinding by the DEAD-box helicase DbpA. [PDF]
RNA, 2023 DEAD-box RNA helicases are implicated in most aspects of RNA biology, where these enzymes unwind short RNA duplexes in an ATP-dependent manner. During the central step of the unwinding cycle, the two domains of the helicase core form a distinct closed ...
Wurm JP.
europepmc +2 more sources
AMP Sensing by DEAD-Box RNA Helicases [PDF]
Journal of Molecular Biology, 2013 In eukaryotes, cellular levels of adenosine monophosphate (AMP) signal the metabolic state of the cell. AMP concentrations increase significantly upon metabolic stress, such as glucose deprivation in yeast. Here, we show that several DEAD-box RNA helicases are sensitive to AMP, which is not produced during ATP hydrolysis by these enzymes.
Andrea A, Putnam, Eckhard, Jankowsky
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