Results 31 to 40 of about 20,358 (251)
DEAD-box helicases: Posttranslational regulation and function [PDF]
Biochemical and Biophysical Research Communications, 2010 Helicases are enzymes that can separate duplex oligonucleotides in a NTP-dependent fashion and are essential in all aspects of DNA and RNA metabolism. Amino acid sequence analysis identified several conserved sequence motifs in DNA and RNA helicases allowing their classification into 5 major groups (Super families SF1–SF5) [1].
Eric A, Gustafson, Gary M, Wessel
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DEAD-box RNA helicases in Escherichia coli [PDF]
Nucleic Acids Research, 2006 In spite of their importance in RNA metabolism, the function of DExD/H-box proteins (including DEAD-box proteins) is poorly understood at the molecular level. Here, we present recent progress achieved with the five DEAD-box proteins from Escherichia coli, which have been particularly well studied. These proteins, which have orthologues in many bacteria,
Iost, Isabelle, Dreyfus, Marc
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Wait and capture: unwinding the strategy of a DEAD-box helicase. [PDF]
PLoS Biology, 2014 RNA plays a wide variety of roles in every cell, from structural to informational to catalytic. That variety depends in large part on its ability to adopt a three-dimensional conformation suited to each application, often in tight association with protein or other polynucleotides.
Richard Robinson
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DEAD‐box proteins as RNA helicases and chaperones [PDF]
WIREs RNA, 2010 AbstractDEAD‐box proteins are ubiquitous in RNA‐mediated processes and function by coupling cycles of ATP binding and hydrolysis to changes in affinity for single‐stranded RNA. Many DEAD‐box proteins use this basic mechanism as the foundation for a version of RNA helicase activity, efficiently separating the strands of short RNA duplexes in a process ...
Inga, Jarmoskaite, Rick, Russell
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DEAD Box Helicases in Rnp Granule [PDF]
Biophysical Journal, 2014 Processing body (p-body) granule is located at the cytoplasm of eukaryotic cells and serves as a molecular hub for collection of mRNA and RNA processing enzymes. (Science 324 pg. 26 June 2009) P-body has been implicated for mRNA storage, splicing, degradation and translational repression, but how it assembles and carries out the diverse array of ...
Kim, Younghoon +3 more
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Domain orientation in the RNA helicase YxiN and the role of conformational changes for RNA unwinding [PDF]
, 2010 The RNA helicase YxiN from Bacillus subtilis is a member of the family of DEAD box proteins. YxiN is able to unwind RNA double strands in an ATP-dependent manner. The ability to catalyse RNA rearrangement is in vivo presumably necessary for the bacterial
Karow, Anne R.
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The DEAD box RNA helicase family in Arabidopsis thaliana [PDF]
Nucleic Acids Research, 1999 The numerous genomic sequences and ESTs released by the Arabidopsis thaliana Genome Initiative (AGI) have allowed a systematic and functional study of the DEAD box RNA helicase family. Sequencing and in silico analysis led to the characterization of 28 novel A. thaliana DEAD box RNA helicases forming a family of 32 members, named AtRH.
Aubourg, Sébastien +2 more
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Investigation of the guanine quadruplex resolving activity of the DEAH-box RNA helicase RHAU [PDF]
, 2012 Generally depicted as single- or double-stranded molecules, nucleic acids sequences can adopt various forms of stable secondary structures. In particular, guanine-riche sequence of DNA and RNA can form atypical four-stranded helical structures termed G ...
Lattmann, Simon
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ATPase cycle and DNA unwinding kinetics of RecG helicase [PDF]
, 2012 The superfamily 2 bacterial helicase, RecG, is a monomeric enzyme with a role in DNA repair by reversing stalled replication forks. The helicase must act specifically and rapidly to prevent replication fork collapse. We have shown that RecG binds tightly
Webb, Martin R +11 more
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The Ded1 DEAD Box Helicase Interacts with Chk1 and Cdc2 [PDF]
Journal of Biological Chemistry, 2002 Ded1 is a fission yeast DEAD box protein involved in translation. We isolated Ded1 in a screen for multi-copy suppressors of a cold-sensitive, loss-of-function mutant of the cyclin-dependent kinase Cdc2. The checkpoint protein kinase Chk1, required for cell cycle arrest in response to DNA damage, was also isolated in this screen.
Hsing-Yin, Liu +2 more
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