Results 31 to 40 of about 1,397,424 (256)
A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication [PDF]
, 2011 DEAD-box proteins are enzymes endowed with nucleic acid-dependent ATPase, RNA translocase and unwinding activities. The human DEAD-box protein DDX3 has been shown to play important roles in tumor proliferation and viral infections.
Di Cicco, Giulia +9 more
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PLoS Pathogens, 2020 Positive-stranded (+)RNA viruses greatly exploit host cells to support viral replication. However, unlike many other pathogens, (+)RNA viruses code for only a limited number of genes, making them highly dependent on numerous co-opted host factors for ...
Cheng-Yu Wu, Peter D Nagy
doaj +1 more source
Unraveling the ‘DEAD-box’ helicases of Plasmodium falciparum
Gene, 2006 The causative agent for the most fatal form of malaria, Plasmodium falciparum, has developed insecticide and drug resistance with time. Therefore combating this disease is becoming increasingly difficult and this calls for finding alternate ways to control malaria.
Tuteja, Renu, Pradhan, Arun
openaire +2 more sources
The DEAD box RNA helicase family in Arabidopsis thaliana [PDF]
Nucleic Acids Research, 1999 The numerous genomic sequences and ESTs released by the Arabidopsis thaliana Genome Initiative (AGI) have allowed a systematic and functional study of the DEAD box RNA helicase family. Sequencing and in silico analysis led to the characterization of 28 novel A. thaliana DEAD box RNA helicases forming a family of 32 members, named AtRH.
Aubourg, Sébastien +2 more
openaire +3 more sources
Domain orientation in the RNA helicase YxiN and the role of conformational changes for RNA unwinding [PDF]
, 2010 The RNA helicase YxiN from Bacillus subtilis is a member of the family of DEAD box proteins. YxiN is able to unwind RNA double strands in an ATP-dependent manner. The ability to catalyse RNA rearrangement is in vivo presumably necessary for the bacterial
Karow, Anne R.
core +1 more source
Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12
Brazilian Journal of Medical and Biological Research, 2001 DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension
A.A. Camargo +6 more
doaj +1 more source
Allosteric activation of RhlB by RNase E induces partial duplex opening in substrate RNA
Frontiers in Molecular Biosciences, 2023 The E. coli DEAD-Box helicase RhlB is responsible for ATP-dependent unwinding of structured mRNA to facilitate RNA degradation by the protein complex degradosome.
Heidi Zetzsche +2 more
doaj +1 more source
ATPase cycle and DNA unwinding kinetics of RecG helicase [PDF]
, 2012 The superfamily 2 bacterial helicase, RecG, is a monomeric enzyme with a role in DNA repair by reversing stalled replication forks. The helicase must act specifically and rapidly to prevent replication fork collapse. We have shown that RecG binds tightly
Webb, Martin R +11 more
core +1 more source
The DDX5/Dbp2 subfamily of DEAD‐box RNA helicases [PDF]
WIREs RNA, 2018 The mammalian DEAD‐box RNA helicase DDX5, its paralog DDX17, and their orthologs in Saccharomyces cerevisiae and Drosophila melanogaster, namely Dbp2 and Rm62, define a subfamily of DEAD‐box proteins. Members from this subfamily share highly conserved protein sequences and cellular functions.
Zheng, Xing +2 more
openaire +2 more sources
Investigation of the guanine quadruplex resolving activity of the DEAH-box RNA helicase RHAU [PDF]
, 2012 Generally depicted as single- or double-stranded molecules, nucleic acids sequences can adopt various forms of stable secondary structures. In particular, guanine-riche sequence of DNA and RNA can form atypical four-stranded helical structures termed G ...
Lattmann, Simon
core +1 more source