Results 31 to 40 of about 34,246 (233)

Multifunctional role of DEAD-box helicase 41 in innate immunity, hematopoiesis and disease. [PDF]

Front Immunol
Ma J, Ross SR.
europepmc   +2 more sources

DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure. [PDF]

Signal Transduct Target Ther
Yan M, Gao J, Lan M, Wang Q, Cao Y, Zheng Y, Yang Y, Li W, Yu X, Huang X, Dou L, Liu B, Liu J, Cheng H, Ouyang K, Xu K, Sun S, Liu J, Tang W, Zhang X, Man Y, Sun L, Cai J, He Q, Tang F, Li J, Shen T.   +26 more
europepmc   +2 more sources

DEAD‐box proteins as RNA helicases and chaperones [PDF]

WIREs RNA, 2010
AbstractDEAD‐box proteins are ubiquitous in RNA‐mediated processes and function by coupling cycles of ATP binding and hydrolysis to changes in affinity for single‐stranded RNA. Many DEAD‐box proteins use this basic mechanism as the foundation for a version of RNA helicase activity, efficiently separating the strands of short RNA duplexes in a process ...
Inga, Jarmoskaite, Rick, Russell
openaire   +2 more sources

Genome-wide comparative in silico analysis of the RNA helicase gene family in Zea mays and Glycine max: a comparison with Arabidopsis and Oryza sativa. [PDF]

PLoS ONE, 2013
RNA helicases are enzymes that are thought to unwind double-stranded RNA molecules in an energy-dependent fashion through the hydrolysis of NTP. RNA helicases are associated with all processes involving RNA molecules, including nuclear transcription ...
Ruirui Xu, Shizhong Zhang, Jinguang Huang, Chengchao Zheng   +3 more
doaj   +1 more source

Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera [PDF]

, 2013
DEAD box helicases catalyze the ATP-dependent destabilization of RNA duplexes. Whereas duplex separation is mediated by the helicase core shared by all members of the family, flanking domains often contribute to binding of the RNA substrate.
Klostermeier, Dagmar, Linden, Martin H., Rudolph, Markus G., Steimer, Lenz, Wurm, Jan Philip, Wöhnert, Jens   +5 more
core   +1 more source

Role reversal of functional identity in host factors: Dissecting features affecting pro-viral versus antiviral functions of cellular DEAD-box helicases in tombusvirus replication.

PLoS Pathogens, 2020
Positive-stranded (+)RNA viruses greatly exploit host cells to support viral replication. However, unlike many other pathogens, (+)RNA viruses code for only a limited number of genes, making them highly dependent on numerous co-opted host factors for ...
Cheng-Yu Wu, Peter D Nagy
doaj   +1 more source

Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12

Brazilian Journal of Medical and Biological Research, 2001
DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension
A.A. Camargo, D.N. Nunes, H.B. Samaia, L. Liu, V.P. Collins, A.J.G. Simpson, E. Dias-Neto   +6 more
doaj   +1 more source

Allosteric activation of RhlB by RNase E induces partial duplex opening in substrate RNA

Frontiers in Molecular Biosciences, 2023
The E. coli DEAD-Box helicase RhlB is responsible for ATP-dependent unwinding of structured mRNA to facilitate RNA degradation by the protein complex degradosome.
Heidi Zetzsche, Laura Raschke, Boris Fürtig   +2 more
doaj   +1 more source

Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase [PDF]

, 2008
In yeast, three small nucleolar RNAs (snoRNAs) are essential for the processing of pre-ribosomal RNA—U3, U14 and snR30—whereas 72 non-essential snoRNAs direct site-specific modification of pre-rRNA. We applied a quantitative screen for alterations in the
Bohnsack, Markus, Kos, Martin, Tollervey, David   +2 more
core   +2 more sources

A loss-of-function homozygous mutation in DDX59 implicates a conserved DEAD-box RNA helicase in nervous system development and function. [PDF]

, 2017
We report on a homozygous frameshift deletion in DDX59 (c.185del: p.Phe62fs*13) in a family presenting with orofaciodigital syndrome phenotype associated with a broad neurological involvement characterized by microcephaly, intellectual disability ...
Ashokkumar, B, Bello, OD, Bettencourt, C, Botia, JA, Cutrupi, MC, Dipasquale, V, Efthymiou, S, Houlden, H, Mankad, K, Manole, A, Manti, S, Maurya, B, Mukherjee, A, Mutsuddi, M, Ryten, M, Salpietro, V, Vandrovcova, J, Wiethoff, S   +17 more
core   +1 more source