Coordinated function of cellular DEAD-box helicases in suppression of viral RNA recombination and maintenance of viral genome integrity. [PDF]
PLoS Pathogens, 2015 The intricate interactions between viruses and hosts include an evolutionary arms race and adaptation that is facilitated by the ability of RNA viruses to evolve rapidly due to high frequency mutations and genetic RNA recombination.
Chingkai Chuang +2 more
doaj +1 more source
ATPase mechanism of the 5'-3' DNA helicase, RecD2: evidence for a pre-hydrolysis conformation change [PDF]
, 2013 The superfamily 1 helicase, RecD2, is a monomeric, bacterial enzyme with a role in DNA repair, but with 5'-3' activity unlike most enzymes from this superfamily. Rate constants were determined for steps within the ATPase cycle of RecD2 in the presence of
Webb, Martin R, Toseland, Christopher P.
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The DDX5/Dbp2 subfamily of DEAD‐box RNA helicases [PDF]
WIREs RNA, 2018 The mammalian DEAD‐box RNA helicase DDX5, its paralog DDX17, and their orthologs in Saccharomyces cerevisiae and Drosophila melanogaster, namely Dbp2 and Rm62, define a subfamily of DEAD‐box proteins. Members from this subfamily share highly conserved protein sequences and cellular functions.
Zheng, Xing +2 more
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Long-range conformational changes in the nucleotide-bound states of the DEAD-box helicase Vasa. [PDF]
Biophys JDEAD-box helicases use ATP to unwind short double-stranded RNA (dsRNA). The helicase core consists of two discrete domains, termed RecA_N and RecA_C.
Codutti L +3 more
europepmc +2 more sources
Die DEAD-box Helikase Hera aus "Thermus thermophilus". Untersuchung der Wechselwirkung mit Nukleinsäuren und der Helikaseaktivität [PDF]
, 2009 Hera ist eine DEAD-Box Helikase aus Thermus thermophilus. Wie bei vielen anderen DEADbox Helikasen auch, ist wenig über die physiologische Rolle von Hera bekannt.
Linden, Martin Hubert
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Unraveling the ‘DEAD-box’ helicases of Plasmodium falciparum
Gene, 2006 The causative agent for the most fatal form of malaria, Plasmodium falciparum, has developed insecticide and drug resistance with time. Therefore combating this disease is becoming increasingly difficult and this calls for finding alternate ways to control malaria.
Tuteja, Renu, Pradhan, Arun
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Bacterial versatility requires DEAD-box RNA helicases [PDF]
FEMS Microbiology Reviews, 2015 RNA helicases of the DEAD-box and DEAH-box families are important players in many processes involving RNA molecules. These proteins can modify RNA secondary structures or intermolecular RNA interactions and modulate RNA-protein complexes. In bacteria, they are known to be involved in ribosome biogenesis, RNA turnover and translation initiation.
Redder P. +4 more
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Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy
Frontiers in Oncology, 2023 DEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including transcription, pre-mRNA splicing, ribosomes biogenesis, nuclear export, translation initiation, RNA degradation, and mRNA editing.
Ananna Bhadra Arna +7 more
doaj +1 more source
Biological roles of DExH RNA helicase, RHAU [PDF]
, 2007 In this thesis, I have described the work carried out on a single protein called RHAU, dealing with aspects of protein localization in cells, the regulation of global gene expression by different mechanisms, and cellular stress-responses.
Iwamoto, Fumiko
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PLoS ONE, 2019 Yersinia pseudotuberculosis is an important foodborne pathogen threatening modern food safety due to its ability to survive and grow at low temperatures. DEAD-box RNA helicase CsdA has been shown to play an important role in the low-temperature growth of
Xiaojie Jiang +3 more
doaj +1 more source