Results 51 to 60 of about 1,397,424 (256)
Snf2 family ATPases and DExx box helicases:differences and unifying concepts from high-resolution crystal structures [PDF]
, 2006 Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA-protein structures including chromatin. Snf2 family enzymes are related in sequence to DExx box helicases,
Owen-Hughes, Tom; id_orcid +3 more
core +1 more source
Comparative structural analysis of human DEAD-box RNA helicases. [PDF]
PLoS ONE, 2010 DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections.
Patrick Schütz +12 more
doaj +1 more source
Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells [PDF]
, 2011 DEAD box protein, DDX3, is aberrantly expressed in breast cancer cells ranging from weakly invasive to aggressive phenotypes and functions as an important regulator of cancer cell growth and survival.
Krishnamachary, B. +16 more
core +1 more source
Frontiers in Oncology, 2021 Ovarian carcinoma remains the most lethal gynecological carcinoma. Abnormal expression of splicing factors is closely related to the occurrence and development of tumors.
Chen Zhao +17 more
doaj +1 more source
Bacterial versatility requires DEAD-box RNA helicases [PDF]
FEMS Microbiology Reviews, 2015 RNA helicases of the DEAD-box and DEAH-box families are important players in many processes involving RNA molecules. These proteins can modify RNA secondary structures or intermolecular RNA interactions and modulate RNA-protein complexes. In bacteria, they are known to be involved in ribosome biogenesis, RNA turnover and translation initiation.
Redder P. +4 more
openaire +4 more sources
Characterisation of XPD from Sulfolobus acidocaldarius : an iron-sulphur cluster containing DNA repair helicase [PDF]
, 2007 DNA is constantly damaged by a variety of exogenous and endogenous sources. To maintain the integrity of the genome, different DNA repair mechanisms have evolved, which deal with different kinds of DNA damage.
Rudolf, Jana
core +2 more sources
eLife, 2014 How different helicase families with a conserved catalytic ‘helicase core’ evolved to function on varied RNA and DNA substrates by diverse mechanisms remains unclear.
Anna L Mallam +2 more
doaj +1 more source
Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates
Scientific Reports, 2023 Inhibition of eukaryotic initiation factor 4A has been proposed as a strategy to fight pathogens. Rocaglates exhibit the highest specificities among eIF4A inhibitors, but their anti-pathogenic potential has not been comprehensively assessed across ...
Wiebke Obermann +22 more
doaj +1 more source
Factor-dependent processivity in human eIF4A DEAD-box helicase [PDF]
, 2015 During eukaryotic translation initiation, the small ribosomal subunit, assisted by initiation factors, locates the messenger RNA start codon by scanning from the 5' cap.
Feoktistova, Kateryna +4 more
core +1 more source
RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis
Cell Reports, 2019 Summary: DDX17, a DEAD-box ATPase, is a multifunctional helicase important for various RNA functions, including microRNA maturation. Key questions for DDX17 include how it recognizes target RNAs and influences their structures, as well as how its ATPase ...
Tri D. Ngo +2 more
doaj +1 more source