Results 71 to 80 of about 20,358 (251)

The DEAD-box RNA helicase RhlB is required for efficient RNA processing at low temperature in Caulobacter

Microbiology Spectrum, 2023
The RNA helicases from the DEAD-box family participate in several biochemical processes, with special relevance in the assembly of ribosome ribonucleoparticles and in RNA turnover as part of the multi-enzymatic RNA degradosome complex.
Hugo L. de Araújo, Beatriz A. Picinato, Alan P. R. Lorenzetti, Nisansala S. Muthunayake, I. W. Rathnayaka-Mudiyanselage, Naara M. dos Santos, Jared Schrader, Tie Koide, Marilis V. Marques   +8 more
doaj   +1 more source

Division of Labor in an Oligomer of the DEAD-Box RNA Helicase Ded1p [PDF]

Molecular Cell, 2015
Most aspects of RNA metabolism involve DEAD-box RNA helicases, enzymes that bind and remodel RNA and RNA-protein complexes in an ATP-dependent manner. Here we show that the DEAD-box helicase Ded1p oligomerizes in the cell and in vitro, and unwinds RNA as a trimer. Two protomers bind the single-stranded region of RNA substrates and load a third protomer
Putnam, Andrea A., Gao, Zhaofeng, Liu, Fei, Jia, Huijue, Yang, Quansheng, Jankowsky, Eckhard   +5 more
openaire   +2 more sources

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

DEAD-box helicases as integrators of RNA, nucleotide and protein binding [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
DEAD-box helicases perform diverse cellular functions in virtually all steps of RNA metabolism from Bacteria to Humans. Although DEAD-box helicases share a highly conserved core domain, the enzymes catalyze a wide range of biochemical reactions. In addition to the well established RNA unwinding and corresponding ATPase activities, DEAD-box helicases ...
Andrea A, Putnam, Eckhard, Jankowsky
openaire   +2 more sources

The advances of DEAD-box RNA helicase 17 in chronic non-infectious diseases

Frontiers in Cardiovascular Medicine
DEAD-box RNA helicase 17 (DDX17), a key member of the DEAD-box family, is vital in cellular physiological processes. This review summarizes its structural properties, distribution, functions, disease associations, and research trends. Structurally, DDX17
Mi Xiong, Qiang Wang, Ting Wang, Meiling Li, Xiangxiang Deng, Jia Wang, De Li, Yongjian Yang, Xiongshan Sun   +8 more
doaj   +1 more source

Metabolic Adaptation to Nutrients Involves Coregulation of Gene Expression by the RNA Helicase Dbp2 and the Cyc8 Corepressor in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2017
Cells fine-tune their metabolic programs according to nutrient availability in order to maintain homeostasis. This is achieved largely through integrating signaling pathways and the gene expression program, allowing cells to adapt to nutritional change ...
Siwen Wang, Zheng Xing, Pete E. Pascuzzi, Elizabeth J. Tran   +3 more
doaj   +1 more source

Heterogeneous dissociation process of truncated RNAs by oligomerized Vasa helicase

Communications Biology, 2021
Kinoshita et al. use single molecule imaging to show that the N-terminal extension of BmVasa, a germ-specific DEAD box RNA helicase, is necessary for protein oligomerization and the dissociation of target RNA from the Siwi-piRISC complex.
Yoshimi Kinoshita, Ryo Murakami, Nao Muto, Shintaroh Kubo, Ryo Iizuka, Sotaro Uemura   +5 more
doaj   +1 more source

A novel function for the DEAD-box RNA helicase DDX-23 in primary microRNA processing in Caenorhabditis elegans

, 2017
Primary microRNAs (pri-miRNAs) are cleaved by the nuclear RNase III Drosha to produce hairpin-shaped precursor miRNAs (pre-miRNAs). In humans, this process is known to be facilitated by the DEAD-box helicases p68 (DDX5) and p72 (DDX17). In this study, we
Chu, Yu-De;Chen, Hsin-Kai;Huang, Tao;Chan, Shih-Peng, 詹世鵬   +1 more
core   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin

Molecular & Cellular Oncology, 2021
In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair ...
Belen Gómez-González, Gaetana Sessa, Aura Carreira, Andrés Aguilera   +3 more
doaj   +1 more source