Results 91 to 100 of about 34,246 (233)
Advanced Science, EarlyView.RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu +7 more
wiley +1 more source
Targeting host DEAD-box RNA helicase DDX3X for treating viral infections
Antiviral Research, 2021 DDX3X or DDX3, a member of the DEAD (asp, glu, ala, asp) box RNA helicase family of proteins, is a multifunctional protein, which is usurped by several viruses and is vital to their production. To date, 18 species of virus from 12 genera have been demonstrated to be dependent on DDX3 for virulence.
Winnard Jr., Paul T. +2 more
openaire +2 more sources
The South American fruit fly : an important pest insect with RNAi-sensitive larval stages [PDF]
, 2019 RNA interference (RNAi) technology has been used in the development of approaches for pest control. The presence of some essential genes, the so-called "core genes," in the RNAi machinery is crucial for its efficiency and robust response in gene ...
Cagliari, Deise +6 more
core +1 more source
Animal Research and One Health, EarlyView.Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu +8 more
wiley +1 more source
To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]
, 2015 Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH +2 more
core +1 more source
BMEMat, EarlyView.Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu +13 more
wiley +1 more source
RNA chaperone activity of DEAD‐box ‘helicase’ proteins
The FASEB Journal, 2013 Cellular RNAs are able to fold to specific functional structures and carry out a host of critical processes despite an inherent propensity of RNA to fold to alternative conformations. In vivo , RNA misfolding is mitigated by RNA chaperones, notably DEAD‐box ‘helicase’ proteins. CYT‐19 is a
Rick Russell +2 more
openaire +1 more source
In vivo mapping of the functional regions of the DEAD-box helicase Vasa
Biology Open, 2015 The maternally expressed Drosophila melanogaster DEAD-box helicase Vasa (Vas) is necessary for many cellular and developmental processes, including specification of primordial germ cells (pole cells), posterior patterning of the embryo, piRNA-mediated ...
Mehrnoush Dehghani, Paul Lasko
doaj +1 more source
Omnipresent Maxwell’s demons orchestrate information management in living cells [PDF]
, 2019 The development of synthetic biology calls for accurate understanding of the critical functions that allow construction and operation of a living cell.
Danchin, Antoine +1 more
core
Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas. [PDF]
, 2020 MYC-driven lymphomas, especially those with concurrent MYC and BCL2 dysregulation, are currently a challenge in clinical practice due to rapid disease progression, resistance to standard chemotherapy, and high risk of refractory disease.
Bi, Chengfeng +15 more
core +1 more source