Results 101 to 110 of about 34,246 (233)
N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential
iNew Medicine, EarlyView.ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen +6 more
wiley +1 more source
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source
DEAD-box helicases as integrators of RNA, nucleotide and protein binding [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013 DEAD-box helicases perform diverse cellular functions in virtually all steps of RNA metabolism from Bacteria to Humans. Although DEAD-box helicases share a highly conserved core domain, the enzymes catalyze a wide range of biochemical reactions. In addition to the well established RNA unwinding and corresponding ATPase activities, DEAD-box helicases ...
Andrea A, Putnam, Eckhard, Jankowsky
openaire +2 more sources
Plasmodium falciparum DDX31 is DNA helicase localized in nucleolus
Heliyon, 2019 Malaria is a major infectious disease and is responsible for millions of infections every year. As drug resistance strains of Plasmodium species are emerging, there is an urgent need to understand the parasite biology and identify new drug targets ...
Rahena Yasmin +3 more
doaj +1 more source
Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop [PDF]
, 2017 DEAD-box proteins disrupt or remodel RNA and protein/RNA complexes at the expense of ATP. The catalytic core is composed of two flexibly connected RecA-like domains.
Diederichsen, Ulf +4 more
core
The ATPase cycle of PcrA helicase and its coupling to translocation on DNA. [PDF]
, 2009 The superfamily 1 bacterial helicase PcrA has a role in the replication of certain plasmids, acting with the initiator protein (RepD) that binds to and nicks the double-stranded origin of replication.
Martinez-Senac, Maria M +3 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu +4 more
wiley +1 more source
Coupling between the DEAD-box RNA helicases Ded1p and eIF4A
eLife, 2016 Eukaryotic translation initiation involves two conserved DEAD-box RNA helicases, eIF4A and Ded1p. Here we show that S. cerevisiae eIF4A and Ded1p directly interact with each other and simultaneously with the scaffolding protein eIF4G. We delineate a comprehensive thermodynamic framework for the interactions between Ded1p, eIF4A, eIF4G, RNA and ATP ...
Zhaofeng Gao +7 more
openaire +3 more sources
Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies
Genes and DiseasesHematopoiesis represents a meticulously regulated and dynamic biological process. Genetic aberrations affecting blood cells, induced by various factors, frequently give rise to hematological tumors. These instances are often accompanied by a multitude of
Jiankun Fan, Zhigang Li, Li Pei, Yu Hou
doaj +1 more source
‘DEAD-box’ helicase from Plasmodium falciparum is active at wide pH and is schizont stage-specific [PDF]
Journal of Vector Borne Diseases, 2007 Background & objectives: DNA helicases catalyse unwinding of duplex DNA in an ATP-dependentmanner and are involved in all the basic genetic processes.
Arun Pradhan, +2 more
doaj