Results 71 to 80 of about 1,216 (256)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Sensors, 2016 A high-performance differential global positioning system (GPS) receiver with real time kinematics provides absolute localization for driverless cars. However, it is not only susceptible to multipath effect but also unable to effectively fulfill precise
Shiyao Wang, Zhidong Deng, Gang Yin
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A Low-Cost Underground Garage Navigation Switching Algorithm Based on Kalman Filtering
Sensors, 2019 Modern parking lots have gradually developed into underground garages to improve the efficient use of space. However, the complex design of parking lots also increases the demands on vehicle navigation. The traditional method of navigation switching only
Ningbo Li +5 more
doaj +1 more source
Dead-reckoning-based indoor localization with wi-fi infrastructure support
, 2014 In this project, a Wi-Fi Correction Scheme is proposed so the SparseTrack System is modified. The modified SparseTrack System consists of two sub-systems: the Dead-Reckoning Sub-System and the Ranging Sub-System.
Guo, Jie
core
Indoor navigation incorporating multiple localisation sources and pedestrian dead reckoning
, 2021 Navigation systems have become an integral part of our daily lives. The Global Positioning System (GPS) is widely used to determine outdoor positions and is capable of achieving high accuracy and reliability due to extensive research over the years ...
Lim, Bo Zhi
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Inertial navigation with dead reckoning
, 2013 Positioning is gaining importance not only in military activities, but also in people’s daily life. However, GPS is not always available. The satellite signals could get blocked or degraded by buildings, trees, and canyons.
Wang, Yue.
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Dead reckoning algorithm for multiplayer online games
, 2016 Multiplayer online games involve a lot of information passing between each player to render correct players’ movements and positions. In every movement a player makes, he broadcasts his movement information to other players so that other players see him ...
Jaya, Iryanto
core