Results 51 to 60 of about 11,008,598 (301)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Deadbeat direct power control for dual three‐phase PMSG used in wind turbines

IET Renewable Power Generation, 2021
The classical switching‐table‐based direct power control usually employs one active voltage vector during the whole sample period, which will bring distinct current harmonics and large power ripple.
Shibo Jin, Wenxiang Zhao, Jinghua Ji, Dezhi Xu   +3 more
doaj   +1 more source

Data-driven deadbeat control with application to output regulation

, 2017
In this paper, a data-driven design of deadbeat controllers is proposed, which is later generalized in different ways to allow for trade-offs between convergence rate and control effort.
Galeani, Sergio, Sassano, Mario, Galeani, S, de Carolis, G, de Carolis, Giovanni, Giovanni de Carolis, Sergio Galeani, Sassano, M, Mario Sassano   +8 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

An improved two-beat deadbeat synchronous predictive current control strategy for MMC based on Newton interpolation method

Frontiers in Energy Research
Modular Multilevel Converter (MMC) is widely used in applications such as High Voltage Direct Current (HVDC) transmission, AC/DC power conversion centers, and large-scale power quality management in electrical grids due to its highly modular structure ...
Yuan Cheng, Yuan Cheng, Yuan Cheng, Hui Zhang, Jing Xing, Zihan Xiao   +5 more
doaj   +1 more source

Fractional-Order Time Delay Compensation in Deadbeat Control for Power Converters [PDF]

, 2018
Deadbeat control scheme is widely implemented in the control of power electronics and electrical drives, which is of simplification, rapidity and flexibility.
Shihua Li, Keliang Zhou, Zhou, Keliang, Li, Shihua, Zuo Wang, Yang, Yongheng; id_orcid, Yongheng Yang, Wang, Zuo, Yang, Yongheng   +8 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Dual closed-loop vector PI control and deadbeat current control of permanent magnet synchronous motor

Sukkur IBA Journal of Emerging Technologies
Permanent magnet synchronous motors (PMSMs) offer advantages such as high torque, power density, and energy efficiency, making them essential in power electronics, aerospace, and daily life.
Syed Abid Ali Shah Bukhari, Vikram Kumar, Muhammad Ahsan Niazi, Qazi Sajid   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source