Results 91 to 100 of about 365,870 (389)

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

Cell Reports, 2015
Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET) in inner ear sensory hair cells. Transmembrane channel-like 1 and 2 (TMC1 and TMC2) are essential for MET and are hypothesized to be components of the MET ...
Kiyoto Kurima, Seham Ebrahim, Bifeng Pan, Miloslav Sedlacek, Prabuddha Sengupta, Bryan A. Millis, Runjia Cui, Hiroshi Nakanishi, Taro Fujikawa, Yoshiyuki Kawashima, Byung Yoon Choi, Kelly Monahan, Jeffrey R. Holt, Andrew J. Griffith, Bechara Kachar   +14 more
doaj   +1 more source

Targeted Exon Sequencing Successfully Discovers Rare Causative Genes and Clarifies the Molecular Epidemiology of Japanese Deafness Patients

PLoS ONE, 2013
Target exon resequencing using Massively Parallel DNA Sequencing (MPS) is a new powerful strategy to discover causative genes in rare Mendelian disorders such as deafness.
Maiko Miyagawa, Takehiko Naito, S. Nishio, N. Kamatani, S. Usami   +4 more
semanticscholar   +1 more source

Automated Creak Identifies Laryngeal Dystonia During Conversational Speech

The Laryngoscope, EarlyView.
This study evaluated whether automated creak distinguished speakers with adductor laryngeal dystonia (AdLD), muscle tension dysphonia (MTD), and those without voice disorders during conversational speech. Automated creak estimates were able to differentiate speakers with AdLD from MTD and controls with similar performance across different types of ...
Daria A. Dragicevic, Cara E. Sauder, Daniel P. Buckley, Laura E. Toles, Lauren F. Tracy, J. Pieter Noordzij, Gregory A. Grillone, Ted Mau, John Paul Giliberto, Tanya K. Meyer, Albert L. Merati, Tanya L. Eadie, Cara E. Stepp, Katherine L. Marks   +13 more
wiley   +1 more source

Investigating the Availability and Accessibility of Mental Health Services for Deaf Texans [PDF]

, 2016
This study explored the availability and accessibility of mental health services for Deaf Texans from the perspective of practicing clinicians. Although the Americans with Disabilities Act mandates that Deaf people have the right to equal access for all ...
Peschke, Naomi
core   +1 more source

The acoustic change complex as a diagnostic tool for cochlear dead regions evaluated in normally hearing adults

Scientific Reports
The loss of inner hair cells and/or neurons in the cochlea leads to cochlear dead regions (DRs). One of the consequences of DRs is noisy transmission of information from the cochlea to the brain, which results in poorer than expected perception of speech
Anna Schelenz, Emanuele Perugia, Lin Wu, Ewa Skrodzka, Karolina Kluk   +4 more
doaj   +1 more source

CK2 Phosphorylates and Inhibits TAp73 Tumor Suppressor Function to Promote Expression of Cancer Stem Cell Genes and Phenotype in Head and Neck Cancer

Neoplasia: An International Journal for Oncology Research, 2014
Cancer stem cells (CSC) and genes have been linked to cancer development and therapeutic resistance, but the signaling mechanisms regulating CSC genes and phenotype are incompletely understood. CK2 has emerged as a key signal serine/threonine kinase that
Hai Lu, Carol Yan, Xin Xin Quan, Xinping Yang, Jialing Zhang, Yansong Bian, Zhong Chen, Carter Van Waes   +7 more
doaj   +1 more source

Mandibular hypoplasia-deafness-progeroid features-lipodystrophy syndrome [PDF]

, 2020
INSERM
openalex   +1 more source

Robotic‐Assisted Electrode Array Insertion Improves Stability of Acoustic Hearing Thresholds

The Laryngoscope, EarlyView.
This study evaluated the impact of robotic‐assisted electrode array insertion on rates of delayed‐onset hearing loss (DOHL). DOHL occurred in 22 of 60 subjects (37%) in the manual cohort compared with 2 of 29 subjects (7%) in the robotic‐assisted cohort, representing a statistically significant reduction (p = 0.002).
Uzair A. Khan, Rachel A. Scheperle, Grant Podhajsky, Meggan J. Lind, Camille C. Dunn, Alexander D. Claussen, Bruce J. Gantz, Marlan R. Hansen   +7 more
wiley   +1 more source

Clinical efficacy of mepolizumab and dupilumab for eosinophilic otitis media: Analysis of patient clinical characteristic

Allergology International
Background: Eosinophilic otitis media (EOM) is characterized by eosinophilic infiltration of the middle ear; it is frequently associated with bronchial asthma and chronic rhinosinusitis with nasal polyposis. Although biologics have been used to treat EOM,
Saori Kikuchi, Tomonori Sugiyama, Saemi Suzuki, Yukiko Iino   +3 more
doaj   +1 more source

Heritability and complex segregation analysis of deafness in Jack Russell Terriers

BMC Veterinary Research, 2007
Background The association between patterns of pigmentation and deafness in the dog has a long-documented history, with reports dating back over one hundred years.
Strain George M, Cargill Edward J, Famula Thomas R   +2 more
doaj   +1 more source