Results 31 to 40 of about 365,870 (389)
Audiology and Neurotology, 2015 For adult patients with single-sided deafness (SSD), treatment with a cochlear implant (CI) is well established as an acceptable and beneficial hearing rehabilitation method administered routinely in clinical practice. In contrast, for children with SSD,
S. Arndt +5 more
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Seeing the Deaf in "Deafness" [PDF]
Journal of Deaf Studies and Deaf Education, 2008 This article draws on some of the existing literature on the politics of identity and representation as related to minority group formation. It applies this to constructions of Deaf2 identity from a cultural and linguistic perspective and contrasts this with dominant constructions of Deaf people as disabled. It highlights a number of ways in which Deaf
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OncoImmunology, 2018 Loss or mutation of TP53 has been linked to alterations in anti-tumor immunity as well as dysregulation of cell cycle and apoptosis. We explored immunologic effects and mechanisms following restoration of wild-type human TP53 cDNA in murine oral cancer ...
Ellen C. Moore +8 more
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OncoImmunology, 2018 Preclinical evidence suggests that high-dose hypofractionated ionizing radiation (IR) can enhance anti-tumor immunity and result in significant tumor control when combined with immune checkpoint blockade (ICB).
Megan Morisada +9 more
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AAV‐Mediated Gene Therapy Restores Hearing in Patients with DFNB9 Deafness
Advancement of scienceMutations in OTOFERLIN (OTOF) lead to the autosomal recessive deafness 9 (DFNB9). The efficacy of adeno‐associated virus (AAV)‐mediated OTOF gene replacement therapy is extensively validated in Otof‐deficient mice.
J. Qi +24 more
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Ear & Hearing, 2000 The last decade has led to the identification of several mitochondrial DNA mutations associated with hearing loss. Since the only known function of the human mitochondrial chromosome is to participate in the production of chemical energy through oxidative phosphorylation, it was not unexpected that mitochondrial mutations interfering with energy ...
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A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function [PDF]
, 2019 Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations
Buratto, Damiano +12 more
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Frontiers in Cellular Neuroscience, 2015 Hearing loss due to mutations in the connexin gene family, which encodes gap junctional proteins, is a common form of hereditary deafness. In particular, connexin 26 (Cx26, GJB2) mutations are responsible for ~50% of non-syndromic hearing loss, which is ...
Jeffrey C. Wingard, Hong-Bo Zhao
semanticscholar +1 more source
Deafness: Disability or Culture? Best Practices Regarding Controversial Interventions for Deaf and Hard of Hearing Students [PDF]
, 2020 Background: Many people in the deaf community view deafness as a distinct culture, with its own unique language and history. They reject the use of assistive technologies which can restore hearing for themselves and their children.
Ziemba, Jacob
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Shedding light on optical cochlear implant progress
EMBO Molecular Medicine, 2020 Electrical cochlear implants (CI) currently lack the frequency and intensity resolution to allow detection of complex sounds in background noise. The use of microscale optoelectronics in conjunction with optogenetics provides a promising direction in CI ...
Siân R Kitcher, Catherine JC Weisz
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