Results 21 to 30 of about 127,275 (301)

Does probe-tube verification of real-ear hearing aid amplification characteristics improve outcomes in adult hearing aid users? A protocol for a systematic review

open access: yesBMJ Open, 2020
Introduction Using a probe-tube microphone to measure and adjust the real-ear performance of the hearing aid to match the prescription target is recommended and widely used in clinical practice.
Kevin J Munro   +2 more
doaj   +1 more source

Is the outcome of fitting hearing aids to adults affected by whether an audiogram-based prescription formula is individually applied? A systematic review protocol

open access: yesBMJ Open, 2021
Introduction Hearing aids are typically programmed using the individual’s audiometric thresholds. Developments in technology have resulted in a new category of direct-to-consumer devices, which are not programmed using the individual’s audiometric ...
Kevin J Munro   +2 more
doaj   +1 more source

Refining surgical techniques for efficient posterior semicircular canal gene delivery in the adult mammalian inner ear with minimal hearing loss

open access: yesScientific Reports, 2021
Hearing loss is a common disability affecting the world’s population today. While several studies have shown that inner ear gene therapy can be successfully applied to mouse models of hereditary hearing loss to improve hearing, most of these studies rely
Jianliang Zhu   +6 more
doaj   +1 more source

Single-Cell RNA-Seq of Cisplatin-Treated Adult Stria Vascularis Identifies Cell Type-Specific Regulatory Networks and Novel Therapeutic Gene Targets

open access: yesFrontiers in Molecular Neuroscience, 2021
The endocochlear potential (EP) generated by the stria vascularis (SV) is necessary for hair cell mechanotransduction in the mammalian cochlea. We sought to create a model of EP dysfunction for the purposes of transcriptional analysis and treatment ...
Ian A. Taukulis   +8 more
doaj   +1 more source

What Caused Beethoven's Deafness? [PDF]

open access: yes, 2019
https://deepblue.lib.umich.edu/bitstream/2027.42/154596/1/PBS - What Caused Beethovens Deafness - 17Dec2019 ...
Markel, Howard
core   +4 more sources

Nanocomplex-based TP53 gene therapy promotes anti-tumor immunity through TP53- and STING-dependent mechanisms

open access: yesOncoImmunology, 2018
Loss or mutation of TP53 has been linked to alterations in anti-tumor immunity as well as dysregulation of cell cycle and apoptosis. We explored immunologic effects and mechanisms following restoration of wild-type human TP53 cDNA in murine oral cancer ...
Ellen C. Moore   +8 more
doaj   +1 more source

Cerebral lateralisation of first and second languages in bilinguals assessed using functional transcranial Doppler ultrasound [version 2; peer review: 2 approved, 1 not approved]

open access: yesWellcome Open Research, 2021
Background: Lateralised language processing is a well-established finding in monolinguals. In bilinguals, studies using fMRI have typically found substantial regional overlap between the two languages, though results may be influenced by factors such as ...
Dorothy V. M. Bishop   +8 more
doaj   +1 more source

Progress in the treatment of sudden deafness [PDF]

open access: yes, 2017
<p>In recent years, the incidence of sudden deafness has a tendency to rise. Most scholars believe that the cause of the disease are virus infection, lymph fluid and cochlear circulation dysfunction and so on.
Fang Yuan, Jian Wang
core   +2 more sources

No Effect of Interstimulus Interval on Acoustic Reflex Thresholds

open access: yesTrends in Hearing, 2019
The acoustic reflex (AR), a longstanding component of the audiological test battery, has received renewed attention in the context of noise-induced cochlear synaptopathy—the destruction of synapses between inner hair cells and auditory nerve fibers ...
Hannah Guest   +7 more
doaj   +1 more source

PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation

open access: yesOncoImmunology, 2018
Preclinical evidence suggests that high-dose hypofractionated ionizing radiation (IR) can enhance anti-tumor immunity and result in significant tumor control when combined with immune checkpoint blockade (ICB).
Megan Morisada   +9 more
doaj   +1 more source

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