Results 21 to 30 of about 94,072 (265)

PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation

OncoImmunology, 2018
Preclinical evidence suggests that high-dose hypofractionated ionizing radiation (IR) can enhance anti-tumor immunity and result in significant tumor control when combined with immune checkpoint blockade (ICB).
Megan Morisada, Paul E. Clavijo, Ellen Moore, Lillian Sun, Michael Chamberlin, Carter Van Waes, James W. Hodge, James B. Mitchell, Jay Friedman, Clint T. Allen   +9 more
doaj   +1 more source

Cerebral lateralisation of first and second languages in bilinguals assessed using functional transcranial Doppler ultrasound [version 2; peer review: 2 approved, 1 not approved]

Wellcome Open Research, 2021
Background: Lateralised language processing is a well-established finding in monolinguals. In bilinguals, studies using fMRI have typically found substantial regional overlap between the two languages, though results may be influenced by factors such as ...
Dorothy V. M. Bishop, Clara R. Grabitz, Sophie C. Harte, Kate E. Watkins, Miho Sasaki, Eva Gutierrez-Sigut, Mairéad MacSweeney, Zoe V. J. Woodhead, Heather Payne   +8 more
doaj   +1 more source

No Effect of Interstimulus Interval on Acoustic Reflex Thresholds

Trends in Hearing, 2019
The acoustic reflex (AR), a longstanding component of the audiological test battery, has received renewed attention in the context of noise-induced cochlear synaptopathy—the destruction of synapses between inner hair cells and auditory nerve fibers ...
Hannah Guest, Kevin J. Munro, Samuel Couth, Rebecca E. Millman, Garreth Prendergast, Karolina Kluk, Carlyn Murray, Chris Plack   +7 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Altered ABR Waveform Patterns in Tinnitus Patients With Normal Full-Frequency Hearing May Be Induced by Abnormal Middle Ear Muscle Activity Via the Trigeminal Nerve System

Journal of Otolaryngology - Head and Neck Surgery
Importance Evidence regarding the mechanism of tinnitus in patients with normal full-frequency hearing remains limited. This study investigated the auditory brainstem response (ABR) waveform patterns in these patients to address this unmet need, which is
Yun Jiang BM, Tianyi Ni MM, Hongbo Xie MM, Siyi Yang BM, Ziyuan Lin BM, Jian Ruan BM, Min Zhang PhD, Xiuling Lu BSN, Wenjing Zhang BS, Wenjing Su BS, Yuehong Liu PhD, Zhao Han PhD   +11 more
doaj   +1 more source

Shedding light on optical cochlear implant progress

EMBO Molecular Medicine, 2020
Electrical cochlear implants (CI) currently lack the frequency and intensity resolution to allow detection of complex sounds in background noise. The use of microscale optoelectronics in conjunction with optogenetics provides a promising direction in CI ...
Siân R Kitcher, Catherine JC Weisz
doaj   +1 more source

Determining if T cell antigens are naturally processed and presented on HLA class I molecules

BMC Immunology, 2022
Background Determining T cell responses to naturally processed and presented antigens is a critical immune correlate to determine efficacy of an investigational immunotherapeutic in clinical trials.
Jay Friedman, Sreenivasulu Gunti, Maxwell Lee, Ke Bai, Christian Hinrichs, Clint T. Allen   +5 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Multifunctional redox modulator prevents blast-induced loss of cochlear and vestibular hair cells and auditory spiral ganglion neurons

Scientific Reports
Blast wave exposure, a leading cause of hearing loss and balance dysfunction among military personnel, arises primarily from direct mechanical damage to the mechanosensory hair cells and supporting structures or indirectly through excessive oxidative ...
Dalian Ding, Senthilvelan Manohar, Peter F. Kador, Richard Salvi   +3 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source